Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4255-4268

  Du, Yongli ^a   Li, Qunyi ^b   Xiong, Bing ^a   Hui, Xin ^b   Wang, Xin ^a   Feng, Yang ^b   Meng, Tao ^a   Hu, Dingyu ^a   Zhang, Datong ^c   Wang, Mingwei ^a,b   Shen, Jingkang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b National Center for Drug Screening   (China)

^c QILU UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Aromatic amino ketone; Mannich reaction; Non steroidal progesterone receptor antagonist; Progesterone receptor (PR); Progesterone receptor antagonist

Indexed keywords

3 (3 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 P TOLYLPROPAN 1 ONE; 3 (4 FLUOROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 P TOLYLPROPAN 1 ONE; 3 (4 METHOXYPHENYLAMINO) 3 PHENYL 1 P TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (3 BROMOPHENYL) 3 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (3 CHLOROPHENYL) 3 (4 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (3 CHLOROPHENYL) 3 (4 TRIFLUOROMETHYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (3 CYANOPHENYL) 3 [4 (TRIFLUOROMETHYL)PHENYL]PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (3 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (4 BROMOPHENYL) 3 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (4 CHLOROPHENYL) 3 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (4 CYANOPHENYL) 3 (THIOPHEN 3 YL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (4 CYCLOHEXYLPHENYL) 3 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1 (4 PHENYL PHENYL) 3 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 1,3 BIS(3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 (4 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 (4 MORPHOLINOPHENY)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 M TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 P TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3 FLUOROPHENYL) 1 PHENYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3,4,5 TRIMETHOXYPHENYL) 1 M TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (3,4,5 TRIMETHOXYPHENYL) 1 P TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (4 [TRIFLUOROMETHYL]PHENYL) 1 (3 FLUOROPHENYL)PROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 (THIOPHEN 3 YL) 1 P TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 [4 (TRIFLUOROMETHYL)PHENYL] 1 M TOLYLPROPAN 1 ONE; 3 (4 NITROPHENYLAMINO) 3 PHENYL 1 P TOLYLPROPAN 1 ONE; 3 [4 (TRIFLUOROMETHYL)PHENYLAMINO] 3 (3 FLUOROPHENYL) 1 P TOLYLPROPAN 1 ONE; ANTIGESTAGEN; KETONE DERIVATIVE; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; 3-(4-NITROPHENYLAMINO)-3-(3-FLUOROPHENYL)-1-P-TOLYLPROPAN-1-ONE; ANILINE DERIVATIVE; CHALCONE DERIVATIVE; KETONE; LIGAND; PROTEIN BINDING;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DECIDUALIZATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; GENETIC TRANSFECTION; MALE; MOUSE; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; HUMAN; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANILINE COMPOUNDS; ANIMALS; BINDING SITES; CHALCONES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; KETONES; LIGANDS; MICE; MOLECULAR CONFORMATION; PROTEIN BINDING; RECEPTORS, PROGESTERONE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 77953133502     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.092     Document Type: Article

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