Integrin β1-dependent invasive migration of irradiation-tolerant human lung adenocarcinoma cells in 3D collagen matrix

Biochemical and Biophysical Research Communications

Volumn 396, Issue 3, 2010, Pages 651-655

  Ishihara, Seiichiro ^a   Haga, Hisashi ^a   Yasuda, Motoaki ^a   Mizutani, Takeomi ^a   Kawabata, Kazushige ^a   Shirato, Hiroki ^b   Nishioka, Takeshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

3D culture; Collagen gel; Integrin 1; Invasion; Irradiation; Lung adenocarcinoma

Indexed keywords

BETA1 INTEGRIN; COLLAGEN;

ARTICLE; CANCER INVASION; CANCER RADIOTHERAPY; CANCER RESISTANCE; CARCINOMA CELL; CELL CLONING; CELL COUNT; CELL MIGRATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; RADIATION DOSE; SPINDLE CELL; ADENOCARCINOMA; CELL MOTION; LUNG TUMOR; METABOLISM; MITOSIS SPINDLE; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ADENOCARCINOMA; ANTIGENS, CD29; CELL LINE, TUMOR; CELL MOVEMENT; COLLAGEN; HUMANS; LUNG NEOPLASMS; MITOTIC SPINDLE APPARATUS; NEOPLASM INVASIVENESS; RADIATION TOLERANCE;

EID: 77953021843     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.04.150     Document Type: Article

References (16)

1. Von Essen C.F. Radiation enhancement of metastasis: a review. Clin. Exp. Metastasis 9 (1991) 77-104
2. Rofstad E.K., Mathiesen B., and Galappathi K. Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor. Cancer Res. 64 (2004) 13-18
3. Tsutsumi K., Tsuda M., Yazawa N., Nakamura H., Ishihara S., Haga H., Yasuda M., Yamazaki R., Shirato H., Kawaguchi H., Nishioka T., and Ohba Y. Increased motility and invasiveness of tumor cells that survived 10 Gy irradiation. Cell Struct. Funct. 34 (2009) 89-96
4. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
5. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
6. Hood J.D., and Cheresh D.A. Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2 (2002) 91-100
7. Wolf K., Mazo I., Leung H., Engelke K., von Andrian U.H., Deryugina E.I., Strongin A.Y., Brocker E.-B., and Friedl P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol. 160 (2003) 267-277
8. Cordes N., Hansmeier B., Beinke C., Meineke V., and van Beuningen D. Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines. Br. J. Cancer 89 (2003) 2122-2132
9. Cordes N., Blaese M.A., Meineke V., and van Beuningen D. Ionizing radiation induces up-regulation of functional β1-integrin in human lung tumour cell lines in vitro. Int. J. Radiat. Biol. 78 (2002) 347-357
10. Seidler J., Durzok R., Brakebusch C., and Cordes N. Interactions of the integrin subunit β1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival. Radiother. Oncol. 76 (2005) 129-134
11. Hall D.E., Reichardt L.F., Crowley E., Holley B., Moezzi H., Sonnenberg A., and Damsky C.H. The α1/β1 and α6/β1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J. Cell Biol. 110 (1990) 2175-2184
12. Yamazaki D., Kurusu S., and Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 96 (2005) 379-386
13. Keely P.J., Westwick J.K., Whitehead I.P., Der C.J., and Parise L.V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390 (1997) 632-636
14. Nishioka T., Yasuda M., Tsutsumi K., Haga H., and Shirato H. Matrixmetalloproteinases: up-regulated in subclones that survived 10-Gy irradiation. Radiat. Med. 25 (2007) 430-431
15. Ning S., Nemeth J.A., Hanson R.L., Forsythe K., and Knox S.J. Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo. Mol. Cancer Ther. 7 6 (2008) 1569-1578
16. Cordes N., and Park C.C. β1 integrin as a molecular therapeutic target. Int. J. Radiat. Biol. 83 (2007) 753-760