Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: A randomized controlled trial

American Journal of Clinical Nutrition

Volumn 88, Issue 2, 2008, Pages 348-355

  Winkels, Renate M ^a,b   Brouwer, Ingeborg A ^a,b,c   Clarke, Robert ^d   Katan, Martijn B ^c   Verhoef, Petra ^e  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID; TRANSCOBALAMIN;

ADULT; AGED; ARTICLE; BREAD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ELDERLY CARE; FEMALE; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; HUMAN; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NUTRITIONAL STATUS; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

EID: 49449095497     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/88.2.348     Document Type: Article

References (57)

1. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991;338:131-7.
2. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-5.
3. Voedingsraad. Advice concerning folic acid supply in relation to neural tube defects. (Advies inzake foliumzuurvoorziening in relatie tot neuralebuisdefecten.) Den Haag, Netherlands: Voorlichtingsbureau voor de Voeding, 1992 (in Dutch).
4. Voedingsraad/Gezondheidsraad. Follow-up advice concerning folic acid supply in relation to neural tube defects. Vervolgadvies inzake foliumzuurvoorziening in relatie tot neuralebuisdefecten. Den Haag, Netherlands: Voorlichtingsbureau voor de Voeding, 1993 (in Dutch).
5. Scientific Advisory Committee on Nutrition. Folate and disease prevention. Norwich, United Kingdom: The Stationery Office, 2006:1-211.
6. Abramsky L, Dolk H. Should Europe fortify a staple food with folic acid? Lancet 2007;369:641-2.
7. Czernichow S, Noisette N, Blacher J, et al. Case for folic acid and vitamin B12 fortification in Europe. Semin Vasc Med 2005;5:156-62.
8. De Walle HEK, De Jong-Van Den Berg LTW. Growing gap in folic acid intake with respect to level of education in the Netherlands. Community Genetics 2007;10:93-6.
9. Eurocat Folic Acid Working Group. Special report: prevention of neural tube defects by periconceptional folic acid supplementation in Europe (December 2005). 2005: Internet: http://www.eurocat.ulster.ac.uk/pubdata/Folic-Acid.html. Accessed May 9, 2007.
10. Health Council of the Netherlands. Risks of folic acid fortification. The Hague, Netherlands: Health Council of the Netherlands, 2000:48.
11. Committee on Medical Aspects of Food and Nutrition Policy (COMA). Folic acid and the prevention of disease. Report on health and social subjects. United Kingdom: Department of Health, 2000.
12. van Asselt DZ, de Groot LC, van Staveren WA, et al. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998;68:328-34.
13. Clarke R, Grimley Evans J, Schneede J, et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33:34-41.
14. Clarke R, Refsum H, Birks J, et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr 2003;77:1241-7.
15. Recommended levels of folic acid and vitamin B12 fortification: conclusions. Nutr Rev 2004;62(suppl):S62-6.
16. Oakley GP Jr. Let's increase folic acid fortification and include vitamin B-12. Am J Clin Nutr 1997;65:1889-90.
17. Dhonukshe-Rutten RA, van Zutphen M, de Groot LC, Eussen SJ, Blom HJ, van Staveren WA. Effect of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons. Am J Clin Nutr 2005;82:568-74.
18. Eussen SJ, de Groot LC, Clarke R, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005;165:1167-72.
19. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927-33.
20. Woodside JV, Yarnell JW, McMaster D, et al. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr 1998;67:858-66.
21. Blacher J, Czernichow S, Raphael M, et al. Very low oral doses of vitamin B-12 increase serum concentrations in elderly subjects with food-bound vitamin B-12 malabsorption. J Nutr 2007;137:373-8.
22. Seal EC, Metz J, Flicker L, Melny J. A randomized, double-blind, placebo-controlled study of oral vitamin B12 supplementation in older patients with subnormal or borderline serum vitamin B12 concentrations. J Am Geriatr Soc 2002;50:146-51.
23. Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH. Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr 2004;79:805-11.
24. Stover PJ. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 2004;62(suppl):S3-12; discussion S13.
25. Institute of Medicine. Vitamin B12. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press, 2000:306-356, 527-30.
26. Bor MV, Lydeking-Olsen E, Moller J, Nexo E. A daily intake of approximately 6 μg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. Am J Clin Nutr 2006;83:52-8.
27. van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. Am J Clin Nutr 2003;77:1318-23.
28. oedingscentrum. Results of the Dutch Nutrition Survey 1998. (Zo eet Nederland 1998. Resultaten van de Voedselconsumptiepeiling 1998.) Delft, Netherlands: Voedingscentrum, 1998 (in Dutch).
29. Kistemaker C, Bouman M, Hulshof KFAM. The consumption of separate products by Dutch population groups - Dutch Nutrition Survey 1997-1998. (De consumptie van afzonderlijke producten door Nederlandse bevolkingsgroepen - Voedselconsumptiepeiling 1997-1998.) TNO-report V98.812. Zeist, Netherlands: Stiching Voedingscentrum Nederland, 1998 (in Dutch).
30. Johansson M, Witthoft CM, Bruce A, Jagerstad M. Study of wheat breakfast rolls fortified with folic acid. The effect on folate status in women during a 3-month intervention. Eur J Nutr 2002;41:279-86.
31. Pfeiffer CM, Rogers LM, Bailey LB, Gregory JF III. Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. Am J Clin Nutr 1997;66:1388-97.
32. Blom HJ, Van Rooij A, Hogeveen M. A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med 2007;45:645-50.
33. Ubbink JB, Hayward Vermaak WJ, Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 1991;565:441-6.
34. Brussaard JH, Lowik MR, van den Berg H, Brants HA, Goldbohm RA. Folate intake and status among adults in the Netherlands. Eur J Clin Nutr 1997;51(suppl 3):S46-50.
35. Clarke R, Sherliker P, Hin H, et al. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clin Chem 2007;53:963-70.
36. Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency - an update. Haematologica 2006;91:1506-12.
37. Refsum H, Johnston C, Guttormsen AB, Nexo E. Holotranscobalamin and total transcobalamin in human plasma: determination, determinants, and reference values in healthy adults. Clin Chem 2006;52:129-37.
38. Thorpe SJ, Heath A, Blackmore S, et al. International standard for serum vitamin B(12) and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B(12) and folate content. Clin Chem Lab Med 2007;45:380-6.
39. Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH, Jacques PF. Folic acid intake from fortification in United States exceeds predictions. J Nutr 2002;132:2792-8.
40. Quinlivan EP, Gregory JF III. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 2003;77:221-5.
41. Centers for Disease Control and Prevention. Spina bifida and anencephaly before and after folic acid mandate-United States, 1995-1996 nad 1999-2000. MMWR Morb Mortal Wkly Rep 2004;53:362-5.
42. Mills JL, Signore C. Neural tube defect rates before and after food fortification with folic acid. Birth Defects Res A Clin Mol Teratol 2004;70:844-5.
43. Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004;328:211-4.
44. Molloy AM, Scott JM. Folates and prevention of disease. Public Health Nutr 2001;4:601-9.
45. Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007;369:208-16.
46. Hin H, Clarke R, Sherliker P, et al. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Aging 2006;35:416-22.
47. Ray JG, Wyatt PR, Thompson MD, et al. Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. Epidemiology 2007;18:362-6.
48. Clarke RJ. Homocysteine-lowering trials for prevention of cardiovascular events: A review of the design and power of the large randomized trials. Am Heart J 2006;151:282-7.
49. Eussen SJ, de Groot LC, Joosten LW, et al. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am J Clin Nutr 2006;84:361-70.
50. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Ann Rev Nutr 1999;19:357-7.
51. Kim YI. Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 2004;80:1123-8.
52. Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 2007;16:1325-9.
53. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.
54. Rosenberg IH. Science-based micronutrient fortification: which nutrients, how much, and how to know? Am J Clin Nutr 2005;82:279-80.
55. Sweeney MR, McPartlin J, Scott JM. Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum. BMC Public Health 2007;7:41.
56. Carmel R. Malabsorption of food cobalamin. Bailliere's Clin Haematology 1995;8:639-55.
57. Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 2004;24:299-326.