Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression

Obesity

Volumn 18, Issue 6, 2010, Pages 1218-1225

  Schleinitz, Dorit ^a   Klöting, Nora ^b   Körner, Antje ^a   Berndt, Janin ^a   Reichenbächer, Marlene ^b   Tönjes, Anke ^b   Ruschke, Karen ^b   Böttcher, Yvonne ^b   Dietrich, Kerstin ^a   Enigk, Beate ^a   Filz, Matthias ^b   Schön, Michael R ^c   Jenkner, Jost ^c   Kiess, Wieland ^a   Stumvoll, Michael ^b   Blüher, Matthias ^b   Kovacs, Peter ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c STÄDTISCHES KLINIKUM KARLSRUHE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; GLUCOSE; INSULIN; MESSENGER RNA;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; FASN GENE; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GERMANY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; INSULIN BLOOD LEVEL; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; SCHOOL CHILD; SEQUENCE ANALYSIS; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST HIP RATIO; ADIPOSE TISSUE; ADOLESCENT; AGED; ANTIBODY SPECIFICITY; CASE CONTROL STUDY; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; VERY ELDERLY; YOUNG ADULT;

ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; FATTY ACID SYNTHASES; FEMALE; GENE EXPRESSION; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; OBESITY; ORGAN SPECIFICITY; RNA, MESSENGER; YOUNG ADULT; FATTY ACID SYNTHETASE COMPLEX;

MUS;

EID: 77952955019     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2009.392     Document Type: Article

References (30)

1. Must A, Spadano J, Coakley EH, et al., The disease burden associated with overweight and obesity. JAMA 1999; 282: 1523-1529.
2. Aarsland A, Chinkes D, Wolfe RR,. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia hyperinsulinemia in normal man. J Clin Invest 1996; 98: 2008-2017.
3. Semenkovich CF,. Regulation of fatty acid synthase (FAS). Prog Lipid Res 1997; 36: 43-53.
4. Loftus TM, Jaworsky DE, Frehywot GL, et al., Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 2379-2381.
5. Thupari JN, Kim EK, Moran TH, Ronnett GV, Kuhajda FP,. Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am J Physiol Endocrinol Metab 2004; 287: E97-E104.
6. Mobbs CV, Makimura H,. Block the FAS, lose the fat. Nat Med 2002; 8: 335-336.
7. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP,. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 2002; 99: 9498-9502.
8. Norman RA, Tataranni PA, Pratley R, et al., Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 1998; 62: 659-668.
9. Lillioja S, Mott DM, Spraul M, et al., Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993; 329: 1988-1992.
10. Knowler WC, Bennett PH, Hamman RF, Miller M,. Diabetes incidence and prevalence in Pima Indians: a 19-fold greater incidence than in Rochester, Minnesota. Am J Epidemiol 1978; 108: 497-505.
11. Kovacs P, Harper I, Hanson RL, et al., A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Diabetes 2004; 53: 1915-1919.
12. Körner A, Ma L, Franks PW, et al., Sex-specific effect of the Val1483Ile polymorphism in the fatty acid synthase gene (FAS) on body mass index and lipid profile in Caucasian children. Int J Obes (Lond) 2007; 31: 353-358.
13. Berndt J, Kovacs P, Ruschke K, et al., Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 2007; 50: 1472-1480.
14. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006; 29: S43-S48.
15. Blüher M, Unger R, Rassoul F, Richter V, Paschke R,. Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes. Diabetologia 2002; 45: 210-216.
16. Defronzo RA, Tobin JD, Andres R,. Glucose Clamp Technique-Method for Quantifying Insulin-Secretion and Resistance. Am J Physiol 1979; 237: E214-E223.
17. Reich A, Müller G, Gelbrich G, Deutscher K, Gödicke R, Kiess W,. Obesity and blood pressure-results from the examination of 2365 schoolchildren in Germany. Int J Obes Relat Metab Disord 2003; 27: 1459-1464.
18. Kromeyer-Hauschild K, et al., Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001; 149: 807-818.
19. Böttner A, Kratzsch J, Müller G, et al., Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004; 89: 4053-4061.
20. Stephens M, Smith NJ, Donnelly P,. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978-989.
21. Stephens M, Donnelly P,. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162-1169.
22. de Bakker PI, Yelensky R, Pe'er I, et al., Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217-1223.
23. Emilsson V, Thorleifsson G, Zhang B, et al., Genetics of gene expression and its effect on disease. Nature 2008; 452: 423-428.
24. Chirala SS, Jayakumar A, Gu ZW, Wakil SJ,. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Proc Natl Acad Sci USA 2001; 98: 3104-3108.
25. Moreno-Navarrete JM, Botas P, Valdes S, et al., Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult Caucasian men. Obesity 2009; e-pub ahead of print 19 March 2009.
26. Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD,. Gender differences in plasma leptin concentrations. Nat Med 1996; 2: 949-950.
27. Mattevi VS, Zembrzuski VM, Hutz MH,. A resistin gene polymorphism is associated with body mass index in women. Hum Genet 2004; 115: 208-212.
28. Ridderstråle M, Carlsson E, Klannemark M, et al., FOXC2 mRNA Expression and a 5′ untranslated region polymorphism of the gene are associated with insulin resistance. Diabetes 2002; 51: 3554-3560.
29. Ma L, Tataranni PA, Hanson RL, et al., Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Diabetes 2005; 54: 1598-1602.
30. Tönjes A, Zeggini E, Kovacs P, et al., Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet 2009; e-pub ahead of print 8 july 2009.