Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 14, 2006, Pages 3777-3779

  Wiethe, Robert W ^a   Stewart, Eugene L ^a   Drewry, David H ^a   Gray, David W ^a   Mehbob, Abdul ^a   Hoekstra, William J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Diazepine; Progesterone receptor

Indexed keywords

5 BROMO 2 THIOPHENESULFONAMIDE; ANTIGESTAGEN; DIAZEPINE DERIVATIVE; MIFEPRISTONE; PROGESTERONE RECEPTOR; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING;

AZEPINES; AZIRINES; BINDING SITES; CELLS, CULTURED; DIHYDROPYRIDINES; HUMANS; LIGANDS; MODELS, CHEMICAL; RECEPTORS, PROGESTERONE;

EID: 33746718797     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.055     Document Type: Article

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10. ® scavenger resin (135 mg) was added to each well and the plate resealed and agitated for 2 h. The reaction well contents were filtered into a 96-well Multichem plate and washed with DCM (3× 0.5 mL). The filtrate was concentrated in vacuo to afford 3a as a solid (30 mg, 64% yield, 85% purity by LC/MS).
11. i.
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