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Volumn 7, Issue 20, 2005, Pages 4483-4486

Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AZO COMPOUND; PYRAZOLE; PYRAZOLE DERIVATIVE;

EID: 26444449891     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol051839s     Document Type: Article
Times cited : (23)

References (36)
  • 1
    • 0037192455 scopus 로고    scopus 로고
    • (a) Lehn, J.-M. Science 2002, 295, 2400.
    • (2002) Science , vol.295 , pp. 2400
    • Lehn, J.-M.1
  • 30
    • 26444595274 scopus 로고    scopus 로고
    • note
    • 2Ph, 90%.
  • 31
    • 26444517170 scopus 로고    scopus 로고
    • note
    • 4), filtered, and concentrated in vacuo. The residue was analyzed by GC using dimethoxyphenol as an internal standard, or alternatively, by LC-MS.
  • 34
    • 26444501747 scopus 로고    scopus 로고
    • note
    • We currently do not know the exact mechanism of the exchange process. Both a direct metathesis as well as an exchange reaction mediated by small amounts of hydrolyzed intermediates are feasible.
  • 35
    • 26444604543 scopus 로고    scopus 로고
    • note
    • Compound 14a was synthesized from hydrazide 5 and cyclohexanone in EtOH at rt in 70% yield.
  • 36
    • 0031076776 scopus 로고    scopus 로고
    • The optimal pH stability of many biological targets ranges from pH 4 to 8; therefore, DCLs of pyrazolotriazinones can be directly exposed to proteins in order to discover new binding agents. Schaefer, M.; Sommer, M.; Karplus, M. J. Phys. Chem. B 1997, 101, 1663.
    • (1997) J. Phys. Chem. B , vol.101 , pp. 1663
    • Schaefer, M.1    Sommer, M.2    Karplus, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.