Analysis of integrin α7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma

Journal of the National Cancer Institute

Volumn 99, Issue 11, 2007, Pages 868-880

  Ren, Baoguo ^a   Yu, Yan P ^a   Tseng, George C ^b   Wu, Chuanyue ^a   Chen, Ka ^a   Rao, Uma N ^a   Nelson, Joel ^a   Michalopoulos, George K ^a   Luo, Jian Hua ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; ALPHA7 INTEGRIN; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR; GENOMIC DNA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MESSENGER RNA; ALPHA INTEGRIN; LEUKOCYTE ANTIGEN; SMALL INTERFERING RNA; TUMOR MARKER;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER RECURRENCE; CANCER SURVIVAL; CELL ASSAY; CELL MIGRATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA SEQUENCE; FEMALE; GENE MUTATION; GENETIC CODE; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LEIOMYOSARCOMA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; MICROARRAY ANALYSIS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SCID MOUSE; SURVIVAL RATE; SURVIVAL TIME; XENOGRAFT; ANIMAL; CELL CULTURE; CELL MOTION; CLONOGENIC ASSAY; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; GENETICS; IMMUNOPRECIPITATION; LIVER TUMOR; METABOLISM; METASTASIS; MIDDLE AGED; MOUSE MUTANT; MUTATION; PATHOLOGY; PROSTATE TUMOR; TISSUE MICROARRAY; TUMOR RECURRENCE;

AGED; ANIMALS; ANTIGENS, CD; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; COLONY-FORMING UNITS ASSAY; GLIOBLASTOMA; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INTEGRIN ALPHA CHAINS; LEIOMYOSARCOMA; LIVER NEOPLASMS; MALE; MICE; MICE, SCID; MICROARRAY ANALYSIS; MIDDLE AGED; MUTATION; NEOPLASM RECURRENCE, LOCAL; PROSTATIC NEOPLASMS; RNA, SMALL INTERFERING; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 34347385686     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djk199     Document Type: Article

References (26)

1. Hynes RO. Integrins: Bidirectional, allosteric signaling machines. Cell 2002;110:673-87.
2. Pulkkinen L, Uitto J. Mutation analysis and molecular genetics of epidermolysis bullosa. Matrix Biol 1999;18:29-42.
3. Fassler R, Meyer M. Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 1995;9:1896-908.
4. Georges-Labouesse E, Mark M, Messaddeq N, Gansmuller A. Essential role of alpha 6 integrins in cortical and retinal lamination. Curr Biol 1998;8:983-6.
5. Kreidberg JA, Donovan MJ, Goldstein SL, Rennke H, Shepherd K, Jones RC, et al. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 1996;122:3537-47.
6. McHugh KP, Hodivala-Dilke Y, Zheng MH, Namba N, Lam J, Novack D, et al. Mice laking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 2000;105:433-40.
7. Taverna D, Disatnik MH, Rayburn H, Bronson RT, Yang J, Rando TA, et al. Dystrophic muscle in mice chimeric for expression of alpha5 integrin. J Cell Biol 1998;143:849-59.
8. Brakebusch C, Grose R, Quondamatteo F, Ramirez A, Jorcano JL, Pirro A, et al. Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes. Embo J 2000;19:3990-4003.
9. Werner A, Willem M, Jones LL, Kreutzberg GW, Mayer U, Raivich G. Impaired axonal regeneration in alpha7 integrin-deficient mice. J Neurosci 2000;20:1822-30.
10. Mayer U, Saber G, Fassler R, Bornemann A, Echtermeyer F, von der Mark H, et al. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat Genet 1997;17:318-23.
11. Basani RB, French DL, Vilaire G, Brown DL, Chen F, Coller BS, et al. A naturally occurring mutation near the amino terminus of alphaIIb defines a new region involved in ligand binding to alphaIIbbeta3. Blood 2000;95:180-8.
12. Hayashi YK, Chou FL, Engvall E, Ogawa M, Matsuda C, Hirabayashi S, et al. Mutations in the integrin alpha7 gene cause congenital myopathy. Nat Genet 1998;19:94-7.
13. Flintoff-Dye NL, Welser J, Rooney J, Scowen P, Tamowski S, Hatton W, et al. Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn 2005;234:11-21.
14. Echtermeyer F, Schober S, Poschl E, von der Mark H, von der Mark K. Specific induction of cell motility on laminin by alpha 7 integrin. J Biol Chem 1996;271:2071-5.
15. LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, et al. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 2002;62:4499-506.
16. Luo JH, Yu YP, Cieply K, Lin F, Deflavia P, Dhir R, et al. Gene expression analysis of prostate cancers. Mol Carcinog 2002;33:25-35.
17. Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004;22:2790-9.
18. Rice J. Mathematical statistics and data analysis. Pacific Grove (CA): Duxbury Press; 2006.
19. Ren B, Yu G, Tseng GC, Cieply K, Gavel T, Nelson J, et al. MCM7 amplification and overexpression are associated with prostate cancer progression. Oncogene 2006;25:1090-8.
20. Jing L, Liu L, Yu YP, Dhir R, Acquafondada M, Landsittel D, et al. Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol 2004;164:1799-806.
21. Yu YP, Luo JH. Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res 2006;66:7414-9.
22. Hosmer DW, Lemeshow S. Applied survival analysis. Hoboken (NJ): Wiley; 2003.
23. Ren B, Yu YP, Jing L, Liu L, Michalopoulos GK, Luo JH, et al. Gene expression analysis of human soft tissue leiomyosarcomas. Hum Pathol 2003;34:549-58.
24. Gyuris J, Golemis E, Chertkov H, Brent R. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 1993;75: 791-803.
25. Hannon GJ, Casso D, Beach DKAP. a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc Natl Acad Sci U S A 1994; 91:1731-5.
26. Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, et al. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood 2000;96:2116-24.