Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients

Genes, Brain and Behavior

Volumn 9, Issue 4, 2010, Pages 411-418

  Magno, L A V ^a,b   Miranda, D M ^a,b,c   Neves, F S ^a   Pimenta, G J ^a,b   Mello, M P ^a,b   De Marco, L A ^a,b   Correa, H ^a,b   Romano Silva, M A ^a,b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INCT de Medicina Molecular ^*  (Brazil)

^c FUNDAÇÃO HOSPITALAR DO ESTADO DE MINAS GERAIS   (Brazil)

Author keywords

AKT1; AKTIP; Bipolar disorder; Suicidal behavior; Violent suicide attempts

Indexed keywords

ADULT; AKT1 GENE; AKTIP GENE; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; VIOLENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; APOPTOSIS REGULATORY PROTEINS; BIPOLAR DISORDER; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-AKT; SUICIDE; SUICIDE, ATTEMPTED;

EID: 77952978458     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2010.00571.x     Document Type: Article

References (44)

1. Amorim, P. (2000) Mini International Neuropsychiatric Interview (MINI): validation of a short structured diagnostic psychiatric interview. Rev Bras Psiquiatr 22, 106 115.
2. Asberg, M., Traskman, L. Thoren, P. (1976) 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 33, 1193 1197.
3. Baldessarini, R.J., Tondo, L., Davis, P., Pompili, M., Goodwin, F.K. Hennen, J. (2006) Decreased suicidal risk during long-term lithium treatment: a meta-analysis. Bipolar Disord 8, 625 639.
4. Barrett, J.C., Fry, B., Maller, J. Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 15, 263 265.
5. Beaulieu, J.M., Gainetdinov, R.R. Caron, M.G. (2007a) The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci 28, 166 172.
6. Beaulieu, J.M., Tirotta, E., Sotnikova, T.D., Masri, B., Salahpour, A., Gainetdinov, R., Borrelli, E. Caron, M.G. (2007b) Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci 27, 881 885.
7. Beaulieu, J.M., Marion, S., Rodriguiz, R.M., Medvedev, I.O., Sotnikova, T.D., Ghisi, V., Wetsel, W.C., Lefkowitz, R.J., Gainetdinov, R.R. Caron, M.G. (2008) A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 11, 125 136.
8. Bondy, B., Buettner, A. Zill, P. (2006) Genetics of suicide. Mol Psychiatry 11, 336 351.
9. Brent, D.A., Oquendo, M., Birmaher, B., Greenhill, L., Kolko, D., Stanley, B., Zelazny J., Brodsky, B., Bridge, J., Ellis, S., Salazar, J.O. Mann, J.J. (2002) Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Arch Gen Psychiatry 59, 801 807.
10. Chen, Y.W. Dilsaver, S.C. (1996) Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biol Psychiatry 39, 896 899
11. Coccaro, E.F., Siever, L.J., Klar, H.M., Maurer, G., Cochrane, K., Cooper, T.B., Mohs, R.C. Davis, K.L. (1989) Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 46, 587 599.
12. Comtois, K.A., Russo, J.E., Roy-Byrne, P. Ries, R.K. (2004) Clinicians' assessments of bipolar disorder and substance abuse as predictors of suicidal behavior in acutely hospitalized psychiatric inpatients. Biol Psychiatry 56, 757 763.
13. Corrêa, H., Duval, F., Mokrani, M.C., Bailey, P., Trémeau, F., Staner, L., Diep, T.S., Crocq, M.A. Macher, J.P. (2002) Serotonergic function and suicidal behavior in schizophrenia. Schizophr Res 56, 75 85.
14. Dudbridge, F. (2008) Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 66, 87 98.
15. Dunning, A.M., Durocher, F., Healey, C.S., Teare, M.D., McBride, S.E., Carlomagno, F., Xu, C.F., Dawson, E., Rhodes, S., Ueda, S., Lai, E., Luben, R.N., Van Rensburg, E.J., Mannermaa, A., Kataja, V., Rennart, G., Dunham, I., Purvis, I., Easton, D. Ponder, B.A. (2000) The extent of linkage disequilibrium in four populations with distinct demographic histories. Am J Hum Genet 67, 1544 1554.
16. Einat, H. Manji, H.K. (2006) Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. Biol Psychiatry 59, 1160 1171.
17. Engstrom, C., Brandstrom, S., Sigvardsson, S., Cloninger, C.R. Nylander, P.O. (2004) Bipolar disorder III: harm avoidance a risk factor for suicide attempts. Bipolar Disord 6, 130 138.
18. Fiedorowicz, J.G., Leon, A.C., Keller, M.B., Solomon, D.A., Rice, J.P. Coryell, W.H. (2008) Do risk factors for suicidal behavior differ by affective disorder polarity? Psychol Med 30, 1 9
19. Grunebaum, M.F., Oquendo, M.A., Harkavy-Friedman, J.M., Ellis, S.P., Li, S., Haas, G.L., Malone, K.M. Mann, J.J. (2001) Delusions and suicidality. Am J Psychiatry 158, 742 747
20. Grunebaum, M.F., Ramsay, S.R., Galfalvy, H.C., Ellis, S.P., Burke, A.K., Sher, L., Printz, D.J., Kahn, D.A., Mann, J.J. Oquendo, M.A. (2006) Correlates of suicide attempt history in bipolar disorder: a stress-diathesis perspective. Bipolar Disord 8, 551 557.
21. Guo, S. (2004) Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav 3, 63 74
22. Hill, W.G., Goddard, M.E. Visscher, P.M. (2008) Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet 4, e1000008.
23. Hsiung, S.C., Adlersberg, M., Arango, V., Mann, J.J., Tamir, H. Liu, K.P. (2003) Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. J Neurochem 87, 182 194
24. Isometsa, E.T. Lonnqvist, J.K. (1998) Suicide attempts preceding completed suicide. Br J Psychiatry 173, 531 535
25. Karege, F., Perroud, N., Burkhardt, S., Schwald, M., Ballmann, E., La Harpe, R. Malafosse, A. (2007) Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3 beta in ventral prefrontal cortex of depressed suicide victims. Biol Psychiatry 61, 240 245.
26. Kawa, I., Carter, J.D., Joyce, P.R., Doughty, C.J., Frampton, C.M., Wells, J.E., Walsh, A.E.S. Olds, R.J. (2005) Gender differences in bipolar disorder: age of onset, course, comorbidity, and symptom presentation. Bipolar Disord 7, 119 125.
27. Kessler, R.C., Borges, G. Walters, E.E. (1999) Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey. Arch Gen Psychiatry 56, 617 626.
28. Lahiri, D.K. Nurnberger, J.I., Jr. (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 11, 5444.
29. Malloy-Diniz, L.F., Neves, F.S., Abrantes, S.S.C., Fuentes, D. Correa, H. (2009) Suicide behavior and neuropsychological assessment of type I bipolar patients. J Affect Disord 12, 231 236.
30. Mann, J.J. (2002) A current perspective of suicide and attempted suicide. Ann Intern Med 136, 302 311.
31. Moore, J.H. (2004) Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn 4, 795 803.
32. Motsinger, A.A. Ritchie, M.D. (2006) Multifactor dimensionality reduction: an analysis strategy for modeling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics 2, 318 328.
33. Neves, F.S., Silveira, G., Romano-Silva, M.A., Malloy-Diniz, L., Ferreira, A.A., De Marco, L.A. Correa, H. (2008) Is the 5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients? Am J Med Genet B Neuropsychiatr Genet 147B, 114 116.
34. Neves, F.S., Malloy-Diniz, L.F. Corrêa, H. (2009) Suicidal behavior in bipolar disorder: what is the influence of psychiatric comorbidities? J Clin Psychiatry 70, 13 18.
35. Pompili, M., Innamorati, M., Raja, M., Falcone, I., Ducci, G., Angeletti, G., Lester, D., Girardi, P., Tatarelli, R. De Pisa, E. (2008) Suicide risk in depression and bipolar disorder: do impulsiveness-aggressiveness and pharmacotherapy predict suicidal intent? Neuropsychiatr Dis Treat 4, 247 255.
36. Potash, J.B., Kane, H.S., Chiu, Y.F., Simpson, S.G., MacKinnon, D.F., McInnis, M.G., McMahon, F.J. De Paulo, J.R., Jr. (2000) Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships. Am J Psychiatry 157, 2048 2050.
37. Remy, I. Michnick, S.W. (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol Cell Biol 24, 1493 1504.
38. Sale, E.M. Sale, G.J. (2008) Protein kinase B: signaling roles and therapeutic targeting. Cell Mol Life Sci 65, 113 127.
39. Sher, L., Mann, J.J., Traskman-Bendz, L., Winchel, R., Huang, Y.Y., Fertuck, E. Stanley, B.H. (2006) Lower cerebrospinal fluid homovanillic acid levels in depressed suicide attempters. J Affect Disord 190, 83 89.
40. Souza, R.P., Romano-Silva, M.A., Lieberman, J.A., Meltzer, H.Y., Wong, A.H. Kennedy, J.L. (2008) Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response. Psychopharmacology (Berl) 200, 177 186.
41. Terwilliger, J.D., Zollner, S., Laan, M. Paabo, S. (1998) Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'drift mapping' in small populations with no demographic expansion. Hum Hered 48, 138 154.
42. Tsuang, M.T., Taylor, L. Faraone, S.V. (2004) An overview of the genetics of psychotic mood disorders. J Psychiatr Res 38, 47 61.
43. Viana, M.M., De Marco, L.A., Boson, W.L., Romano-Silva, M.A. Corrêa, H. (2006) Investigation of A218C tryptophan hydroxylase polymorphism: association with familial suicide behavior and proband's suicide attempt characteristics. Genes Brain Behav 5, 340 345.
44. Wasserman, D., Sokolowski, M., Rozanov, V. Wasserman, J. (2008) The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress. Genes Brain Behav 7, 14 19