Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether

Journal of Medicinal Chemistry

Volumn 39, Issue 9, 1996, Pages 1778-1789

  Hamann, Lawrence G ^a   Farmer, Luc J ^a   Johnson, Michael G ^a   Bender, Steven L ^a,b   Mais, Dale E ^a   Wang, Ming Wei ^a   Crombie, Diane ^a   Goldman, Mark E ^a,c   Jones, Todd K ^a  

^a LIGAND PHARMACEUTICALS INC   (United States)

^b AGOURON PHARMACEUTICALS INC   (United States)

^c CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; CYCLOCYMOPOL METHYL ETHER DERIVATIVE; GLUCOCORTICOID RECEPTOR; MIFEPRISTONE; ONAPRISTONE; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ALGA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DECIDUALIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANISOLES; CELL LINE; CYCLOHEXANES; CYCLOHEXENES; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029916422     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950747d     Document Type: Article

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