Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness

Journal of Physiology

Volumn 587, Issue 9, 2009, Pages 2059-2067

  Dias, Mirela Barros ^a   Li, Aihua ^a   Nattie, Eugene E ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; OREXIN 1 RECEPTOR; CARBON DIOXIDE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; BREATHING RATE; CARBON DIOXIDE BREATHING; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; DRUG EFFICACY; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HYPERCAPNIA; HYPERVENTILATION; LUNG PRESSURE; LUNG VENTILATION; MALE; MICRODIALYSIS; NONHUMAN; NONREM SLEEP; OXYGEN CONSUMPTION; PLETHYSMOGRAPH; PRIORITY JOURNAL; RAT; RETROTRAPEZOID NUCLEUS; SLEEP APNEA SYNDROME; TIDAL VOLUME; WAKEFULNESS; ADULT; APNEA; BODY PLETHYSMOGRAPHY; BRAIN NUCLEUS; BREATHING; SLEEP; TRANSGENIC MOUSE;

ANIMALS; BENZOXAZOLES; HYPERCAPNIA; MALE; NEURAL INHIBITION; PULMONARY VENTILATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RESPIRATORY CENTER; UREA; WAKEFULNESS;

EID: 65449121472     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.168260     Document Type: Article

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