The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development

Developmental Biology

Volumn 342, Issue 2, 2010, Pages 146-156

  Risley, Michael D ^a   Clowes, Christopher ^a   Yu, Ming ^a   Mitchell, Karen ^a   Hentges, Kathryn E ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cdc2; Col2a1; Growth; Limb bud; Med31; Mediator complex; Mouse mutagenesis; Proliferation; Sox9; Transcription

Indexed keywords

CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 2; MEDIATOR COMPLEX PROTEIN 31; PROTEIN COL2A1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FIBROBLAST; FORELIMB; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIMB BUD; MAMMAL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

MAMMALIA;

EID: 77953020027     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2010.03.019     Document Type: Article

References (41)

1. Akiyama H., C.M., Martin J.F., Schedl A., de Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002, 16:2813-2828.
2. Barrionuevo F., N.A., Bagheri-Fam S., Speth V., Taketo M.M., Scherer G., Neubüser A. Sox9 is required for invagination of the otic placode in mice. Dev Biol. 2008, 317:213-224.
3. Beyer K.S., Beauchamp R.L., Lee M.F., Gusella J.F., Naar A.M., Ramesh V. Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. J. Biol. Chem. 2007, 282:32152-32157.
4. Bi W., Huang W., Whitworth D.J., Deng J.M., Zhang Z., Behringer R.R., de Crombrugghe B. Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:6698-6703.
5. Blazek E., Mittler G., Meisterernst M. The mediator of RNA polymerase II. Chromosoma 2005, 113:399-408.
6. Bosveld F., van Hoek S., Sibon O.C. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional mediator subunit dMED31. Dev. Biol. 2008, 313:802-813.
7. Brodsky D., Christou H. Current concepts in intrauterine growth restriction. J. Intensive Care Med. 2004, 19:307-319.
8. Budirahardja Y., Gonczy P. Coupling the cell cycle to development. Development 2009, 136:2861-2872.
9. Chen W., Roeder R.G. The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res. 2007, 35:6161-6169.
10. Efstratiadis A. Genetics of mouse growth. Int. J. Dev. Biol. 1998, 42:955-976.
11. Fan H.Y., Klein H.L. Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae. Genetics 1994, 137:945-956.
12. Fan H.Y., Cheng K.K., Klein H.L. Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae. Genetics 1996, 142:749-759.
13. Fernández-Terán M.A., H.J., Ros M.A. Birth and death of cells in limb development: a mapping study. Dev. Dyn. 2006, 235:2521-2537.
14. Ge K., Cho Y.W., Guo H., Hong T.B., Guermah M., Ito M., Yu H., Kalkum M., Roeder R.G. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol. Cell. Biol. 2008, 28:1081-1091.
15. Gersch R.P., Hadjiargyrou M. Mustn1 is expressed during chondrogenesis and is necessary for chondrocyte proliferation and differentiation in vitro. Bone 2009, 45:330-338.
16. Gordon D.F., Tucker E.A., Tundwal K., Hall H., Wood W.M., Ridgway E.C. MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes. Mol. Endocrinol. 2006, 20:1073-1089.
17. Grallert A., Grallert B., Zilahi E., Szilagyi Z., Sipiczki M. Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation. Yeast 1999, 15:669-686.
18. Guglielmi B., van Berkum N.L., Klapholz B., Bijma T., Boube M., Boschiero C., Bourbon H.M., Holstege F.C., Werner M. A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res. 2004, 32:5379-5391.
19. Han V.K., Carter A.M. Control of growth and development of the feto-placental unit. Curr. Opin. Pharmacol. 2001, 1:632-640.
20. Henrique D., A.J., Myat A., Chitnis A., Lewis J., Ish-Horowicz D. Expression of a Delta homologue in prospective neurons in the chick. Nature 1995, 375:787-790.
21. Hentges K.E., Sirry B., Gingeras A.C., Sarbassov D., Sonenberg N., Sabatini D., Peterson A.S. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:13796-13801.
22. Hentges K.E., Nakamura H., Furuta Y., Yu Y., Thompson D.M., O'Brien W., Bradley A., Justice M.J. Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr. Patterns 2006, 6:653-665.
23. Ito M., Yuan C.X., Okano H.J., Darnell R.B., Roeder R.G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell 2000, 5:683-693.
24. Ito M., Okano H.J., Darnell R.B., Roeder R.G. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J. 2002, 21:3464-3475.
25. Kile B.T., Hentges K.E., Clark A.T., Nakamura H., Salinger A.P., Liu B., Box N., Stockton D.W., Johnson R.L., Behringer R.R., Bradley A., Justice M.J. Functional genetic analysis of mouse chromosome 11. Nature 2003, 425:81-86.
26. Koschubs T., Seizl M., Lariviere L., Kurth F., Baumli S., Martin D.E., Cramer P. Identification, structure, and functional requirement of the Mediator submodule Med7N/31. EMBO J. 2009, 28:69-80.
27. Lefebvre V., Li P., de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998, 17:5718-5733.
28. Lewandoski M., S.X., Martin G.R. Fgf8 signalling from the AER is essential for normal limb development. Nat. Genet. 2000, 26:460-463.
29. Linder T., Gustafsson C.M. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae mediator. J. Biol. Chem. 2004, 279:49455-49459.
30. Malik S., Roeder R.G. Dynamic regulation of Pol II transcription by the mammalian Mediator complex. Trends Biochem. Sci. 2005, 30:256-263.
31. Nakayama K., Nagahama H., Minamishima Y.A., Miyake S., Ishida N., Hatakeyama S., Kitagawa M., Iemura S., Natsume T., Nakayama K.I. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev. Cell 2004, 6:661-672.
32. Rau M.J., Fischer S., Neumann C.J. Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Dev. Biol. 2006, 296:83-93.
33. Rokutanda S., Fujita T., Kanatani N., Yoshida C.A., Komori H., Liu W., Mizuno A., Komori T. Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev. Biol. 2009, 328:78-93.
34. Santamaria D., Barriere C., Cerqueira A., Hunt S., Tardy C., Newton K., Caceres J.F., Dubus P., Malumbres M., Barbacid M. Cdk1 is sufficient to drive the mammalian cell cycle. Nature 2007, 448:811-815.
35. Shimizu H., Y.S., Asahara H. Growth and differentiation of the developing limb bud from the perspective of chondrogenesis. Dev. Growth Differ. 2007, 49:449-454.
36. Stumpf M., Waskow C., Krotschel M., van Essen D., Rodriguez P., Zhang X., Guyot B., Roeder R.G., Borggrefe T. The Mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:18504-18509.
37. Tschop K., Engeland K. Cell cycle-dependent transcription of cyclin B2 is influenced by DNA methylation but is independent of methylation in the CDE and CHR elements. FEBS J. 2007, 274:5235-5249.
38. Welch J.J., W.J., Vakoc C.R., Yao Y., Wang H., Hardison R.C., Blobel G.A., Chodosh L.A., Weiss M.J. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 2004, 104:3136-3147.
39. Yuan C.X., Ito M., Fondell J.D., Fu Z.Y., Roeder R.G. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:7939-7944.
40. Zhang J., Fondell J.D. Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. Mol. Endocrinol. 1999, 13:1130-1140.
41. Zhu Y., Qi C., Jain S., Rao M.S., Reddy J.K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J. Biol. Chem. 1997, 272:25500-25506.