Novel estrone mimetics with high 17β-HSD1 inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 10, 2010, Pages 3494-3505

  Oster, Alexander ^a   Klein, Tobias ^a   Werth, Ruth ^a   Kruchten, Patricia ^a   Bey, Emmanuel ^a   Negri, Matthias ^a   Marchais Oberwinkler, Sandrine ^a   Frotscher, Martin ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

17 Hydroxysteroid dehydrogenase 1 (17 HSD1) inhibitors; Endometriosis; Estrone mimetics; Ligand and structure based design

Indexed keywords

1 [5 (3' HYDROXYBIPHENYL 3 YL) 2 THIENYL]ETHANONE; 1 [5 (3' HYDROXYBIPHENYL 4 YL) 2 THIENYL]ETHANONE; 3 [2 (2 THIENYL)PYRIDIN 4 YL]PHENOL; 3 [2 (5 CHLORO 2 THIENYL)PYRIDIN 4 YL]PHENOL; 3 [4 (5 CHLORO 2 THIENYL)PYRIDIN 4 YL]PHENOL; 3 [5 (5 CHLORO 2 THIENYL)PYRIDIN 4 YL]PHENOL; 3 [6 (5 CHLORO 2 THIENYL)PYRIDIN 4 YL]PHENOL; 3' (1 BENZOTHIEN 2 YL)BIPHENYL 3 OL; 3' (2 THIENYL)BIPHENYL 3 OL; 3' (5 CHLORO 2 THIENYL)BIPHENYL 3 OL; 3' (5 METHYL 2 THIENYL)BIPHENYL 3 OL; 4' (2 MORPHOLIN 4 YLETHOXY)BIPHENYL 3 OL; 4' (2 THIENYL)BIPHENYL 3 OL; 4' (3 FURYL)BIPHENYL 3 OL; 4' (3 THIENYL)BIPHENYL 3 OL; 4' (5 CHLORO 2 THIENYL)BIPHENYL 3 OL; 4' (6 METHOXYPYRIDIN 3 YL)BIPHENYL 3 OL; 4' MORPHOLIN 4 YLBIPHENYL 3 OL; 5 (3' HYDROXYBIPHENYL 4 YL)PYRIDIN 2(1H) ONE; ANTIESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTRONE; HYDROXYBIPHENYL; OXIDOREDUCTASE INHIBITOR; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MOLECULAR DOCKING; PLACENTA; PROTEIN INTERACTION;

17-HYDROXYSTEROID DEHYDROGENASES; ANTINEOPLASTIC AGENTS, HORMONAL; BIOMIMETICS; BREAST NEOPLASMS; COMPUTER SIMULATION; DRUG DESIGN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; ESTRONE; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953131205     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.065     Document Type: Article

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