Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 10, 2010, Pages 3551-3558

  Branowska, Danuta ^a   Farahat, Abdelbasset A ^a   Kumar, Arvind ^a   Wenzler, Tanja ^b   Brun, Reto ^b   Liu, Yang ^a   Wilson, W David ^a   Boykin, David W ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Antiprotozoals; Diamidines; Minor groove binders

Indexed keywords

2 (3 AMIDINOPYRIDIN 6 YL) 5 (2 AMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2 (4 AMIDINOPHENYL) 5 (2 AMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2 (4 CYANOPHENYL) 5 (2 CYANOPYRIDIN 5 YL)THIAZOLE; 2 (4 N HYDROXYAMIDINOPHENYL) 5 (2 N HYDROXYAMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (2 N HYDROXYAMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (2 N METHOXYAMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (3 AMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (3 N HYDROXYAMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (3 N METHOXYAMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (4 N HYDROXYAMIDINOPHENYL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS (4 N METHOXYAMIDINOPHENYL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS(2 AMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS(2 CYANOPYRIDIN 5 YL)THIAZOLE; 2,5 BIS(3 CYANOPYRIDIN 6 YL)THIAZOLE; 2,5 BIS(4 AMINOPHENYL)THIAZOLE DIHYDROCHLORIDE; 2,5 BIS(4 CYANOPHENYL)THIAZOLE; 5 (2 CYANOPYRIDIN 5 YL) 2 (3 CYANOPYRIDIN 6 YL)THIAZOLE; 5 (4 AMIDINOPHENYL) 2 (2 AMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 5 (4 AMIDINOPHENYL) 2 (3 AMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; 5 (4 CYANOPHENYL) 2 (2 CYANOPYRIDIN 5 YL)THIAZOLE; 5 (4 CYANOPHENYL) 2 (3 CYANOPYRIDIN 6 YL)THIAZOLE; 5 (4 N HYDROXYAMIDINOPHENYL) 2 (3 N HYDROXYAMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; 5 (4 N HYDROXYAMIDINOPHENYL) 2(2 N HYDROXYAMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 5 (4 N METHOXYAMIDINOPHENYL) 2 (2 N METHOXYAMIDINOPYRIDIN 5 YL)THIAZOLE DIHYDROCHLORIDE; 5 (4 N METHOXYAMIDINOPHENYL) 2 (3 N METHOXYAMIDINOPYRIDIN 6 YL)THIAZOLE DIHYDROCHLORIDE; ANTIPROTOZOAL AGENT; DIAMIDINE DERIVATIVE; HYDROXYLAMINE; PAFURAMIDINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; METHYLATION; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; TRYPANOSOMA RHODESIENSE;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; DISEASE MODELS, ANIMAL; DNA, PROTOZOAN; DRUG STABILITY; MALARIA, FALCIPARUM; MICE; PARASITIC SENSITIVITY TESTS; PENTAMIDINE; PLASMODIUM FALCIPARUM; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI;

EID: 77953131947     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.058     Document Type: Article

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