Effects of folate and vitamin B12 on cognitive function in adults and the elderly

Food and Nutrition Bulletin

Volumn 29, Issue 2 SUPPL., 2008, Pages

  Rosenberg, Irwin H ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Adults; Cognitive function; Elderly; Folate; Vitamin B12

Indexed keywords

ADULT; COGNITION; CONFERENCE PROCEEDING; ELDERLY POPULATION; VITAMIN;

EID: 48249139847     PISSN: 03795721     EISSN: None     Source Type: Journal    
DOI: 10.1177/15648265080292s118     Document Type: Conference Paper

References (71)

1. Balk E, Chung M, Raman G, Tatsioni A, Chew P, Ip S, DeVine D, Lau J. B vitamins and berries and age-related neurodegenerative disorders. Evidence Report/Technology Assessment No. 134. (Prepared by Tufts-New England Medical Center Evidence-based Practice Center under Contract No. 290-02-0022). AHRQ Publication No. 06-E008. Rockville, MD: Agency for Healthcare Research and Quality. April 2006. Available at: http:// www.ahrq.gov/downloads/pub/evidence/pdf/berry/berry.pdf. Accessed 18 March 2008.
2. Deijen JB, Slump E, Wouters-Wesseling W, De Groot CP, Galle E, Pas H. Nutritional intake and daily functioning of psychogeriatric nursing home residents. J Nutr Health Aging 2003;7:242-6.
3. 6 and folate intake in AD and healthy aging. J Nutr Health Aging 2003;7:160-5.
4. 6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 2002; 132:1345-56.
5. Goodwin JS, Goodwin JM, Garry PJ. Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 1983;249:2917-21.
6. Lee L, Kang SA, Lee HO, Lee BH, Park JS, Kim JH, Jung IK, Park YJ, Lee JE. Relationships between dietary intake and cognitive function level in Korean elderly people. Public Health 2001;115:133-8.
7. Renvall MJ, Spindler AA, Ramsdell JW, Paskvan M. Nutritional status of free-living Alzheimer's patients. Am J Med Sci 1989;298:20-7.
8. Requejo AM, Ortega RM, Robles F, Navia B, Faci M, Aparicio A. Influence of nutrition on cognitive function in a group of elderly, independently living people. Eur J Clin Nutr 2003;57(suppl 1):S54-7.
9. 12 intake and cognitive decline among community-dwelling older persons. Arch Neurol 2005;62:641-5.
10. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
11. Wang HX, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L. Vitamin B(12) and folate in relation to the development of Alzheimer's disease. Neurology 2001; 56:1188-94.
12. Bowirrat A, Friedland RP, Farrer L, Baldwin C, Korczyn A. Genetic and environmental risk factors for Alzheimer's disease in Israeli Arabs. J Mol Neurosci 2002;1-2:239-45.
13. Clarke R, Harrison G, Richards S, Vital Trial Collaborative Group. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med 2003; 254:67-75.
14. 12 and folate in patients with dementia. Int J Geriatr Psychiatry 2004;19:365-70.
15. 12 plasma concentrations in Alzheimer disease. Neuroendocrinol Lett 2004; 25:176-7.
16. 12 levels in elderly patients with progressive dementia. Am J Geriatr Psychiatry 2002;10:321-7.
17. 12, folate and the cognitive ability of the Thai rural elderly. J Med Assoc Thai 1997;80:700-5.
18. Scileppi KP, Blass JP, Baker HG. Circulating vitamins in Alzheimer's dementia as compared with other dementias. J Am Geriatr Soc 1984;32:709-11.
19. Coimbra CG, Junqueira VB. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. Braz J Med Biol Res 2003;36:1409-17.
20. Woitalla D, Kuhn W, Muller T. MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease. J Neural Transm Suppl 2004;68:15-20.
21. Andersen-Ranberg K, Vasegaard L, Jeune B. Dementia is not inevitable: A population-based study of Danish centenarians. J Gerontol B Psychol Sci Soc Sci 2001;56:P152-9.
22. Anello G, Gueant-Rodriguez RM, Bosco P, Gueant JL, Romano A, Namour B, Spada R, Caraci F, Pourie G, Daval JL, Ferri R. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. Neuroreport 2004;15:859-61.
23. Argyriadou S, Vlachonikolis I, Melisopoulou H, Katachanakis K, Lionis C. In what extent anemia coexists with cognitive impairment in elderly: A cross-sectional study in Greece. BMC Fam Pract 2001;2:5.
24. Cacabelos R, Fernandez-Novoa L, Corzo L, Pichel V, Lombardi V, Kubota Y. Genomics and phenotypic profiles in dementia: Implications for pharmacological treatment. Methods Find Exp Clin Pharmacol 2004;26:421-44.
25. 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998; 55:1449-55.
26. Gottfries J, Blennow K, Lehmann MW, Regland B, Gottfries CG. One-carbon metabolism and other biochemical correlates of cognitive impairment as visualized by principal component analysis. J Geriatr Psychiatry Neurol 2001;14:109-14.
27. 12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 1997;52:M76-9.
28. McCaddon A, Blennow K, Hudson P, Hughes A, Barber J, Gray R, Davies G, Williams JH, Duguid J, Lloyd A, Tandy S, Everall M, Cattell H, McCaddon A, Ellis D, Palmer M, Bogdanovic N, Gottfries CG, Zetterberg H, Rymo L, Regland B. Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dement Geriatr Cogn Disord 2004;71:215-21.
29. 12 and folate in Alzheimer's patients and healthy Arabs in Israel. J Neurol Sci 2004;227:109-13.
30. Nilsson K, Gustafson L, Faldt R, Andersson A, Brattstrom L, Lindgren A, Israelsson B, Hultberg B. Hyperhomocysteinaemia - a common finding in a psychogeriatric population. Eur J Clin Invest 1996; 26:853-9.
31. Postiglione A, Milan G, Ruocco A, Gallotta G, Guiotto G, Di Minno G. Plasma folate, vitamin B(12), and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study. Gerontology 2001;47:324-9.
32. 12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 2004; 80:114-22.
33. Ravaglia G, Forti P, Maioli F, Muscari A, Sacchetti L, Arnone G, Nativio V, Talerico T, Mariani E. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr 2003;77:668-73.
34. 12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003;74:959-61.
35. 12 levels related to high activity of platelet MAO in patients with dementia disorders. A retrospective study. Acta Psychiatr Scand 1988;78:451-7.
36. Religa D, Styczynska M, Peplonska B, Gabryelewicz T, Pfeffer A, Chodakowska M, Luczywek E, Wasiak B, Stepien K, Golebiowski M, Winblad B, Barcikowska M. Homocysteine, apolipoproteine E and methylenetetrahydrofolate reductase in Alzheimer's disease and mild cognitive impairment. Dement Geriatr Cogn Disord 2003;16:64-70.
37. 12 levels in Israeli elders admitted to a geriatric hospital. J Nutr Health Aging 2001;5:124-7.
38. Tripathi M, Sheshadri S, Padma MV, Jain S, Meheshwari MC, Behari M. Serum cobalamin levels in dementias. Neurol India 2001;49:284-6.
39. Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: Findings from the Nun study. Am J Clin Nutr 2000;71:993-8.
40. 6, and vascular disease in AD patients. Neurology 2002; 58:1471-5.
41. Nagga K, Rajani R, Mardh E, Borch K, Mardh S, Marcusson J. Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia. Dement Geriatr Cogn Disord 2003;16:269-75.
42. Nilsson SE, Takkinen S, Tryding N, Evrin PE, Berg S, McClearn G, Johansson B. Association of biochemical values with morbidity in the elderly: A population-based Swedish study of persons aged 82 or more years. Scand J Clin Lab Invest 2003;63:457-66.
43. Serot JM, Christmann D, Dubost T, Bene MC, Faure GC. CSF-folate levels are decreased in late-onset AD patients. J Neural Transm 2001;108:93-9.
44. Maxwell CJ, Hogan DB, Ebly EM. Serum folate levels and subsequent adverse cerebrovascular outcomes in elderly persons. Dement Geriatr Cogn Disord 2002;13:225-34.
45. Stewart R, Asonganyi B, Sherwood R. Plasma homocysteine and cognitive impairment in an older British African-Caribbean population. J Am Geriatr Soc 2002;50:1227-32.
46. Jones S, Small BJ, Fratiglioni L, Backman L. Predictors of cognitive change from preclinical to clinical Alzheimer's disease. Brain Cogn 2002;49:210-3.
47. Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: The Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005;82:627-35.
48. 6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 1996; 63:306-14.
49. 12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005;118:161-7.
50. 12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging 2002;6:254-60.
51. Carmel R, Gott PS, Waters CH, Cairo K, Green R, Bondareff W, DeGiorgio CM, Cummings JL, Jacobsen DW, Buckwalter G. The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995;54:245-53.
52. 12 treatment on cognitive function and depression: A randomized placebo controlled study. J Affect Disord 2004;81:269-73.
53. Ikeda T, Yamamoto K, Takahashi K, Kaku Y, Uchiyama M, Sugiyama K, Yamada M. Treatment of Alzheimer-type dementia with intravenous mecobalamin. Clin Ther 1992;14:426-37.
54. 12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia. Psychiatry Clin Neurosci 2001; 55:281-2.
55. 12 and folic acid to memory function. Biol Psychiatry 1970; 2:19-26.
56. Kwok T, Tang C, Woo J, Lai WK, Law LK, Pang CP. Randomized trial of the effect of supplementation on the cognitive function of older people with subnormal cobalamin levels. Int J Geriatr Psychiatry 1998;13:611-6.
57. Martin DC, Francis J, Protetch J, Huff FJ. Time dependency of cognitive recovery with cobalamin replacement: Report of a pilot study. J Am Geriatr Soc 1992;40:168-72.
58. 12 treatment - preliminary study. Jpn J Psychiatry Neurol 1988;42:65-71.
59. 12 concentrations. J Am Geriatr Soc 2002;50:146-51.
60. 12: Effects of replacement therapy on dementia. J Neurol 1996; 243:522-9.
61. van Asselt DZ, Pasman JW, van Lier HJ, Vingerhoets DM, Poels PJ, Kuin Y, Blom HJ, Hoefnagels WH. Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons. J Gerontol A Biol Sci Med Sci 2001;56:M775-9.
62. Sommer BR, Hoff AL, Costa M. Folic acid supplementation in dementia: A preliminary report. J Geriatr Psychiatry Neurol 2003;16:156-9.
63. Fioravanti M, Ferrario E, Massaia M, Cappa G, Rivolta G, Grossi E, Buckley AE. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatrics 1997;26:1-13.
64. McGeer PL, Zeldowicz L, McGeer EG. A clinical trial of folic acid in Parkinson's disease. Can Med Assoc J 1972; 106:145-6.
65. Rapin JR, LePoncin M, Grebyl J. Blood folates deficiencies and cognitive functions in aging. Trends Biomed Gerontol 1988;1:315-23.
66. Durga J, van Boxtel MPJ, Schouten EG, Jolles J, Kok FJ, Verhoef P. The effect of 3-year folic acid supplementation on cognitive function. A randomized controlled trial. Haematologica Reports 2005;1(3):1 (abstract S001).
67. Lewerin C, Matousek M, Steen G, Johansson B, Steen B, Nilsson-Ehle H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: A placebo-controlled randomized study. Am J Clin Nutr 2005;81:1155-62.
68. Shaw DM, Macsweeney DA, Johnson AL, O'Keeffe R, Naidoo D, Macleod DM, Jog S, Preece JM, Crowley JM. Folate and amine metabolites in senile dementia: A combined trial and biochemical study. Psychol Med 1971;1:166-71.
69. Aisen PS, Egelko S, Andrews H, Diaz-Arrastia R, Weiner M, DeCarli C, Jagust W, Miller JW, Green R, Bell K, Sano M. A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry 2003;11:246-9.
70. 6-folate treatment improves blood-brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment. Dement Geriatr Cogn Disord 2003;16:145-50.
71. Nilsson K, Gustafson L, Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 2001;16:609-14.