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26444595274
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note
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2Ph, 90%.
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31
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26444517170
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note
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4), filtered, and concentrated in vacuo. The residue was analyzed by GC using dimethoxyphenol as an internal standard, or alternatively, by LC-MS.
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33
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0032506975
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(b) Perrin, C. L.; Fabian, M. A.; Rivero, I. A. J. Am. Chem. Soc. 1998, 120, 1044.
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34
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26444501747
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note
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We currently do not know the exact mechanism of the exchange process. Both a direct metathesis as well as an exchange reaction mediated by small amounts of hydrolyzed intermediates are feasible.
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35
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26444604543
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note
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Compound 14a was synthesized from hydrazide 5 and cyclohexanone in EtOH at rt in 70% yield.
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36
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0031076776
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The optimal pH stability of many biological targets ranges from pH 4 to 8; therefore, DCLs of pyrazolotriazinones can be directly exposed to proteins in order to discover new binding agents. Schaefer, M.; Sommer, M.; Karplus, M. J. Phys. Chem. B 1997, 101, 1663.
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Karplus, M.3
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