Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells

Toxicology in Vitro

Volumn 24, Issue 4, 2010, Pages 1092-1097

  Li, Ji ^a   Zhang, Liang ^b,c   Jiang, Zhenzhou ^a   Shu, Bin ^a,d   Li, Fu ^a   Bao, Qingli ^a   Zhang, Luyong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c Jiangsu Province Key Lab of Efficiency and Safety Evaluation of Chinese Medicine   (China)

^d NANJING TECH UNIVERSITY   (China)

Author keywords

Aristolochic acid I (AA I); Aristololactam I (AL I); Cytotoxicity; Human proximal tubular epithelial cell lines (HK 2 cells)

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARISTOLOCHIC ACID; ARISTOLOCHIC ACID I; ARISTOLOLACTAM; ARISTOLOLACTAM I; CASPASE 3; LIPOCORTIN 5; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CELL; KIDNEY EPITHELIUM; PROTEIN EXPRESSION; TOXICITY TESTING;

APOPTOSIS; ARISTOLOCHIC ACIDS; CASPASE 3; CELL LINE; CYTOTOXINS; EPITHELIAL CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL;

EID: 77952954871     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.03.012     Document Type: Article

References (15)

1. Chang H.R., Lian J.D., Lo C.W., Chang Y.C., Yang M.Y., Wang C.J. Induction of urothelial proliferation in rats by aristolochic acid through cell cycle progression via activation of cyclin D1/cdk4 and cyclin E/cdk2. Food Chem. Toxicol. 2006, 44:28-35.
2. Debelle F.D., Nortier J.L., De Prez E.G., Garbar C.H., Vienne A.R., Salmon I.J., Deschodt-Lanckman M.M., Vanherweghem J.L. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J. Am. Soc. Nephrol. 2002, 13:431-436.
3. Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., Henson P.M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 1992, 148:2207-2216.
4. Ito A., Uehara T., Tokumitsu A., Okuma Y., Nomura Y. Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells. Biochim. Biophys. Acta 1999, 1452:263-274.
5. Jackson L., Kofman S., Weiss A., Brodovsky H. Aristolochic acid (Nsc-50413): phase I clinical study. Cancer Chemoth. Rep. 1964, 42:35-37.
6. Li Y., Liu Z., Guo X., Shu J., Chen Z., Li L. Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro. Arch. Toxicol. 2006, 80:524-532.
7. Ling Z., Jiang Z.Z., Huang X., Zhang L.Y., Xu X.Y. A liquid chromatography-mass spectrometry method for the quantitation of aristololactam-I in rat plasma. Biomed. Chromatogr. 2007, 21:10-14.
8. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trend. Biochem. Sci. 1997, 22:299-306.
9. Shang P., Wang X., Li X.M., Tang J.W., Cai S.Q. Observation of penetration, distribution and accumulation in human renal proximal tubular epithelial cells by aristololactam-I. Zhongguo Zhong yao za zhi=Zhongguo zhongyao zazhi=China J. Chinese Mater. Med. 2008, 33:793-797.
10. Vanherweghem J.L., Abramowicz D., Tielemans C., Depierreux M. Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy. Am. J. Kidney Dis. 1996, 27:209-215.
11. Vanherweghem J.L., Depierreux M., Tielemans C., Abramowicz D., Dratwa M., Jadoul M., Richard C., Vandervelde D., Verbeelen D., Vanhaelen-Fastre R., et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993, 341:387-391.
12. Wilson M.R. Apoptotic signal transduction: emerging pathways. Biochemistry and Cell Biology=Biochim. Biol. Cell. 1998, 76:573-582.
13. Yuan J., Luo X., Guo M., Wu J., Yang W., Yu R., Yao S. Determination of aristolochic acid I and its metabolites in cell culture with a hyphenated high-performance liquid chromatographic technique for cell toxicology. Talanta 2009, 78:1141-1147.
14. Zamai L., Falcieri E., Marhefka G., Vitale M. Supravital exposure to propidium iodide identifies apoptotic cells in the absence of nucleosomal DNA fragmentation. Cytometry 1996, 23:303-311.
15. Zhang C., Wang X., Shang M., Yu J., Xu Y., Li Z., Lei L., Li X., Cai S., Namba T. Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high-performance liquid chromatography. Biomed. Chromatogr. 2006, 20:309-318.