Distribution of hypothalamic neurons with orexin (hypocretin) or melanin concentrating hormone (MCH) immunoreactivity and multisynaptic connections with diaphragm motoneurons

Brain Research

Volumn 1323, Issue , 2010, Pages 119-126

  Badami, Varun M ^a   Rice, Cory D ^a   Lois, James H ^a   Madrecha, Jayesh ^a   Yates, Bill J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Homeostasis; Rabies virus; Respiration; Transneuronal tracing

Indexed keywords

MELANIN CONCENTRATING HORMONE; OREXIN A; OREXIN B;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREATHING; CAT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIAPHRAGM; HYPOTHALAMUS; IMMUNOREACTIVITY; MOTONEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RABIES; RABIES VIRUS; RESPIRATION CONTROL; SYNAPSE;

ANIMALS; CATS; DIAPHRAGM; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANINS; MOTOR NEURONS; NEURAL PATHWAYS; NEURONAL TRACT-TRACERS; NEUROPEPTIDES; PITUITARY HORMONES; RESPIRATION;

ANIMALIA; RABIES VIRUS;

EID: 77953132137     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.02.002     Document Type: Article

References (51)

1. Abrahamson E.E., and Moore R.Y. The posterior hypothalamic area: chemoarchitecture and afferent connections. Brain Res. 889 (2001) 1-22
2. Aston-Jones G., and Card J.P. Use of pseudorabies virus to delineate multisynaptic circuits in brain: opportunities and limitations. J. Neurosci. Methods 103 (2000) 51-61
3. Aston-Jones G., Smith R.J., Moorman D.E., and Richardson K.A. Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 56 Suppl 1 (2009) 112-121
4. Bayer L., Mairet-Coello G., Risold P.Y., and Griffond B. Orexin/hypocretin neurons: chemical phenotype and possible interactions with melanin-concentrating hormone neurons. Regul. Pept. 104 (2002) 33-39
5. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., Vale W., and Sawchenko P.E. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 319 (1992) 218-245
6. Bourgin P., Huitron-Resendiz S., Spier A.D., Fabre V., Morte B., Criado J.R., Sutcliffe J.G., Henriksen S.J., and de Lecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 20 (2000) 7760-7765
7. Broberger C., De Lecea L., Sutcliffe J.G., and Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 402 (1998) 460-474
8. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
9. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett II F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., and Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95 (1998) 322-327
10. de Lecea L., Sutcliffe J.G., and Fabre V. Hypocretins/orexins as integrators of physiological information: lessons from mutant animals. Neuropeptides 36 (2002) 85-95
11. Deng B.S., Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. J. Appl. Physiol. 103 (2007) 1772-1779
12. Dias M.B., Li A., and Nattie E.E. Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness. J. Physiol. 587 (2009) 2059-2067
13. Fortuna M.G., Stornetta R.L., West G.H., and Guyenet P.G. Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation. J. Physiol. 587 (2009) 5121-5138
14. Georgescu D., Sears R.M., Hommel J.D., Barrot M., Bolanos C.A., Marsh D.J., Bednarek M.A., Bibb J.A., Maratos-Flier E., Nestler E.J., and DiLeone R.J. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J. Neurosci. 25 (2005) 2933-2940
15. Gerashchenko D., Kohls M.D., Greco M., Waleh N.S., Salin-Pascual R., Kilduff T.S., Lappi D.A., and Shiromani P.J. Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J. Neurosci. 21 (2001) 7273-7283
16. Goutagny R., Luppi P.H., Salvert D., Gervasoni D., and Fort P. GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle. NeuroReport 16 (2005) 1069-1073
17. Guan J.L., Uehara K., Lu S., Wang Q.P., Funahashi H., Sakurai T., Yanagizawa M., and Shioda S. Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 1523-1532
18. Horn E.M., and Waldrop T.G. Suprapontine control of respiration. Resp. Physiol. 114 (1998) 201-211
19. Kelly R.M., and Strick P.L. Rabies as a transneuronal tracer of circuits in the central nervous system. J. Neurosci. Methods 103 (2000) 63-71
20. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
21. Lois J.H., Rice C.D., and Yates B.J. Neural circuits controlling diaphragm function in the cat revealed by transneuronal tracing. J. Appl. Physiol. 106 (2009) 138-152
22. Martynska L., Wolinska-Witort E., Chmielowska M., Bik W., and Baranowska B. The physiological role of orexins. Neuro Endocrinol. Lett. 26 (2005) 289-292
23. Modirrousta M., Mainville L., and Jones B.E. Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur. J. Neurosci. 21 (2005) 2807-2816
24. Nadin-Davis S.A., Sheen M., Abdel-Malik M., Elmgren L., Armstrong J., and Wandeler A.I. A panel of monoclonal antibodies targeting the rabies virus phosphoprotein identifies a highly variable epitope of value for sensitive strain discrimination. J. Clin. Microbiol. 38 (2000) 1397-1403
25. Nahon J.L., Presse F., Bittencourt J.C., Sawchenko P.E., and Vale W. The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology 125 (1989) 2056-2065
26. Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. J. Appl. Physiol. 102 (2007) 241-248
27. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., and Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18 (1998) 9996-10015
28. Redgate E.S., and Gellhorn E. Respiratory activity and the hypothalamus. Am. J. Physiol. 193 (1958) 189-194
29. Rice C.D., Lois J.H., Kerman I.A., and Yates B.J. Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat. Brain Res. 1279 (2009) 71-81
30. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
31. Shimada M., Tritos N.A., Lowell B.B., Flier J.S., and Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396 (1998) 670-674
32. Siegel J.M. Hypocretin (orexin): role in normal behavior and neuropathology. Annu. Rev. Psychol. 55 (2004) 125-148
33. Sutcliffe J.G., and de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J. Neurosci. Res. 62 (2000) 161-168
34. Sutcliffe J.G., and de Lecea L. The hypocretins: setting the arousal threshold. Nat. Rev. Neurosci. 3 (2002) 339-349
35. Taheri S., Zeitzer J.M., and Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25 (2002) 283-313
36. Taylor M.M., and Samson W.K. The other side of the orexins: endocrine and metabolic actions. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E13-E17
37. Terada J., Nakamura A., Zhang W., Yanagisawa M., Kuriyama T., Fukuda Y., and Kuwaki T. Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. J. Appl. Physiol. 104 (2008) 499-507
38. Torterolo P., Sampogna S., Morales F.R., and Chase M.H. MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness. Brain Res. 1119 (2006) 101-114
39. Tritos N.A., and Maratos-Flier E. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides 33 (1999) 339-349
40. Verret L., Goutagny R., Fort P., Cagnon L., Salvert D., Leger L., Boissard R., Salin P., Peyron C., and Luppi P.H. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci. 4 (2003) 19
41. Watson Jr. R.E., Wiegand S.J., Clough R.W., and Hoffman G.E. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides 7 (1986) 155-159
42. Willie J.T., Chemelli R.M., Sinton C.M., and Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 24 (2001) 429-458
43. Winsky-Sommerer R., Boutrel B., and De Lecea L. The role of the hypocretinergic system in the integration of networks that dictate the states of arousal. Drug News Perspect. 16 (2003) 504-512
44. Xi M.C., Fung S.J., Yamuy J., Morales F.R., and Chase M.H. Induction of active (REM) sleep and motor inhibition by hypocretin in the nucleus pontis oralis of the cat. J. Neurophysiol. 87 (2002) 2880-2888
45. Young J.K., Wu M., Manaye K.F., Kc P., Allard J.S., Mack S.O., and Haxhiu M.A. Orexin stimulates breathing via medullary and spinal pathways. J. Appl. Physiol. 98 (2005) 1387-1395
46. Zeitzer J.M., Buckmaster C.L., Parker K.J., Hauck C.M., Lyons D.M., and Mignot E. Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J. Neurosci. 23 (2003) 3555-3560
47. Zhang J.H., Sampogna S., Morales F.R., and Chase M.H. Orexin (hypocretin)-like immunoreactivity in the cat hypothalamus: a light and electron microscopic study. Sleep 24 (2001) 67-76
48. Zhang J.H., Sampogna S., Morales F.R., and Chase M.H. Co-localization of hypocretin-1 and hypocretin-2 in the cat hypothalamus and brainstem. Peptides 23 (2002) 1479-1483
49. Zhang J.H., Sampogna S., Morales F.R., and Chase M.H. Distribution of hypocretin (orexin) immunoreactivity in the feline pons and medulla. Brain Res. 995 (2004) 205-217
50. Zhang W., Fukuda Y., and Kuwaki T. Respiratory and cardiovascular actions of orexin-A in mice. Neurosci. Lett. 385 (2005) 131-136
51. Zhang W., Shimoyama M., Fukuda Y., and Kuwaki T. Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice. Auton. Neurosci. 126-127 (2006) 139-145