Dendritic cell-mediated HIV-1 infection of T cells demonstrates a direct relationship to plasma viral RNA levels

Journal of Acquired Immune Deficiency Syndromes

Volumn 54, Issue 2, 2010, Pages 115-121

  Arora, Reetakshi ^a   Bull, Lara ^b   Siwak, Edward B ^a   Thippeshappa, Rajesh ^a   Arduino, Roberto C ^b   Kimata, Jason T ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

CCR5; CD4; Dendritic cells; HIV 1; Replication capacity; Viral burden

Indexed keywords

ANTIGEN P24; CHEMOKINE RECEPTOR CCR5; LUCIFERASE; NEF PROTEIN; VIRUS RNA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL INTERACTION; CLINICAL ARTICLE; COCULTURE; COHORT ANALYSIS; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; FEMALE; HOST; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE CULTURE; MALE; MOLECULAR CLONING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; T LYMPHOCYTE; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS ISOLATION; VIRUS LOAD; VIRUS REPLICATION;

ADULT; CD4 LYMPHOCYTE COUNT; DENDRITIC CELLS; FEMALE; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; RECEPTORS, CCR5; RNA, VIRAL; T-LYMPHOCYTES; VIRAL LOAD; VIRUS REPLICATION;

EID: 77953083289     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181daaf98     Document Type: Article

References (42)

1. Mellors JW, Kingsley LA, Rinaldo CR Jr, et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med. 1995;122:573-579.
2. Mellors JW, Rinaldo CR Jr, Gupta P, et al. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science. 1996;272:1167-1170.
3. O'Brien WA, Hartigan PM, Martin D, et al. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS. N Engl J Med. 1996; 334:426-431.
4. Desrosiers RC. Strategies used by human immunodeficiency virus that allow persistent viral replication. Nat Med. 1999;5:723-725.
5. Piatak M Jr, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 1993;259:1749-1754.
6. Gonzalez E, Kulkarni H, Bolivar H, et al. The influence of CCL3L1 genecontaining segmental duplications on HIV-1/AIDS susceptibility. Science. 2005;307:1434-1440.
7. Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Part 2: genetic factors and implications for antiretroviral therapeutics. Ann Intern Med. 2001;134:978-996.
8. Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Part 1: cellular and humoral immune responses. Ann Intern Med. 2001;134(9 Pt 1):761-776.
9. Kimata JT. HIV-1 fitness and disease progression: insights from the SIV- macaque model. Curr HIV Res. 2006;4:65-77.
10. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377.
11. Wu L, KewalRamani VN. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat Rev Immunol. 2006;6:859-868.
12. Hladik F, McElrath MJ. Setting the stage: host invasion by HIV. Nat Rev Immunol. 2008;8:447-457.
13. McDonald D, Wu L, Bohks SM, et al. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 2003;300:1295-1297.
14. Cameron PU, Freudenthal PS, Barker JM, et al. Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science. 1992;257:383-387.
15. Gummuluru S, KewalRamani VN, Emerman M. Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover. J Virol. 2002;76: 10692-10701.
16. Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759.
17. Haase AT. Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol. 2005;5:783-792.
18. Pantaleo G, Graziosi C, Demarest JF, et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature. 1993;362:355-358.
19. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med. 1996;2: 1240-1243.
20. Hollinger FB, Bremer JW, Myers LE, et al. Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. The NIH/NIAID/DAIDS/ACTG Virology Laboratories. J Clin Microbiol. 1992;30:1787-1794.
21. Kimata JT, Gosink JJ, KewalRamani VN, et al. Coreceptor specificity of temporal variants of simian immunodeficiency virus Mne. J Virol. 1999; 73:1655-1660.
22. Yu Kimata MT, Cella M, Biggins JE, et al. Capture and transfer of simian immunodeficiency virus by macaque dendritic cells is enhanced by DC-SIGN. J Virol. 2002;76:11827-11836.
23. Patel PG, Yu Kimata MT, Biggins JE, et al. Highly pathogenic simian immunodeficiency virus mne variants that emerge during the course of infection evolve enhanced infectivity and the ability to downregulate CD4 but not class I major histocompatibility complex antigens. J Virol. 2002; 76:6425-6434.
24. Shugars DC, Smith MS, Glueck DH, et al. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J Virol. 1993; 67:4639-4650.
25. Long EM, Rainwater SM, Lavreys L, et al. HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus. AIDS Res Hum Retroviruses. 2002;18:567-576.
26. Kimata JT, Wilson JM, Patel PG. The increased replicative capacity of a late-stage simian immunodeficiency virus mne variant is evident in macrophageor dendritic cell-T-cell cocultures. Virology. 2004;327: 307-317.
27. Pope M, Betjes MG, Romani N, et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell. 1994;78:389-398.
28. Weissman D, Barker TD, Fauci AS. The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation. J Exp Med. 1996;183:687-692.
29. Kimata JT, Kuller L, Anderson DB, et al. Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression. Nat Med. 1999;5:535-541.
30. Biesinger T, Yu Kimata MT, Kimata JT. Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells. Virology. 2008;370:184-193.
31. Bates M, Wrin T, Huang W, et al. Practical applications of viral fitness in clinical practice. Curr Opin Infect Dis. 2003;16:11-18.
32. Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J Virol. 2001;75:4664-4672. (Pubitemid 32381508)
33. Arrighi JF, Pion M, Garcia E, et al. DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J Exp Med. 2004;200:1279-1288.
34. Wang JH, Janas AM, Olson WJ, et al. CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1. J Virol. 2007;81:2497-2507.
35. Blaak H, Brouwer M, Ran LJ, et al. In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection. J Infect Dis. 1998;177: 600-610. (Pubitemid 28099873)
36. Mariani R, Kirchhoff F, Greenough TC, et al. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol. 1996;70:7752-7764.
37. Premkumar DR, Ma XZ, Maitra RK, et al. The nef gene from a long-term HIV type 1 nonprogressor. AIDS Res Hum Retroviruses. 1996;12:337-345.
38. Fackler OT, Moris A, Tibroni N, et al. Functional characterization of HIV-1 Nef mutants in the context of viral infection. Virology. 2006;351: 322-339.
39. Laguette N, Benichou S, Basmaciogullari S. Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivity. J Virol. 2009;83:1093-1104.
40. Qi M, Aiken C. Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. J Virol. 2007;81:1534-1536.
41. Julg B, Goebel FD. Susceptibility to HIV/AIDS: an individual characteristic we can measure? Infection. 2005;33:160-162.
42. Shao W, Tang J, Song W, et al. CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection. Genes Immun. 2007;8:224-231.