A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment

Breast Cancer Research and Treatment

Volumn 120, Issue 2, 2010, Pages 337-344

  Wang, Jue ^a   Xia, Tian Song ^a   Liu, Xiao An ^a   Ding, Qiang ^a   Du, Qing ^a   Yin, Hong ^b   Wang, Shui ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

BOM model; In vivo model; Metastasis breast cancer; Orthotope; Xenograft

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL; CANCER MODEL; CANCER TRANSPLANTATION; CELL PROLIFERATION; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; CELL LINE, TUMOR; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; TRANSFECTION;

EID: 77950689392     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0391-4     Document Type: Article

References (33)

1. Jemal A, Siegel R, Ward E et al (2008) Cancer statistics, 2008. CA Cancer J Clin 58:71-96. doi:10.3322/CA.2007.0010
2. 2. Chambers AF, Groom AC, MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572, doi: 10.1038/nrc865 (Pubitemid 37328923)
3. Fidler IJ (2003) The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3:453-458. doi: 10.1038/nrc1098
4. 4. Kim JB, Stein R, O'Hare MJ (2005) Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis. Tumour Biol 26:173-185. doi: 10.1159/000086950 (Pubitemid 41379743)
5. Bhowmick. NA, Moses HL (2005) Tumor-stroma interactions. Cure Opin Genet Dev 15:97-101. doi:10.1016/j.gde.2004.12.003
6. 6. Finak G, Bertos N, Pepin F et al (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14:518-527. doi:10.1038/nm1764 (Pubitemid 351655218)
7. Sleeman. JP, Cremers N (2007) New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment. Clin Exp Metastasis 24:707-715. doi:.1.0.1.007/s10585-007-9122-9126
8. Ottewell PD, Coleman RE, Holen I (2006) From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies. Breast Cancer Res Treat 96:101-113. doi:10.1007/s10549- 005-9067-x
9. 9. Arguello F, Baggs RB, Frantz CN (1988) A murine model of experimental metastasis to bone and bone marrow. Cancer Res 48:6876-6881 (Pubitemid 19012221)
10. 10. Minn AJ, Kang Y, Serganova I et al (2005) Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest 115:44-55 (Pubitemid 40385504)
11. 11. Miner KM, Kawaguchi T, Uba GW et al (1982) Clonal drift of cell surface, melanogenic, and experimental metastatic properties of in vivo-selected, brain meninges-colonizing murine B16 melanoma. Cancer Res 42:4631-4638 (Pubitemid 13205967)
12. Daoud SS, Leathers CW, Hurst JM (2002) p53 expression, growth, and spontaneous metastasis of the human GI 101 breast carcinoma in athymic nude mice. J Exp Ther Oncol 2:121-127. doi:10.1046/j.1359-4117.2002.01018x
13. 13. Sypniewska RK, Hoflack L, Tarango M et al (2005) Prevention of metastases with a Mage-b DNA vaccine in a mouse breast tumor model: potential for breast cancer therapy. Breast Cancer Res Treat 91:19-28. doi: 10.1007/s10549-004-6454-7 (Pubitemid 40684935)
14. Fu X, Le P, Hoffman RM ( 1.993) A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. Anticancer Res 13:901-904
15. Laidlaw IJ, Clarke RB, Howell A et al (1995) The proliferation of normal human breast tissue implanted into athymic nude mice is stimulated by estrogen but not progesterone. Endocrinology 136:164-171. doi: 10.1210/en.136.1.164
16. 16. Kaplan RN, Riba RD, Zacharoulis S et al (2005) VEGFR1positive haematopoietic bone marrow progenitors initiate the premetastatic niche. Nature 438:820-827. doi: 10.1038/nature04186 (Pubitemid 41753060)
17. 17. Rønnov-Jessen L, Petersen OW, Bissell MJ (1996) Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 76:69-125 (Pubitemid 26048279)
18. Liotta LA, Kohn EC (2001) The microenvironment of the tumourhost interface. Nature 411:375-379. doi: 10.1038/35077241.
19. Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev Cancer 1:46-54. doi: 10.1038/35094059
20. Mueller MM, Fusenig NE (2004) Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4:839-849. doi: 10.1038/nrc1477
21. 21. Howe JR, Roth S, Ringold JC et al ( 1998) Mutations in the SMAD4/ DPC4 gene in juvenile polyposis. Science 280:1086-1088. doi: 10.1126/science.280.5366.1086 (Pubitemid 28234951)
22. Hoffman RM (1999) Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs 17:343-359. doi:10.1023/A:1006326203858
23. 23. Stingl J, Caldas C (2007) Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 7:791-799. doi:10.1038/nrc2212 (Pubitemid 47463670)
24. Perou CM, Sørlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747-752, doi: 10.1038/35021093
25. 25. Sørlie T, Perou CM, Tibshirani R et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874. doi:10.1073/pnas.191367098 (Pubitemid 32878711)
26. 26. Sorlie T, Tibshirani R, Parker J et al (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 100:8418-8423. doi:10.1073/pnas. 0932692100 (Pubitemid 36842560)
27. 27. Sotiriou C, Neo SY, McShane LM et al (2003) Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci USA 100: 10393-10398. doi: 10.1073/pnas. 1732912100 (Pubitemid 37071889)
28. Polyak K (2007) Breast cancer: origins and evolution. J Clin Invest 117:3155-3163. doi: 10.1172/JCI33295
29. 29. Segditsas S, Tomlinson I (2006) Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 25:7531-7537. doi: 10.1038/sj.onc. 1210059 (Pubitemid 44885752)
30. Naumov GN, MacDonald IC, Weinmeister PM et al (2002) Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. Cancer Res 62:2162-2168
31. 31. Neve RM, Chin K, Fridlyand J et al (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10:515-527. doi:10.1016/j.ccr.2006.10.008 (Pubitemid 44854747)
32. Minn AJ, Gupta GP, Siegel PM et al (2005) Genes that mediate breast cancer metastasis to lung. Nature 436:518-524. doi: 10.1038/ nature03799
33. 33. Kang Y, Siegel PM, Shu W et al (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 3:537549. doi : 10.1016/S1535-6108(03)00132-6 (Pubitemid 36808649)