Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response

Psychopharmacology

Volumn 200, Issue 2, 2008, Pages 177-186

  Souza, Renan P ^a,b   Romano Silva, Marco A ^a   Lieberman, Jeffrey A ^d   Meltzer, Herbert Y ^e   Wong, Albert H C ^b   Kennedy, James L ^b,c  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

Clozapine response; Family based association test; Genetic association; GSK3 ; Schizophrenia; Wnt signaling

Indexed keywords

CLOZAPINE; GLYCOGEN SYNTHASE KINASE 3BETA;

ADULT; ARTICLE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SCHIZOPHRENIA; TREATMENT RESPONSE;

ADULT; ALLELES; ANTIPSYCHOTIC AGENTS; CASE-CONTROL STUDIES; CLOZAPINE; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLYCOGEN SYNTHASE KINASE 3; HAPLOTYPES; HUMANS; MALE; POLYMORPHISM, GENETIC; SCHIZOPHRENIA;

EID: 51249097728     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1193-9     Document Type: Article

References (64)

1. M Aickin 1999 Other method for adjustment of multiple testing exists BMJ 318 127 128
2. H Alimohamad N Rajakumar YH Seah W Rushlow 2005 Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum Biol Psychiatry 57 533 542
3. H Alimohamad L Sutton J Mouyal N Rajakumar WJ Rushlow 2005 The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats J Neurochem 95 513 525
4. J Ananth S Parameswaran S Gunatilake 2004 Side effects of atypical antipsychotic drugs Curr Pharm Des 10 2219 2229
5. DJ Balding 2006 A tutorial on statistical methods for population association studies Nat Rev Genet 7 781 791
6. JC Barrett B Fry J Maller MJ Daly 2005 Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 263 265
7. VS Basile M Masellis SG Potkin JL Kennedy 2002 Pharmacogenomics in schizophrenia: the quest for individualized therapy Hum Mol Genet 11 2517 2530
8. C Beasley D Cotter N Khan C Pollard P Sheppard I Varndell S Lovestone B Anderton I Everall 2001 Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia Neurosci Lett 302 117 120
9. JM Beaulieu TD Sotnikova S Marion RJ Lefkowitz RR Gainetdinov MG Caron 2005 An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior Cell 122 261 273
10. JM Beaulieu TD Sotnikova WD Yao L Kockeritz JR Woodgett RR Gainetdinov MG Caron 2004 Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade Proc Natl Acad Sci U S A 101 5099 5104
11. JM Beaulieu E Tirotta TD Sotnikova B Masri A Salahpour RR Gainetdinov E Borrelli MG Caron 2007 Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo J Neurosci 27 881 885
12. R Bender S Lange 1999 Multiple test procedures other than Bonferroni's deserve wider use BMJ 318 600 601
13. D Cotter R Kerwin S Al-Sarraji JP Brion A Chadwich S Lovestone B Anderton I Everall 1998 Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality Neuroreport 9 1379 1383
14. F Dudbridge 2003 Pedigree disequilibrium tests for multilocus haplotypes Genet Epidemiol 25 115 121
15. C Durrant KT Zondervan LR Cardon S Hunt P Deloukas AP Morris 2004 Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes Am J Hum Genet 75 35 43
16. ES Emamian D Hall MJ Birnbaum M Karayiorgou JA Gogos 2004 Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia Nat Genet 36 131 137
17. JN Feder A Gnirke W Thomas Z Tsuchihashi DA Ruddy A Basava F Dormishian R Domingo Jr MC Ellis A Fullan LM Hinton NL Jones BE Kimmel GS Kronmal P Lauer VK Lee DB Loeb FA Mapa E McClelland NC Meyer GA Mintier N Moeller T Moore E Morikang CE Prass L Quintana SM Starnes RC Schatzman KJ Brunke DT Drayna NJ Risch BR Bacon RK Wolff 1996 A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat Genet 13 399 408
18. SB Gabriel SF Schaffner H Nguyen JM Moore J Roy B Blumenstiel J Higgins M DeFelice A Lochner M Faggart SN Liu-Cordero C Rotimi A Adeyemo R Cooper R Ward ES Lander MJ Daly D Altshuler 2002 The structure of haplotype blocks in the human genome Science 296 2225 2229
19. SW Guo EA Thompson 1992 Performing the exact test of Hardy-Weinberg proportion for multiple alleles Biometrics 48 361 372
20. K Hao X Xu N Laird X Wang X Xu 2004 Power estimation of multiple SNP association test of case-control study and application Genet Epidemiol 26 22 30
21. J Hoh A Wille J Ott 2001 Trimming, weighting, and grouping SNPs in human case-control association studies Genome Res 11 2115 2119
22. R Hwang T Shinkai LV De DJ Muller X Ni F Macciardi S Potkin JA Lieberman HY Meltzer JL Kennedy 2005 Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations Psychopharmacology (Berl) 181 179 187
23. M Ikeda N Iwata T Suzuki T Kitajima Y Yamanouchi Y Kinoshita N Ozaki 2005 No association of GSK3beta gene (GSK3B) with Japanese schizophrenia Am J Med Genet B Neuropsychiatr Genet 134 90 92
24. RS Jope GV Johnson 2004 The glamour and gloom of glycogen synthase kinase-3 Trends Biochem Sci 29 95 102
25. RS Jope MS Roh 2006 Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions Curr Drug Targets 7 1421 1434
26. RS Jope CJ Yuskaitis E Beurel 2007 Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics Neurochem Res 32 577 595
27. J Kane G Honigfeld J Singer H Meltzer 1988 Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine Arch Gen Psychiatry 45 789 796
28. UG Kang MS Seo MS Roh Y Kim SC Yoon YS Kim 2004 The effects of clozapine on the GSK-3-mediated signaling pathway FEBS Lett 560 115 119
29. S Kapur P Seeman 2001 Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: a new hypothesis Am J Psychiatry 158 360 369
30. N Kozlovsky S Amar RH Belmaker G Agam 2006 Psychotropic drugs affect Ser9-phosphorylated GSK-3 beta protein levels in rodent frontal cortex Int J Neuropsychopharmacol 9 337 342
31. N Kozlovsky RH Belmaker G Agam 2000 Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients Am J Psychiatry 157 831 833
32. N Kozlovsky RH Belmaker G Agam 2001 Low GSK-3 activity in frontal cortex of schizophrenic patients Schizophr Res 52 101 105
33. N Kozlovsky C Shanon-Weickert E Tomaskovic-Crook JE Kleinman RH Belmaker G Agam 2004 Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients J Neural Transm 111 1583 1592
34. DK Lahiri JI Nurnberger 1991 A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acids Res 19 5444
35. NM Laird S Horvath X Xu 2000 Implementing a unified approach to family-based tests of association Genet Epidemiol 19 Suppl 1 S36 S42
36. WC Lee 2003 Searching for disease-susceptibility loci by testing for Hardy-Weinberg disequilibrium in a gene bank of affected individuals Am J Epidemiol 158 397 400
37. KY Lee YM Ahn EJ Joo SH Jeong JS Chang SC Kim YS Kim 2006 No association of two common SNPs at position -1727 A/T, -50 C/T of GSK-3 beta polymorphisms with schizophrenia and bipolar disorder of Korean population Neurosci Lett 395 175 178
38. X Li W Zhu MS Roh AB Friedman K Rosborough RS Jope 2004 In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain Neuropsychopharmacology 29 1426 1431
39. X Li KM Rosborough AB Friedman W Zhu KA Roth 2007 Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics Int J Neuropsychopharmacol 10 7 19
40. X Luo HR Kranzler L Zuo J Lappalainen BZ Yang J Gelernter 2006 ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies Neuropsychopharmacology 31 1085 1095
41. X Luo HR Kranzler L Zuo S Wang HP Blumberg J Gelernter 2005 CHRM2 gene predisposes to alcohol, drug dependence and affective disorder: results from an extended population structured association study Hum Mol Genet 14 2421 2434
42. AK Malhotra RE Litman D Pickar 1993 Adverse effects of antipsychotic drugs Drug Saf 9 429 436
43. AK Malhotra GM Murphy JL Kennedy 2004 Pharmacogenetics of psychotropic drug response Am J Psychiatry 161 780 796
44. HY Meltzer 1989 Clinical studies in the mechanism of action of clozapine: the dopamine serotonin hypothesis of schizophrenia Psychopharmacology 99 518 527
45. C Nadri BK Lipska N Kozlovsky DR Weinberger RH Belmaker G Agam 2003 Glycogen synthase kinase (GSK)-3beta levels and activity in a neurodevelopmental rat model of schizophrenia Brain Res Dev Brain Res 141 33 37
46. C Nadri B Dean E Scarr G Agam 2004 GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients Schizophr Res 71 377 382
47. DM Nielsen MG Ehm BS Weir 1998 Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus Am J Hum Genet 63 1531 1540
48. DR Nyholt 2004 A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other Am J Hum Genet 74 765 769
49. TV Perneger 1998 What's wrong with Bonferroni adjustments BMJ 316 1236 1238
50. S Purcell SS Cherny PC Sham 2003 Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits Bioinformatics 19 149 150
51. MS Roh MS Seo Y Kim SH Kim WJ Jeon YM Ahn UG Kang YS Juhnn YS Kim 2007 Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex Exp Mol Med 39 353 360
52. C Scassellati C Bonvicini J Perez L Bocchio-Chiavetto GB Tura G Rossi G Racagni M Gennarelli 2004 Association study of -1727 A/T, -50 C/T and (CAA)n repeat GSK-3beta gene polymorphisms with schizophrenia Neuropsychobiology 50 16 20
53. P Seeman 2002 Atypical antipsychotics: mechanism of action Can J Psychiatry 47 27 38
54. P Seeman T Lee 1975 Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons Science 188 1217 1219
55. SY Shin SC Yoon YH Kim YS Kim YH Lee 2002 Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts Exp Mol Med 34 444 450
56. C Sutherland IA Leighton P Cohen 1993 Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling Biochem J 296 Pt 1 15 19
57. P Svenningsson ET Tzavara R Carruthers I Rachleff S Wattler M Nehls DL McKinzie AA Fienberg GG Nomikos P Greengard 2003 Diverse psychotomimetics act through a common signaling pathway Science 302 1412 1415
58. A Szczepankiewicz M Skibinska J Hauser A Slopien A Leszczynska-Rodziewicz P Kapelski M Dmitrzak-Weglarz PM Czerski JK Rybakowski 2006 Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder Neuropsychobiology 53 51 56
59. TA Trikalinos G Salanti MJ Khoury JP Ioannidis 2006 Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations Am J Epidemiol 163 300 309
60. JE Wigginton GR Abecasis 2005 PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data Bioinformatics 21 3445 3447
61. JE Wigginton DJ Cutler GR Abecasis 2005 A note on exact tests of Hardy-Weinberg equilibrium Am J Hum Genet 76 887 893
62. JK Wittke-Thompson A Pluzhnikov NJ Cox 2005 Rational inferences about departures from Hardy-Weinberg equilibrium Am J Hum Genet 76 967 986
63. JR Woodgett 1990 Molecular cloning and expression of glycogen synthase kinase-3/factor A EMBO J 9 2431 2438
64. SD Yang JS Yu TT Lee CC Yang MH Ni YY Yang 1995 Dysfunction of protein kinase FA/GSK-3 alpha in lymphocytes of patients with schizophrenic disorder J Cell Biochem 59 108 116