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Volumn 152, Issue 6, 2010, Pages 1033-1042

Citicoline and postconditioning provides neuroprotection in a rat model of ischemic spinal cord injury

Author keywords

Apoptosis; Citicoline; Postconditioning; Spinal cord ischemia

Indexed keywords

BIOLOGICAL MARKER; CASPASE 3; CASPASE 9; CITICOLINE; PROTEIN BAX; PROTEIN BCL 2;

EID: 77953020224     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-010-0598-5     Document Type: Article
Times cited : (15)

References (53)
  • 6
    • 33947179116 scopus 로고    scopus 로고
    • Paraplegia and paraparesis after descending thoracic aortic aneurysm repair: A risk factor analysis
    • Yamauchi T, Takano H, Nishimura M, Matsumiya G, Sawa Y (2006) Paraplegia and paraparesis after descending thoracic aortic aneurysm repair: a risk factor analysis. Ann Thorac Cardiovasc Surg 12:179-183.
    • (2006) Ann Thorac Cardiovasc Surg , vol.12 , pp. 179-183
    • Yamauchi, T.1    Takano, H.2    Nishimura, M.3    Matsumiya, G.4    Sawa, Y.5
  • 7
    • 0028235995 scopus 로고
    • Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries
    • Giglia JS, Zelenock GB, D'Alecy L (1994) Prevention of paraplegia during thoracic aortic cross-clamping: importance of patent internal mammary arteries. J Vasc Surg 19:1044-1051.
    • (1994) J Vasc Surg , vol.19 , pp. 1044-1051
    • Giglia, J.S.1    Zelenock, G.B.2    D'Alecy, L.3
  • 8
    • 0031005857 scopus 로고    scopus 로고
    • Surgery of the thoracic aorta
    • Kouchoukos NT, Dougenis D (1997) Surgery of the thoracic aorta. N Engl J Med 336:1876-1888.
    • (1997) N Engl J Med , vol.336 , pp. 1876-1888
    • Kouchoukos, N.T.1    Dougenis, D.2
  • 11
    • 39649105650 scopus 로고    scopus 로고
    • Co-application of ischemic preconditioning and postconditioning provides additive neuroprotection against spinal cord ischemia in rabbits
    • Jiang X, Shi E, Li L (2008) Co-application of ischemic preconditioning and postconditioning provides additive neuroprotection against spinal cord ischemia in rabbits. Life Sci 82:608-614.
    • (2008) Life Sci , vol.82 , pp. 608-614
    • Jiang, X.1    Shi, E.2    Li, L.3
  • 12
    • 33747503565 scopus 로고    scopus 로고
    • Postconditioning, a series of brief interruptions of early reperfusion, prevents neurologic injury after spinal cord ischemia
    • Jiang X, Shi E, Nakajima Y, Sato S (2006) Postconditioning, a series of brief interruptions of early reperfusion, prevents neurologic injury after spinal cord ischemia. Ann Surg 244:148-153.
    • (2006) Ann Surg , vol.244 , pp. 148-153
    • Jiang, X.1    Shi, E.2    Nakajima, Y.3    Sato, S.4
  • 13
    • 0031440517 scopus 로고    scopus 로고
    • Spinal cord ischemic injury. Development of a new model in the rat
    • Kanellopoulos GK, Kato H, Hsu CY, Kouchoukos NT (1997) Spinal cord ischemic injury. Development of a new model in the rat. Stroke 28:2532-2538.
    • (1997) Stroke , vol.28 , pp. 2532-2538
    • Kanellopoulos, G.K.1    Kato, H.2    Hsu, C.Y.3    Kouchoukos, N.T.4
  • 14
    • 27444443134 scopus 로고    scopus 로고
    • MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats
    • Kocaeli H, Korfali E, Oztürk H, Kahveci N, Yilmazlar S (2005) MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats. Surg Neurol 64(2):22-27.
    • (2005) Surg Neurol , vol.64 , Issue.2 , pp. 22-27
    • Kocaeli, H.1    Korfali, E.2    Oztürk, H.3    Kahveci, N.4    Yilmazlar, S.5
  • 18
    • 0031970954 scopus 로고    scopus 로고
    • Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia
    • Hayashi T, Sakurai M, Abe K, Sadahiro M, Tabayashi K, Itoyama Y (1998) Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke 29:1007-1013. (Pubitemid 28228165)
    • (1998) Stroke , vol.29 , Issue.5 , pp. 1007-1013
    • Hayashi, T.1    Sakurai, M.2    Abe, K.3    Sadahiro, M.4    Tabayashi, K.5    Itoyama, Y.6
  • 20
    • 0025973994 scopus 로고
    • A prospective randomized study of cerebrospinal fluid drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta
    • Crawford ES, Svensson LG, Hess KR (1990) A prospective randomized study of cerebrospinal fluid drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta. J Vasc Surg 13:36-46.
    • (1990) J Vasc Surg , vol.13 , pp. 36-46
    • Crawford, E.S.1    Svensson, L.G.2    Hess, K.R.3
  • 21
    • 0034848373 scopus 로고    scopus 로고
    • Safety and efficacy of hypotermic cardiopulmonary bypass and circulatory arrest for operations on the descending thoracic and thoracoabdominal aorta
    • Kouchoukos NT, Masetti P, Rokkas CK, Murphy SF, Blackstone EH (2001) Safety and efficacy of hypotermic cardiopulmonary bypass and circulatory arrest for operations on the descending thoracic and thoracoabdominal aorta. Ann Thorac Surg 72:699-707.
    • (2001) Ann Thorac Surg , vol.72 , pp. 699-707
    • Kouchoukos, N.T.1    Masetti, P.2    Rokkas, C.K.3    Murphy, S.F.4    Blackstone, E.H.5
  • 22
    • 26244446776 scopus 로고    scopus 로고
    • CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke
    • Adibhatla RM, Hatcher JF, Tureyen K (2005) CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. Brain Res 5:193-197.
    • (2005) Brain Res , vol.5 , pp. 193-197
    • Adibhatla, R.M.1    Hatcher, J.F.2    Tureyen, K.3
  • 23
    • 0035135083 scopus 로고    scopus 로고
    • Pharmacologic neuroprotection in experimental spinal cord ischemia: A systematic review
    • de Haan P, Kalkman CJ, Jacobs MJ (2001) Pharmacologic neuroprotection in experimental spinal cord ischemia: a systematic review. J Neurosurg Anesthesiol 13:3-12.
    • (2001) J Neurosurg Anesthesiol , vol.13 , pp. 3-12
    • De Haan, P.1    Kalkman, C.J.2    Jacobs, M.J.3
  • 24
    • 20144378723 scopus 로고    scopus 로고
    • Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: Effects on glutamate transport
    • Hurtado O, Moro MA, Cardenas A (2005) Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis 18:336-345.
    • (2005) Neurobiol Dis , vol.18 , pp. 336-345
    • Hurtado, O.1    Moro, M.A.2    Cardenas, A.3
  • 25
    • 0036098560 scopus 로고    scopus 로고
    • CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat
    • Krupinski J, Ferrer I, Barrachina M, Secades JJ, Mercadal J, Lozano R (2002) CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology 42:846-854.
    • (2002) Neuropharmacology , vol.42 , pp. 846-854
    • Krupinski, J.1    Ferrer, I.2    Barrachina, M.3    Secades, J.J.4    Mercadal, J.5    Lozano, R.6
  • 26
    • 33750003900 scopus 로고    scopus 로고
    • Citicoline: Pharmacological and clinical review, 2006 update
    • Secades JJ, Lorenzo LJ (2006) Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Pharmacol 27:1-56.
    • (2006) Methods Find Exp Pharmacol , vol.27 , pp. 1-56
    • Secades, J.J.1    Lorenzo, L.J.2
  • 27
    • 37549068147 scopus 로고    scopus 로고
    • Cytidine and üridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release
    • Ulus IH, Watkins CJ, Cansev M (2006) Cytidine and üridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol 26:563-577.
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 563-577
    • Ulus, I.H.1    Watkins, C.J.2    Cansev, M.3
  • 28
    • 0037623908 scopus 로고    scopus 로고
    • Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning
    • Zhao ZQ, Corvera JS, Halkos ME (2003) Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285:579-588.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. 579-588
    • Zhao, Z.Q.1    Corvera, J.S.2    Halkos, M.E.3
  • 29
    • 35648992548 scopus 로고    scopus 로고
    • The protective effect of ischemic postconditioning against ischemic injury: From the heart to the brain
    • Zhao H (2008) The protective effect of ischemic postconditioning against ischemic injury: from the heart to the brain. J Neuroimmune Pharmacol 2:313-318.
    • (2008) J Neuroimmune Pharmacol , vol.2 , pp. 313-318
    • Zhao, H.1
  • 30
    • 28944442996 scopus 로고    scopus 로고
    • Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region
    • Burda J, Matiasova M, Gottlieb M (2005) Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region. Neurochem Res 30:1397-1405.
    • (2005) Neurochem Res , vol.30 , pp. 1397-1405
    • Burda, J.1    Matiasova, M.2    Gottlieb, M.3
  • 31
    • 77953020733 scopus 로고    scopus 로고
    • Neuronal protective effects of focal ischemic pre-and/or postconditioning on 4 the model of transient focal cerebral ischemia in rats
    • Taskapilioglu MO, Alkan T, Goren B, Tureyen K, Sahin S, Taskapilioglu O, Korfali E (2008) Neuronal protective effects of focal ischemic pre-and/or postconditioning on 4 the model of transient focal cerebral ischemia in rats. J Clin Neurosci 1010-1016.
    • (2008) J Clin Neurosci , pp. 1010-1016
    • Taskapilioglu, M.O.1    Alkan, T.2    Goren, B.3    Tureyen, K.4    Sahin, S.5    Taskapilioglu, O.6    Korfali, E.7
  • 32
    • 33747603205 scopus 로고    scopus 로고
    • Interrupting reperfusion as a stroke theraphy: Ischemic postconditioning reduces infarct size after focal ischemia in ras
    • Zhao H, Sapolsky RM, Steinberg GK (2006) Interrupting reperfusion as a stroke theraphy: ischemic postconditioning reduces infarct size after focal ischemia in ras. J Cereb Blood Flow Metab 26:1114-1122.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1114-1122
    • Zhao, H.1    Sapolsky, R.M.2    Steinberg, G.K.3
  • 33
    • 0023200806 scopus 로고
    • Paraplegia in the rat induced by aortic cross-clamping: Model characterization and glucose exacerbation of neurologic deficit
    • LeMay DR, Neal S, Neal S, Zelenock GB, D'Alecy LG (1987) Paraplegia in the rat induced by aortic cross-clamping: model characterization and glucose exacerbation of neurologic deficit. J Vasc Surg 6:383-390.
    • (1987) J Vasc Surg , vol.6 , pp. 383-390
    • LeMay, D.R.1    Neal, S.2    Neal, S.3    Zelenock, G.B.4    D'Alecy, L.G.5
  • 34
    • 0034662011 scopus 로고    scopus 로고
    • Advances in secondary spinal cord injury
    • Lu J, Ken WSA, Waite P (2000) Advances in secondary spinal cord injury. Spine 25:1859-1866.
    • (2000) Spine , vol.25 , pp. 1859-1866
    • Lu, J.1    Ken, W.S.A.2    Waite, P.3
  • 35
    • 0019942376 scopus 로고
    • Spectrum of neurological deficits in experimental CNS ischemia: A quantitative study
    • Zivin JA, DeGirolami U, Hurwitz EL (1982) Spectrum of neurological deficits in experimental CNS ischemia: a quantitative study. Arch Neurol 39:408-412.
    • (1982) Arch Neurol , vol.39 , pp. 408-412
    • Zivin, J.A.1    Degirolami, U.2    Hurwitz, E.L.3
  • 36
    • 0035041217 scopus 로고    scopus 로고
    • The effects of FK506 on neurological and histopathologic outcome after transient spinal cord ischemia induced by aortic crossclamping in rats
    • Lang-Lazdunski L, Heurteaux C, Dupont H, Rouelle D, Widmann C, Mantz J (2001) The effects of FK506 on neurological and histopathologic outcome after transient spinal cord ischemia induced by aortic crossclamping in rats. Anesth Analg 92:1237-1244.
    • (2001) Anesth Analg , vol.92 , pp. 1237-1244
    • Lang-Lazdunski, L.1    Heurteaux, C.2    Dupont, H.3    Rouelle, D.4    Widmann, C.5    Mantz, J.6
  • 37
    • 31344432053 scopus 로고    scopus 로고
    • Phospholipase A2, reactive oxygen species and lipid peroxidation in cerebral ischemia
    • Adibhatla RM, Hatcher JF (2006) Phospholipase A2, reactive oxygen species and lipid peroxidation in cerebral ischemia. Free Radic Biol Med 40:376-387.
    • (2006) Free Radic Biol Med , vol.40 , pp. 376-387
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 38
    • 0037248032 scopus 로고    scopus 로고
    • Perspectives on reperfusioninduced damage in rodent models of experimental focal ischemia and role of protein kinase C
    • Aronowski J, Labiche LA (2003) Perspectives on reperfusioninduced damage in rodent models of experimental focal ischemia and role of protein kinase C. ILAR 44:105-109.
    • (2003) ILAR , vol.44 , pp. 105-109
    • Aronowski, J.1    Labiche, L.A.2
  • 39
    • 0030856804 scopus 로고    scopus 로고
    • Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats
    • Aronowski J, Strong R, Grotta JC (1997) Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab 17:1048-1056.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 1048-1056
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 40
    • 34547565191 scopus 로고    scopus 로고
    • Tissue plasminogen activatorinduced reperfusion injury after stroke revisited
    • Hermann DM, Matter CM (2007) Tissue plasminogen activatorinduced reperfusion injury after stroke revisited. Circulation 116:363-365.
    • (2007) Circulation , vol.116 , pp. 363-365
    • Hermann, D.M.1    Matter, C.M.2
  • 42
  • 43
    • 0036163730 scopus 로고    scopus 로고
    • Cerebral blood flow restoration and reperfusion injury after ultraviolet laser-facilitated middle cerebral artery recanalization in rat thrombotic stroke
    • Watson BD, Prado R, Veloso A, Brunschwig JP, Dietrich WD (2002) Cerebral blood flow restoration and reperfusion injury after ultraviolet laser-facilitated middle cerebral artery recanalization in rat thrombotic stroke. Stroke 33:428-434.
    • (2002) Stroke , vol.33 , pp. 428-434
    • Watson, B.D.1    Prado, R.2    Veloso, A.3    Brunschwig, J.P.4    Dietrich, W.D.5
  • 44
    • 21644471753 scopus 로고    scopus 로고
    • Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition
    • Danielisová V, Némethová M, Gottlieb M, Burda J (2005) Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition. Neurochem Res 30:559-565.
    • (2005) Neurochem Res , vol.30 , pp. 559-565
    • Danielisová, V.1    Némethová, M.2    Gottlieb, M.3    Burda, J.4
  • 45
    • 4043060632 scopus 로고    scopus 로고
    • Postconditioning: A form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway
    • Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM (2004) Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 95:230-232.
    • (2004) Circ Res , vol.95 , pp. 230-232
    • Tsang, A.1    Hausenloy, D.J.2    Mocanu, M.M.3    Yellon, D.M.4
  • 46
    • 49849103054 scopus 로고    scopus 로고
    • Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat
    • Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X, Zhang S (2008) Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke 39:2362-2369.
    • (2008) Stroke , vol.39 , pp. 2362-2369
    • Xing, B.1    Chen, H.2    Zhang, M.3    Zhao, D.4    Jiang, R.5    Liu, X.6    Zhang, S.7
  • 47
    • 0036270432 scopus 로고    scopus 로고
    • Citicoline: Neuroprotective mechanism in cerebral ischemia
    • Adibhatla RM, Hatcher JF, Dempsey RJ (2002) Citicoline: neuroprotective mechanism in cerebral ischemia. J Neurochem 80:12-23.
    • (2002) J Neurochem , vol.80 , pp. 12-23
    • Adibhatla, R.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 48
    • 33646596630 scopus 로고    scopus 로고
    • CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: Phosphocholine cytidylyltransferase after stroke
    • Adibhatla RM, Hatcher JF, Larsen EC, Chen X, Sun D, Tsao FH (2006) CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. J Biol Chem 281:6718-6725.
    • (2006) J Biol Chem , vol.281 , pp. 6718-6725
    • Adibhatla, R.M.1    Hatcher, J.F.2    Larsen, E.C.3    Chen, X.4    Sun, D.5    Tsao, F.H.6
  • 51
    • 33746355252 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: Improved behavioral and neuroanatomical recovery
    • Yücel N, Cayli SR, Ateş O (2006) Evaluation of the neuroprotective effects of citicoline after experimental spinal cord injury: improved behavioral and neuroanatomical recovery. Neurochem Res 31:767-775.
    • (2006) Neurochem Res , vol.31 , pp. 767-775
    • Yücel, N.1    Cayli, S.R.2    Ateş, O.3
  • 52
    • 0342545881 scopus 로고    scopus 로고
    • Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury
    • Başkaya MK, Dogan A, Rao AM, Dempsey RJ (2000) Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg 92:448-452.
    • (2000) J Neurosurg , vol.92 , pp. 448-452
    • Başkaya, M.K.1    Dogan, A.2    Rao, A.M.3    Dempsey, R.J.4
  • 53
    • 0037238367 scopus 로고    scopus 로고
    • Caspase activation in neuronal and glial apoptosis following spinal cord injury in mice
    • Takagi T, Takayasu M, Mizuno M, Yoshimoto M, Yoshida J (2003) Caspase activation in neuronal and glial apoptosis following spinal cord injury in mice. Neurol Med Chir 43:20-30.
    • (2003) Neurol Med Chir , vol.43 , pp. 20-30
    • Takagi, T.1    Takayasu, M.2    Mizuno, M.3    Yoshimoto, M.4    Yoshida, J.5


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