VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: Implications for inflammatory bowel disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 4, 2006, Pages

  Goebel, Stephen ^a   Huang, Meng ^a   Davis, William C ^a   Jennings, Merilyn ^a   Siahaan, Teruna J ^b   Steven Alexander, J ^a   Kevil, Christopher G ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Angiogenesis; CD18; Colitis; Inflammation; Integrin; Vascular endothelial growth factor

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CELLULAR DISTRIBUTION; COLITIS; CONTROLLED STUDY; ENDOTHELIUM CELL; HYDRODYNAMICS; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INFLAMMATION; LEUKOCYTE ADHERENCE; LEUKOCYTE ROLLING; MALE; MICROVASCULATURE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANGIOGENIC PROTEINS; ANIMALS; CELL ADHESION; CELLS, CULTURED; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; INFLAMMATORY BOWEL DISEASES; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33645815916     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00466.2005     Document Type: Article

References (43)

1. Abdelbaqi M, Chidlow JH, Matthews KM, Pavlick KP, Grisham MB, Fowler M, and Kevil CG. Regulation of dextran sodium sulfate-induced colitis by leukocyte β2 integrins. Lab Invest. In press.
2. Abreu MT. The pathogenesis of inflammatory bowel disease: translational implications for clinicians. Curr Gastroenterol Rep 4: 481-489, 2002.
3. Ando T, Jordan P, Wang Y, Itoh M, Joh T, Sasaki M, Elrod JW, Carpenter A, Jennings MH, Minagar A, and Alexander JS. MAd-CAM-1 expression and regulation in murine colonic endothelial cells in vitro. Inflamm Bowel Dis 11: 258-264, 2005.
4. Ardizzone S and Porro GB. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 252: 475-496, 2002.
5. tm1Bay PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease. Am J Pathol 163: 197-202, 2003.
6. Barlow SC, Langston W, Matthews KM, Chidlow JH Jr, and Kevil CG. CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes. Am J Pathol 165: 1849-1852, 2004.
7. Bendjelloul F, Maly P, Mandys V, Jirkovska M, Prokesova L, Tuckova L, and Tlaskalova-Hogenova H. Intercellular adhesion molecule-1 (ICAM-1) deficiency protects mice against severe forms of experimentally induced colitis. Clin Exp Immunol 119: 57-63, 2000.
8. Bousvaros A, Leichtner A, Zurakowski D, Kwon J, Law T, Keough K, and Fishman S. Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease. Dig Dis Sci 44: 424-430, 1999.
9. Carmeliet P and Collen D. Molecular analysis of blood vessel formation and disease. Am J Physiol Heart Circ Physiol 273: H2091-H2104, 1997.
10. Carmeliet P and Jain RK. Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
11. Chidlow J, Goebel S, Huang M, Langston W, Pavlick KP, Jennings M, Grisham MB, Alexander JS, and Kevil CG. Angiogenic inflammation in experimental colitis (Abstract). FASEB J 19: A1716, 2005.
12. Croll SD, Ransohoff RM, Cai N, Zhang Q, Martin FJ, Wei T, Kasselman LJ, Kintner J, Murphy AJ, Yancopoulos GD, and Wiegand SJ. VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol 187: 388-402, 2004.
13. Detmar M, Brown LF, Schon MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, and Jain RK. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 111: 1-6, 1998.
14. Elson CO, Sartor RB, Tennyson GS, and Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 109: 1344-1367, 1995.
15. Farthing MJ. Severe inflammatory bowel disease: medical management. Dig Dis 21: 46-53, 2003.
16. Fishman SJ, Feins NR, RJDA, and Folkman J. Long-term remission of Crohn's disease treated with thalidomide: a seminal case report. Angiogenesis 3: 201-204, 1999.
17. Harris ES, McIntyre TM, Prescott SM, and Zimmerman GA. The leukocyte integrins. J Biol Chem 275: 23409-23412, 2000.
18. L- Integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium. Am J Physiol Gastrointest Liver Physiol 288: G67-G73, 2005.
19. 164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 198: 483-489, 2003.
20. Ishida S, Yamashiro K, Usui T, Kaji Y, Ogura Y, Hida T, Honda Y, Oguchi Y, and Adamis AP. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med 9: 781-788, 2003.
21. Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, and Adamis AP. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18: 1450-1452, 2004.
22. Kanazawa S, Tsunoda T, Onuma E, Majima T, Kagiyama M, and Kikuchi K. VEGF, basic-FGF, and TGF-β in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 96: 822-828, 2001.
23. Kapsoritakis A, Sfiridaki A, Maltezos E, Simopoulos K, Giatromanolaki A, Sivridis E, and Koukourakis MI. Vascular endothelial growth factor in inflammatory bowel disease. Int J Colorectal Dis 18: 418-422, 2003.
24. Kevil CG. Endothelial cell activation in inflammation: lessons from mutant mouse models. Pathophysiology 9: 63-74, 2003.
25. Kevil CG and Bullard DC. Roles of leukocyte/endothelial cell adhesion molecules in the pathogenesis of vasculitis. Am J Med 106: 677-687, 1999.
26. Kevil CG, Chidlow JH, Bullard DC, and Kucik DF. High-temporal-resolution analysis demonstrates that ICAM-1 stabilizes WEHI 274.1 monocytic cell rolling on endothelium. Am J Physiol Cell Physiol 285: C112-C118, 2003.
27. lpr mice from autoimmune disease. Am J Pathol 165: 609-616, 2004.
28. Kevil CG, Payne DK, Mire E, and Alexander JS. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J Biol Chem 273: 15099-15103, 1998.
29. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, and Koh GY. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells. J Biol Chem 276: 7614-7620, 2001.
30. Kirk SL and Karlik SJ. VEGF and vascular changes in chronic neuroinflammation. J Autoimmun 21: 353-363, 2003.
31. Koch AE. Angiogenesis as a target in rheumatoid arthritis. Ann Rheum Dis 62, Suppl 2: ii60-ii67, 2003.
32. Kusugami K, Ina K, Ando T, Hibi K, Nishio Y, and Goto H. Immunomodulatory therapy for inflammatory bowel disease. J Gastroenterol 39: 1129-1137, 2004.
33. Miquerol L, Gertsenstein M, Harpal K, Rossant J, and Nagy A. Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol 212: 307-322, 1999.
34. Naldini A and Carraro F. Role of inflammatory mediators in angiogenesis. Curr Drug Targets Inflamm Allergy 4: 3-8, 2005.
35. Panes J. Inflammatory bowel disease: pathogenesis and targets for therapeutic interventions. Acta Physiol Scand 173: 159-165, 2001.
36. Pizarro TT, Arseneau KO, Bamias G, and Cominelli F. Mouse models for the study of Crohn's disease. Trends Mol Med 9: 218-222, 2003.
37. Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Geehan CS, Luster AD, Sayegh MH, and Briscoe DM. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest 112: 1655-1665, 2003.
38. Sartor RB. Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am J Gastroenterol 92: 5S-11S, 1997.
39. Spalinger J, Patriquin H, Miron MC, Marx G, Herzog D, Dubois J, Dubinsky M, and Seidman EG. Doppler US in patients with Crohn disease: vessel density in the diseased bowel reflects disease activity. Radiology 217: 787-791, 2000.
40. Thurston G and Gale NW. Vascular endothelial growth factor and other signaling pathways in developmental and pathologic angiogenesis. Int J Hematol 80: 7-20, 2004.
41. Wen Z and Fiocchi C. Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis? Clin Dev Immunol 11: 195-204, 2004.
42. Xia YP, Li B, Hylton D, Detmar M, Yancopoulos GD, and Rudge JS. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 102: 161-168, 2003.
43. Zollner O, Lenter MC, Blanks JE, Borges E, Steegmaier M, Zerwes HG, and Vestweber D. L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. J Cell Biol 136: 707-716, 1997.