Topical cyproterone acetate treatment in women with acne: A placebo- controlled trial

Archives of Dermatology

Volumn 134, Issue 4, 1998, Pages 459-463

  Gruber, Doris M ^a,b   Sator, Michael O ^a   Joura, Elmar A ^a   Kokoschka, Eva Maria ^a   Heinze, Georg ^a   Huber, Johannes C ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; CYPROTERONE ACETATE; PLACEBO;

ACNE; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; HORMONAL THERAPY; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN DISEASE; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ACNE VULGARIS; ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADULT; ANDROGEN ANTAGONISTS; CYPROTERONE ACETATE; DRUG COMBINATIONS; ETHINYL ESTRADIOL; FEMALE; HUMANS; TREATMENT OUTCOME;

EID: 0031969710     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.134.4.459     Document Type: Article

References (12)

1. Cunliffe WJ, Shuster S, Cassels Smith AJ. The effect of topical cyproterone acetate on sebum secretion in patients with acne. Br J Dermatol. 1969;81:200-201.
2. Pye RJ, Burton JL, Harris JI. Effect of 1% cyproterone acetate in cetomacrogol cream BPC (formula A) on sebum excretion rate in patients with acne. Br J Dermatol. 1976;95:427-428.
3. Sciarra F, Toscano V, Concolino G, Di Silverio F. Androgens: clinical applications. J Steroid Biochem Mol Biol. 1990;37:349-362.
4. Burke BM, Cunliffe WJ. The assessment of acne vulgaris: the Leeds technique. Br J Dermatol. 1984;111:83-87.
5. Fiet J, Morville R, Chemama D, et al. Percutaneous absorption of 5 alpha dihydrotestosterone in man, I: plasma androgen and gonadotropin levels in normal adult men after percutaneous administration of 5 alpha dinydrotestosterone. Int J Androl. 1982;5:586-594.
6. Scott RT, Ross B, Anderson S, et al. Pharmacokinetics of percutaneous estradiol: a crossover study using a gel and a transdermal system in comparison with oral micronized estradiol. Obstet Gynecot. 1991;77:758-764.
7. Muhlemann MF, Carter GD, Cream JJ, et al. Oral spironolactone: an effective treatment of acne vulgaris in women. Br J Dermatol. 1986;115:227-232.
8. Adashi EY. Potential utility of gonadotropin-releasing hormone agonist in the management of ovarian hyperandrogenism. Fertil Steril. 1990;53:765-779.
9. Cusan I, Dupont A, Gomez LL, Tremblay RR, Labrie F. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. fertil Steril. 1994;61:281-287.
10. Strauss JS, Pochi PE. The effect of cyclic progestogen-estrogen therapy on sebum and acne in women. JAMA. 1964;190:815-819.
11. Simpson NB, Bowden PE, Forster RA, et al. The effect of topically applied progesterone on sebum excretion rate. Br J Dermatol. 1979;100:687-692.
12. Dorfmann RI. Biological activity of antiandrogens. Br J Dermatol. 1970;82 (suppl 6):3-8.