A rapid histological score for the semiquantitative assessment of bone metastases in experimental models of breast cancer

Onkologie

Volumn 31, Issue 10, 2008, Pages 521-527

  Neudert, Marcus ^a,b   Fischer, Christian ^a   Krempien, Burkhard ^a   Seibel, Markus J ^a,c   Bauss, Frieder ^d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF SYDNEY   (Australia)

^d ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Bisphosphonates; Bone metastases; Histology; Score; Tumor osteolysis

Indexed keywords

IBANDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BREAST CANCER; COMPUTER ANALYSIS; CONTROLLED STUDY; DISEASE MODEL; DRUG MECHANISM; HISTOPATHOLOGY; MALE; NONHUMAN; OSTEOLYSIS; QUANTITATIVE ANALYSIS; RAT; SCORING SYSTEM; TIBIA; WHOLE BODY IMAGING;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; RATS; RATS, NUDE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 53949088266     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151622     Document Type: Article

References (11)

1. Coleman RE, Rubens RD: Bone metastases and breast cancer. Cancer Treat Rev 1985;12:251-270.
2. Coleman RE, Rubens RD: The clinical course of bone metastases from breast cancer. Br J Cancer 1987;55:61-66.
3. Theriault RL, Hortobagyi GN: Bone metastasis in breast cancer. Anticancer Drugs 1992;3:455-462.
4. Russell RG: Bisphosphonates: from bench to bedside. Ann NY Acad Sci 2006;1068:367-401.
5. Krempien B, Wingen F, Eichmann T, Mueller M, Schmahl D: Protective effects of a prophylactic treatment with the bisphosphonate 3-amino-1- hydroxypropane-1.1-bisphosphonic acid on the development of tumor osteopathies in the rat: experimental studies with the Walker carcinosarcoma 256. Oncology 1988;45:41-46.
6. Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T: Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 1995;55:3551-3557.
7. Kurth AA, Muller R: The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model. Skeletal Radiol 2001;30:94-98.
8. Neudert M, Fischer C, Krempien B, Bauss F, Seibel MJ: Site-specific human breast cancer (MDA-MB-231) metastases in nude rats: model characterisation and in vivo effects of ibandronate on tumour growth. Int J Cancer 2003;107:468-477.
9. Cailleau R, Young R, Olive M, Reeves WJ Jr: Breast tumor cell lines from pleural effusions. J Natl Cancer Inst 1974;53:661-674.
10. Juraschek M, Seibel MJ, Woitge HW, Krempien B, Bauss F: Association between histomorphometry and biochemical markers of bone turnover in a longitudinal rat model of PTHrP-mediated tumor osteolysis. Bone 2000;26:475-483.
11. Orr W: Tumor-bone interaction in skeletal metastases. Clin Orthop 1995;312:19-33.