Human tissue-specific microenvironment: An essential requirement for mouse models of breast cancer

Oncology Reports

Volumn 24, Issue 1, 2010, Pages 203-211

  Xia, Tian Song ^a   Wang, Jue ^a   Yin, Hong ^a   Ding, Qiang ^a   Zhang, Yi Fen ^b   Yang, Hai Wei ^a   Liu, Xiao An ^a   Dong, Min ^c   Du, Qing ^a   Ling, Li Jun ^a   Zha, Xiao Ming ^a   Fu, Wei ^a   Wang, Shui ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c Jiangsu Provincial Tumor Hospital   (China)

Author keywords

Breast cancer; Human microenvironment; Metastasis; Mouse model; Orthotope; Xenograft

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE TISSUE; BONE TRANSPLANTATION; BREAST CANCER; CANCELLOUS BONE; CANCER CELL CULTURE; CANCER MODEL; CARCINOGENICITY; CELL LABELING; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INOCULATION; LUNG PARENCHYMA; MESENTERY; MICROENVIRONMENT; MICROSCOPY; MOUSE; NONHUMAN; ORGAN GROWTH; PRIORITY JOURNAL; RELIABILITY; SCID MOUSE; TISSUE SPECIFICITY; ANIMAL; ANTIBODY SPECIFICITY; BONE TUMOR; BREAST TUMOR; CANCER TRANSPLANTATION; CARCINOMA; EVALUATION STUDY; EXPERIMENTAL MAMMARY NEOPLASM; HETEROTOPIC TRANSPLANTATION; MAMMARY GLAND; METASTASIS; PATHOLOGY; SECONDARY; SPECIES DIFFERENCE; TUMOR CELL CULTURE; XENOGRAFT;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CARCINOMA; FEMALE; HUMANS; MAMMARY GLANDS, HUMAN; MAMMARY NEOPLASMS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, SCID; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; SPECIES SPECIFICITY; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HETEROTOPIC; TUMOR CELLS, CULTURED;

EID: 77952967795     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000847     Document Type: Article

References (32)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
2. Sharpless NE and Depinho RA: The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5: 741-754, 2006. (Pubitemid 44323701)
3. Kelland LR: Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur J Cancer 40: 827-836, 2004.
4. Kamb A: What's wrong with our cancer models? Nat Rev Drug Discov 4: 161-165, 2005.
5. Kung AL: Practices and pitfalls of mouse cancer models in drug discovery. Adv Cancer Res 96: 191-212, 2007.
6. Kerbel RS: Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved. Cancer Biol Ther 2: 134-139, 2003.
7. Sausville EA and Burger AM: Contributions of human tumor xenografts to anticancer drug development. Cancer Res 66: 3351-3354, 2006.
8. Hoffman RM: Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy. Methods Mol Med 111: 297-322, 2005.
9. Inaba M, Tashiro T, Kobayashi T, et al: Responsiveness of human gastric tumors implanted in nude mice to clinically equivalent doses of various antitumor agents. Jpn J Cancer Res 79: 517-522, 1988.
10. Wang J, Xia TS, Liu XA, et al: A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment. Breast Cancer Res Treat 120: 337-344, 2010.
11. Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572, 2002. (Pubitemid 37328923)
12. Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
13. Yoneda T, Williams PJ, Hiraga T, Niewolna M and Nishimura R: A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res 16: 1486-1495, 2001. (Pubitemid 32675200)
14. Garcia T, Jackson A, Bachelier R, et al: A convenient clinically relevant model of human breast cancer bone metastasis. Clin Exp Metastasis 25: 33-42, 2008. (Pubitemid 351191224)
15. Laidlaw IJ, Clarke RB, Howell A, Owen AW, Potten CS and Anderson E: The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. Endocrinology 136: 164-171, 1995.
16. Nemeth JA, Harb JF, Barroso U Jr, He Z, Grignon DJ and Cher ML: Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res 59: 1987-1993, 1999.
17. Yonou H, Yokose T, Kamijo T, et al: Establishment of a novel species- and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immuno-deficient mice engrafted with human adult lung and bone. Cancer Res 61: 2177-2182, 2001. (Pubitemid 32692044)
18. Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2: 584-593, 2002.
19. Cailleau R, Young R, Olivé M and Reeves WJ Jr: Breast tumor cell lines from pleural effusions. J Natl Cancer Inst 53: 661-674, 1974.
20. Pratap J, Wixted JJ, Gaur T, et al: Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res 68: 7795-7802, 2008.
21. Neudert M, Fischer C, Krempien B, Seibel MJ and Bauss F: A rapid histological score for the semiquantitative assessment of bone metastases in experimental models of breast cancer. Onkologie 31: 521-527, 2008.
22. Miner KM, Kawaguchi T, Uba GW and Nicolson GL: Clonal drift of cell surface, melanogenic, and experimental metastatic properties of in vivo-selected, brain meninges-colonizing murine B16 melanoma. Cancer Res 42: 4631-4638, 1982. (Pubitemid 13205967)
23. Gotzmann J, Mikula M, Eger A, et al: Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis. Mutat Res 566: 9-20, 2004. (Pubitemid 38045586)
24. Nicolson GL, Belloni PN, Tressler RJ, Dulski K, Inoue T and Cavanaugh PG: Adhesive, invasive, and growth properties of selected metastatic variants of a murine large-cell lymphoma. Invasion Metastasis 9: 102-116, 1989. (Pubitemid 19075672)
25. Minn AJ, Kang Y, Serganova I, et al: Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest 115: 44-55, 2005. (Pubitemid 40385504)
26. Gilbey AM, Burnett D, Coleman RE and Holen I: The detection of circulating breast cancer cells in blood. J Clin Pathol 57: 903-911, 2004. (Pubitemid 39208239)
27. Riethdorf S and Pantel K: Disseminated tumor cells in bone marrow and circulating tumor cells in blood of breast cancer patients: current state of detection and characterization. Pathobiology 75: 140-148, 2008. (Pubitemid 351820732)
28. Ottewell PD, Coleman RE and Holen I: From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies. Breast Cancer Res Treat 96: 101-113, 2006.
29. Ottewell PD, Deux B, Mönkkönen H, et al: Differential effect of doxorubicin and zoledronic acid on intraosseous versus extra-osseous breast tumor growth in vivo. Clin Cancer Res 14: 4658-4666, 2008.
30. Winding B, Misander H, Høegh-Andersen P, Brünner N and Foged NT: Estradiol enhances osteolytic lesions in mice inoculated with human estrogen receptor-negative MDA-231 breast cancer cells in vivo. Breast Cancer Res Treat 78: 205-216, 2003. (Pubitemid 36433913)
31. Kuperwasser C, Dessain S, Bierbaum BE, et al: A mouse model of human breast cancer metastasis to human bone. Cancer Res 65: 6130-6138, 2005. (Pubitemid 40994398)
32. Yang W, Lam P, Kitching R, et al: Breast cancer metastasis in a human bone NOD/SCID mouse model. Cancer Biol Ther 6: 1289-1294, 2007. (Pubitemid 351590385)