Sex Differences in the Effects of Inherited Bitter Thiourea Sensitivity on Body Weight in 4-6-Year-Old Children

Obesity

Volumn 18, Issue 6, 2010, Pages 1194-1200

  Keller, Kathleen L ^a   Reid, Adrienne ^a   MacDougall, Megan C ^a   Cassano, Hope ^a   Song, Joo Lee ^a   Deng, Liyong ^a   Lanzano, Patricia ^a   Chung, Wendy K ^a   Kissileff, Harry R ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLTHIOUREA; PROPYLTHIOURACIL; THIOUREA; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ALLELE; ARTICLE; BITTER TASTE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FAT INTAKE; FEMALE; GENE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHENOTYPE; PREDICTION; PRESCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TAS2R38 GENE; TASTE ACUITY; UNITED STATES; GENETIC DISORDER; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; OBESITY; PHYSIOLOGY; RISK; SEXUAL DEVELOPMENT; TASTE; TASTE DISORDER; COMPLICATION; GENETIC DISEASES, INBORN; TASTE DISORDERS;

BODY MASS INDEX; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; OBESITY; PROPYLTHIOURACIL; RECEPTORS, G-PROTEIN-COUPLED; RISK; SEX CHARACTERISTICS; TASTE; TASTE DISORDERS; THIOUREA;

EID: 77952956809     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.306     Document Type: Article

References (50)

1. Bartoshuk LM, Duffy VB, Miller IJ,. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav 1994; 56: 1165-1171.
2. Fox AL,. The Relationship between Chemical Constitution and Taste. Proc Natl Acad Sci USA 1932; 18: 115-120.
3. Tepper BJ,. 6-n-Propylthiouracil: a genetic marker for taste, with implications for food preference and dietary habits. Am J Hum Genet 1998; 63: 1271-1276.
4. Tepper BJ,. Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes. Annu Rev Nutr 2008; 28: 367-388.
5. Essick GK, Chopra A, Guest S, McGlone F,. Lingual tactile acuity, taste perception, and the density and diameter of fungiform papillae in female subjects. Physiol Behav 2003; 80: 289-302.
6. Glanville EV, and, Kaplan AR,. Food preferences and sensitivity of taste for bitter compounds. Nature 1965; 205: 851-852.
7. Duffy VB, Lucchina LA, Bartoshuk LM,. Genetic variation in taste: potential biomarker for cardiovascular disease? In:, Prescott J, Tepper BJ, (eds). Genetic Variation in Taste Sensitivity. Marcel Dekker: New York, 2004, pp 195-228.
8. Goldstein GL, Daun H, Tepper BJ,. Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil. Obes Res 2005; 13: 1017-1023.
9. Keller KL, Tepper BJ,. Inherited taste sensitivity to 6-n-propylthiouracil in diet and body weight in children. Obes Res 2004; 12: 904-912.
10. Tepper BJ, Ullrich NV,. Influence of genetic taste sensitivity to 6-n-propylthiouracil (PROP), dietary restraint and disinhibition on body mass index in middle-aged women. Physiol Behav 2002; 75: 305-312.
11. Drewnowski A, Henderson SA, Hann CS, Berg WA, Ruffin MT,. Genetic taste markers and preferences for vegetables and fruit of female breast cancer patients. J Am Diet Assoc 2000; 100: 191-197.
12. Drewnowski A, Kristal A, Cohen J,. Genetic taste responses to 6-n-propylthiouracil among adults: a screening tool for epidemiological studies. Chem Senses 2001; 26: 483-489.
13. Drewnowski A, Henderson SA, Cockroft JE,. Genetic sensitivity to 6-n-propylthiouracil has no influence on dietary patterns, body mass indexes, or plasma lipid profiles of women. J Am Diet Assoc 2007; 107: 1340-1348.
14. Lumeng JC, Cardinal TM, Sitto JR, Kannan S,. Ability to taste 6-n-propylthiouracil and BMI in low-income preschool-aged children. Obesity (Silver Spring) 2008; 16: 1522-1528.
15. Fischer R, Griffin F, Rockey MA,. Gustatory chemoreception in man: multidisciplinary aspects and perspectives. Perspect Biol Med 1966; 9: 549-577.
16. Prutkin J, Fisher EM, Etter L, et al., Genetic variation and inferences about perceived taste intensity in mice and men. Physiol Behav 2000; 69: 161-173.
17. Duffy VB,. Perceived creaminess of high-fat milk products varies with genetic taste status. Chem Senses 1996; 21: 598. (abstr.)
18. Tepper BJ, Nurse RJ,. Fat perception is related to PROP taster status. Physiol Behav 1997; 61: 949-954.
19. Hayes JE, Duffy VB,. Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation. Chem Senses 2007; 32: 225-236.
20. Duffy VB, Bartoshuk LM,. Food acceptance and genetic variation in taste. J Am Diet Assoc 2000; 100: 647-655.
21. Keller KL, Steinmann L, Nurse RJ, Tepper BJ,. Genetic taste sensitivity to 6-n-propylthiouracil influences food preference and reported intake in preschool children. Appetite 2002; 38: 3-12.
22. Tepper BJ, Nurse RJ,. PROP taster status is related to fat perception and preference. Ann N Y Acad Sci 1998; 855: 802-804.
23. Hayes JE, Duffy VB,. Oral sensory phenotype identifies level of sugar and fat required for maximal liking. Physiol Behav 2008; 95: 77-87.
24. Lissner L, and, Heitmann BL,. Dietary fat and obesity: evidence from epidemiology. Eur.J Clin Nutr 1995; 49: 79-90.
25. Anliker JA, Bartoshuk L, Ferris AM, Hooks LD,. Children's food preferences and genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP). Am J Clin Nutr 1991; 54: 316-320.
26. Yackinous CA, Guinard JX,. Relation between PROP (6-n-propylthiouracil) taster status, taste anatomy and dietary intake measures for young men and women. Appetite 2002; 38: 201-209.
27. Yackinous C, Guinard JX,. Relation between PROP taster status and fat perception, touch, and olfaction. Physiol Behav 2001; 72: 427-437.
28. Kim UK, Jorgenson E, Coon H, et al., Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003; 299: 1221-1225.
29. Bufe B, Breslin PA, Kuhn C, et al., The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005; 15: 322-327.
30. Mennella JA, Pepino MY, Reed DR,. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005; 115: e216-e222.
31. Sacerdote C, Guarrera S, Smith GD, et al., Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer risk. Am J Epidemiol 2007; 166: 576-581.
32. Timpson NJ, Heron J, Day IN, et al., Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. BMC Genet 2007; 8: 51.
33. Cowart BJ,. Development of taste perception in humans: sensitivity and preference throughout the lifespan. Psychol Bull 1981; 90: 43-73.
34. Cole TJ, Bellizi MC, Flegal KM, and, Dietz WH,. Establishing a standard definition for child overweight adn obesity worldwide: International survey. Br Med Journal 2000; 320: 1-6.
35. Birch LL, Fisher JO, Grimm-Thomas K, et al., Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness. Appetite 2001; 36: 201-210.
36. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al., CDC growth charts: United States. Adv Data 2000;(314): 1-27.
37. Faith MS, Keller KL, Johnson SL, et al., Familial aggregation of energy intake in children. Am J Clin Nutr 2004; 79: 844-850.
38. Goldstein GL, Daun H, Tepper BJ,. Influence of PROP taster status and maternal variables on energy intake and body weight of pre-adolescents. Physiol Behav 2007; 90: 809-817.
39. Cutting TM, Fisher JO, Grimm-Thomas K, Birch LL,. Like mother, like daughter: familial patterns of overweight are mediated by mothers' dietary disinhibition. Am J Clin Nutr 1999; 69: 608-613.
40. van den Bree MB, Eaves LJ, Dwyer JT,. Genetic and environmental influences on eating patterns of twins aged >/=50 y. Am J Clin Nutr 1999; 70: 456-465.
41. de Castro JM,. Genes and environment have gender-independent influences on the eating and drinking of free-living humans. Physiol Behav 1998; 63: 385-395.
42. de Castro JM,. A twin study of genetic and environmental influences on the intake of fluids and beverages. Physiol Behav 1993; 54: 677-687.
43. Faith MS, Rhea SA, Corley RP, Hewitt JK,. Genetic and shared environmental influences on children's 24-h food and beverage intake: sex differences at age 7 y. Am J Clin Nutr 2008; 87: 903-911.
44. Barnicot NA, Harris H, Kalmus H,. Taste thresholds of further eighteen compounds and their correlation with P.T.C thresholds. Ann Eugen 1951; 16: 119-128.
45. Tepper BJ, Koelliker Y, Zhao L, et al., Variation in the bitter-taste receptor gene TAS2R38, and adiposity in a genetically isolated population in Southern Italy. Obesity (Silver Spring) 2008; 16: 2289-2295.
46. Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB,. Supertasting and PROP bitterness depends on more than the TAS2R38 gene. Chem Senses 2008; 33: 255-265.
47. Birch LL, Johnson SL, Andresen G, Peters JC, Schulte MC,. The variability of young children's energy intake. N Engl J Med 1991; 324: 232-235.
48. Goran MI,. Metabolic precursors and effects of obesity in children: a decade of progress, 1990-1999. Am J Clin Nutr 2001; 73: 58-71.
49. Ziegler P, Briefel R, Ponza M, Novak T, and, Hendricks K,. Nutrient intakes and food patterns of toddlers' lunches and snacks: influence of location. J Am Diet Assoc 2006; 106: S124-S134.
50. Fisher JO, Birch LL,. Restricting access to palatable foods affects children's behavioral response, food selection, and intake. Am J Clin Nutr 1999; 69: 1264-1272.