Selectively targeting pain in the trigeminal system

Pain

Volumn 150, Issue 1, 2010, Pages 29-40

  Kim, Hyun Yeong ^a   Kim, Kihwan ^a   Li, Hai Ying ^a   Chung, Gehoon ^a   Park, Chul Kyu ^a   Kim, Joong Soo ^a   Jung, Sung Jun ^b   Lee, Min Kyung ^c   Ahn, Dong Kuk ^c   Hwang, Se Jin ^b   Kang, Youngnam ^d   Binshtok, Alexander M ^e   Bean, Bruce P ^f   Woolf, Clifford J ^e   Oh, Seog Bae ^a  

^a School of Dentistry and Dental Research Institute   (South Korea)

^b Hanyang University   (South Korea)

^c Kyungpook National University   (South Korea)

^d OSAKA UNIVERSITY   (Japan)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Action potentials; Local anesthetics; QX 314; Trigeminal system; TRPV1; Voltage gated sodium channels

Indexed keywords

ANALGESIC AGENT; CAPSAICIN; LIDOCAINE ETHOBROMIDE; VOLTAGE GATED SODIUM CHANNEL;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ELECTROSTIMULATION; EXPERIMENTAL RAT; IMMUNOHISTOCHEMISTRY; JAW OPENING REFLEX; MALE; MESENCEPHALON; MOTOR PERFORMANCE; NERVE CELL; NERVE POTENTIAL; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROPRIOCEPTION; RAT; SIGNAL DETECTION; SPRAGUE DAWLEY RAT; TRIGEMINAL NERVE; TRIGEMINUS GANGLION; TRIGEMINUS NEURALGIA;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; ANIMALS; CAPSAICIN; ELECTRIC STIMULATION; LIDOCAINE; MICE; MICE, KNOCKOUT; NEURONS; NOCICEPTORS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; TRIGEMINAL GANGLION; TRPV CATION CHANNELS;

EID: 77953022495     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.02.016     Document Type: Article

References (37)

1. Baranowski R., Lynn B., and Pini A. The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br J Pharmacol 89 (1986) 267-276
2. Bernardini N., Neuhuber W., Reeh P.W., and Sauer S.K. Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Neuroscience 126 (2004) 585-590
3. Binshtok A.M., Bean B.P., and Woolf C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449 (2007) 607-610
4. Binshtok A.M., Gerner P., Oh S.B., Puopolo M., Suzuki S., Roberson D.P., Herbert T., Wang C.F., Kim D., Chung G., Mitani A.A., Wang G.K., Bean B.P., and Woolf C.J. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology 111 (2009) 127-137
5. Butterworth J., and Oxford G.S. Local anesthetics: a new hydrophilic pathway for the drug-receptor reaction. Anesthesiology 111 (2009) 12-14
6. Butterworth J., and Strichartz G.R. Molecular mechanisms of local anesthesia: a review. Anesthesiology 72 (1990) 711-734
7. Caterina M.J., and Julius D. Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol 9 (1999) 525-530
8. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., and Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389 (1997) 816-824
9. Chen J., Kim D., Bianchi B.R., Cavanaugh E.J., Faltynek C.R., Kym P.R., and Reilly R.M. Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain 5 (2009) 3
10. Chung J.M., Lee K.H., Hori Y., and Willis W.D. Effects of capsaicin applied to a peripheral nerve on the responses of primate spinothalamic tract cells. Brain Res 329 (1985) 27-38
11. Chung M.K., Guler A.D., and Caterina M.J. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat Neurosci 11 (2008) 555-564
12. Cummins T.R., Sheets P.L., and Waxman S.G. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain 131 (2007) 243-257
13. Fang Z., Park C.K., Li H.Y., Kim H.Y., Park S.H., Jung S.J., Kim J.S., Monteil A., Oh S.B., and Miller R.J. Molecular basis of Ca(v)2.3 calcium channels in rat nociceptive neurons. J Biol Chem 282 (2007) 4757-4764
14. Fried K., Bongenhielm U., Boissonade F.M., and Robinson P.P. Nerve injury-induced pain in the trigeminal system. Neuroscientist 7 (2001) 155-165
15. Gold M.S., Reichling D.B., Hampl K.F., Drasner K., and Levine J.D. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 285 (1998) 413-421
16. + current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus. J Neurophysiol 97 (2007) 2385-2393
17. Leffler A., Fischer M.J., Rehner D., Kienel S., Kistner K., Sauer S.K., Gavva N.R., Reeh P.W., and Nau C. The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest 118 (2008) 763-776
18. Leston J.M. Functional anatomy of the trigeminal nerve. Neurochirurgie 55 (2009) 99-112
19. Lewis C., Neidhart S., Holy C., North R.A., Buell G., and Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377 (1995) 432-435
20. McCleskey E.W., and Gold M.S. Ion channels of nociception. Annu Rev Physiol 61 (1999) 835-856
21. McDavid S., Verdier D., Lund J.P., and Kolta A. Electrical properties of interneurons found within the trigeminal motor nucleus. Eur J Neurosci 28 (2008) 1136-1145
22. Meyers J.R., MacDonald R.B., Duggan A., Lenzi D., Standaert D.G., Corwin J.T., and Corey D.P. Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci 23 (2003) 4054-4065
23. Miyoshi T., Aida H., and Kaneko Y. Comparative study on anesthetic potency of dental local anesthetics assessed by the jaw-opening reflex in rabbits. Anesth Prog 47 (2000) 35-41
24. Oh S.B., Piao Z.G., Shin S.S., Ren D., Park K., and Kim J.S. GABAergic and serotonergic modulation of calcium currents in rat trigeminal motoneurons. Biochem Biophys Res Commun 309 (2003) 58-65
25. Ohkado S., Ichinohe T., and Kaneko Y. Comparative study on anesthetic potency depending on concentrations of lidocaine and epinephrine: assessment of dental local anesthetics using the jaw-opening reflex. Anesth Prog 48 (2001) 16-20
26. Park C.K., Kim K., Jung S.J., Kim M.J., Ahn D.K., Hong S.D., Kim J.S., and Oh S.B. Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain 144 (2009) 84-94
27. Park C.K., Kim M.S., Fang Z., Li H.Y., Jung S.J., Choi S.Y., Lee S.J., Park K., Kim J.S., and Oh S.B. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem 281 (2006) 17304-17311
28. Petsche U., Fleischer E., Lembeck F., and Handwerker H.O. The effect of capsaicin application to a peripheral nerve on impulse conduction in functionally identified afferent nerve fibres. Brain Res 265 (1983) 233-240
29. + channel. Proc Natl Acad Sci USA 92 (1995) 11839-11843
30. Rigler M.L., Drasner K., Krejcie T.C., Yelich S.J., Scholnick F.T., DeFontes J., and Bohner D. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 72 (1991) 275-281
31. Sessle B.J. Acute and chronic craniofacial pain: brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates. Crit Rev Oral Biol Med 11 (2000) 57-91
32. Stanley F.M. Handbook of local anesthesia 5e (1994), Elsevier Inc., New York, USA
33. Suzuki S., Gerner P., Colvin A.C., and Binshtok A.M. C-fiber-selective peripheral nerve blockade. Open Pain J 2 (2009) 24-29
34. Taddese A., Nah S.Y., and McCleskey E.W. Selective opioid inhibition of small nociceptive neurons. Science 270 (1995) 1366-1369
35. Virginio C., MacKenzie A., Rassendren F.A., North R.A., and Surprenant A. Pore dilation of neuronal P2X receptor channels. Nat Neurosci 2 (1999) 315-321
36. Wang H., and Woolf C.J. Pain TRPs. Neuron 46 (2005) 9-12
37. Wang J.S., Backman J.T., Taavitsainen P., Neuvonen P.J., and Kivisto K.T. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos 28 (2000) 959-965