A liquid chromatography-mass spectrometry method for the quantitation of aristololactam-I in rat plasma

Biomedical Chromatography

Volumn 21, Issue 1, 2007, Pages 10-14

  Ling, Zhen ^a   Jiang, Zhen Zhou ^a   Huang, Xin ^a   Zhang, Lu Yong ^a   Xu, Xiao Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aristolochic acid I; Aristololactam I; LC MS; Rat plasma; Toxicokinetics

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS;

ARISTOLOCHIC ACID; ARISTOLOCHIC ACID-I; ARISTOLOLACTAM-I; LC-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; ORAL ADMINISTRATION; RAT PLASMA; SENSITIVE METHOD; TOXICOKINETICS;

QUALITY CONTROL;

ACETIC ACID; ARISTOLOCHIC ACID; ARISTOLOLACTAM; FINASTERIDE; METHANOL; WATER;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUALITY CONTROL; RAT; SAMPLE; SENSITIVITY AND SPECIFICITY; TOXICOKINETICS;

RATTUS;

EID: 33846497963     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.707     Document Type: Article

References (4)

1. Krumbiegel G, Hallensleben J, Mennicke WH and Rittmann N. Studies on the metabolism of aristolochic acids I and II. Xenobitotica 1987; 17(8): 981-991.
2. Li B, Li X, Zhang C-Y, Wang X and Cai S-q. Cellular mechanism of renal proximal tubular epithelial cell injury induced by aristolochic acid-I and AL-I. Journal of Peking University (Health Sciences) 2004; 36: 36-40.
3. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R et al. Rapidly progressive intersititial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-391.
4. Van Ypersele de Strihou C and Vanherweghem JL. The tragic paradigm of Chinese herb's nephropathy. Nephrology, Dialysis and Transplantation 1995; 10: 157-160.