Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6420-6432

  Meng, Charles Q ^a   Somers, Patricia K ^a   Hoong, Lee K ^a   Zheng, X Sharon ^a   Ye, Zhihong ^a   Worsencroft, Kimberly J ^a   Simpson, Jacob E ^a   Hotema, Martha R ^a   Weingarten, M David ^a   MacDonald, Mathew L ^a   Hill, Russell R ^a   Marino, Elaine M ^a   Suen, Ki Ling ^a   Luchoomun, Jayraz ^a   Kunsch, Charles ^a   Landers, Laura K ^a   Stefanopoulos, Dimitria ^a   Howard, Randy B ^a   Sundell, Cynthia L ^a   Saxena, Uday ^a   Wasserman, Martin A ^a   Sikorski, James A ^a   more..

^a AtheroGenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2,6 DI TERT BUTYL 4 [1 (3,5 DI TERT BUTYL 4 HYDROXYPHENYLSULFANYL) 1 METHYLETHYLSULFANYL]PHENOXY]BUTANE 1,2,3 TRIOL; 4 [4 [[1 [[3,5 BIS(1,1 DIMETHYLETHYL) 4 HYDROXYPHENYL]THIO] 1 METHYLETHYL]THIO] 2,6 BIS(1,1 DIMETHYLETHYL)PHENOXY]BUTANOIC ACID; 6 O [2,6 DI TERT BUTYL 4 [1 (3,5 DI TERT BUTYL 4 HYDROXYPHENYLSULFANYL) 1 METHYLETHYLSULFANYL]PHENYL] DEXTRO GLUCITOL; 6 O [2,6 DI TERT BUTYL 4 [1 (3,5 DI TERT BUTYL 4 HYDROXYPHENYLSULFANYL) 1 METHYLETHYLSULFANYL]PHENYL] DEXTRO GLUCOPYRANOSE; [4 [[1 [[3,5 BIS(1,1, DIMETHYLETHYL) 4 HYDROXYPHENYL]THIO] 1 METHYLETHYL]THIO] 2,6 BIS(1,1 DIMETHYLETHYL)PHENOXY]ACETIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYTOKINE; ETHER DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PHENOL DERIVATIVE; PROBUCOL; PROTEIN SYNTHESIS INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1 INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ASSAY; CHRONIC GRAFT REJECTION; CHRONIC INFLAMMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKOCYTE MIGRATION INHIBITION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATION REDUCTION REACTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYRIAN HAMSTER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CELLS, CULTURED; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHRONIC DISEASE; CRICETINAE; DEPRESSION, CHEMICAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; PHENOLS; PROBUCOL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 9744237246     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049685u     Document Type: Article

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