Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin α7 induced cell growth suppression

Cancer Research

Volumn 70, Issue 11, 2010, Pages 4375-4384

  Han, Yu Chen ^a   Yu, Yan P ^a   Nelson, Joel ^a   Wu, Chuanyue ^a   Wang, Hui ^a   Michalopoulos, George K ^a   Luo, Jian Hua ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA7 INTEGRIN; INTEGRIN LINKED KINASE; MINICHROMOSOME MAINTENANCE PROTEIN 7;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER INHIBITION; CELL GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANTIGENS, CD; CELL CYCLE PROTEINS; CELL GROWTH PROCESSES; CELL LINE; CELL NUCLEUS; DNA, NEOPLASM; DNA-BINDING PROTEINS; HUMANS; INTEGRIN ALPHA CHAINS; MALE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES;

EID: 77953157145     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-4403     Document Type: Article

References (22)

1. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-687
2. Ren B, Yu YP, Tseng GC, et al. Analysis of integrin α7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma. J Natl Cancer Inst 2007;99:868-880
3. Blow JJ, Hodgson B. Replication licensing-defining the proliferative state? Trends Cell Biol 2002;12:72-78
4. Ren B, Yu G, Tseng GC, et al. MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene 2006;25:1090-1098
5. Levesque MH, El-Alfy M, Berger L, Labrie F, Labrie C. Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases. Urology 2007;69:196-201.
6. Honeycutt KA, Chen Z, Koster MI, et al. Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. Oncogene 2006;25:4027-4032
7. Shi YK, Yu YP, Zhu ZH, et al. MCM7 interacts with androgen receptor. Am J Pathol 2008;173:1758-1767
8. Liu BC, Li MX, Zhang JD, et al. Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Am J Nephrol 2008;28:143-151
9. Yu YP, Luo JH. Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res 2006;66:7414-7419
10. Jing L, Liu L, Yu YP, et al. Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol 2004;164:1799-1806 (Pubitemid 38529782)
11. Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta 2004;1692:55-62.
12. Legate KR, Montanez E, Kudlacek O, Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 2006;7:20-31.
13. Guo L, Sanders PW, Woods A, Wu C. The distribution and regulation of integrin-linked kinase in normal and diabetic kidneys. Am J Pathol 2001;159:1735-1742 (Pubitemid 33062516)
14. Guo L, Wu C. Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex. FASEB J 2002;16:1298-1300
15. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, et al. Regulation of cell adhesion and anchorage-dependent growth by a new β 1-integrin-linked protein kinase. Nature 1996;379:91-96
16. Acconcia F, Barnes CJ, Singh RR, Talukder AH, Kumar R. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A 2007;104:6782-6787
17. Donthamsetty S, Bowen W, Mars W, et al. Liver specific ablation of integrin linked kinase (ILK) in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration. Toxicol Sci 2009;113:358-366
18. Apte U, Gkretsi V, Bowen WC, et al. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 2009;50:844-851
19. Gkretsi V, Apte U, Mars WM, et al. Liver-specific ablation of integrinlinked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 2008;48:1932-1941
20. Kan T, Sato F, Ito T, et al. The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. Gastroenterology 2009;136:1689-1700
21. Koppen A, Ait-Aissa R, Koster J, et al. Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma. Eur J Cancer 2007;43:2413-2422
22. Ambs S, Prueitt RL, Yi M, et al. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 2008;68:6162-6170