Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of l-lysine production strains

Applied Microbiology and Biotechnology

Volumn 86, Issue 5, 2010, Pages 1313-1322

  Blombach, Bastian ^a   Seibold, Gerd M ^b  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Amino acid production; Carbohydrates; Corynebacterium glutamicum; L Lysine; Metabolic engineering; Sugar

Indexed keywords

AMINO ACID PRODUCTION; CARBOHYDRATE METABOLISM; CORYNEBACTERIUM GLUTAMICUM; D-RIBOSE; D-XYLOSE; L-ARABINOSE; L-LYSINE; L-LYSINE PRODUCTION; METABOLIC ENGINEERING; METABOLIC PATHWAYS; METABOLIZATION; PRODUCTION PROCESS; RATIONAL DESIGN;

CARBOHYDRATES; GLUCOSE; METABOLISM; ORGANIC ACIDS; SUGAR (SUCROSE); XYLOSE;

AMINO ACIDS;

ARABINOSE; CARBOHYDRATE; CELLOBIOSE; FRUCTOSE; GLUCONIC ACID; GLUCOSE; GLUCOSIDE; LYSINE; MALTOSE; RIBOSE; SUCROSE; XYLOSE;

AMINO ACID; BACTERIUM; CARBOHYDRATE; GENETIC ENGINEERING; METABOLISM;

BACTERIAL STRAIN; CARBOHYDRATE METABOLISM; CORYNEBACTERIUM GLUTAMICUM; METABOLIC ENGINEERING; NONHUMAN; SHORT SURVEY;

BIOSYNTHETIC PATHWAYS; CARBOHYDRATE METABOLISM; CORYNEBACTERIUM GLUTAMICUM; GENETIC ENGINEERING; LYSINE;

CORYNEBACTERIUM GLUTAMICUM;

EID: 77952889716     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2537-z     Document Type: Short Survey

References (75)

1. Arndt A, Eikmanns BJ (2008) Regulation of carbon metabolism in Corynebacterium glutamicum. In: Burkovski A (ed) Corynebacteria: genomics and molecular biology. Caister Academic, Norfolk, pp 155-182
2. C Bäumchen E Krings S Bringer L Eggeling H Sahm 2009 Myo-inositol facilitators IolT1 and IolT2 enhance D-mannitol formation from d-fructose in Corynebacterium glutamicum FEMS Microbiol Lett 290 227 235 10.1111/j.1574-6968. 2008.01425.x
3. E Barrett C Stanton O Zelder G Fitzgerald RP Ross 2004 Heterologous expression of lactose- and galactose-utilizing pathways from lactic acid bacteria in Corynebacterium glutamicum for production of lysine in whey J Bacteriol 70 2861 2866 1:CAS:528:DC%2BD2cXktlCnsLk%3D
4. J Becker C Klopprogge O Zelder E Heinzle C Wittmann 2005 Amplified expression of fructose 1, 6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources Appl Environ Microbiol 71 8587 8596 10.1128/AEM.71.12.8587-8596.2005 1:CAS:528:DC%2BD2MXhtlehtbvI (Pubitemid 41803992)
5. J Becker C Klopproge A Herold O Zelder CJ Bolten C Wittmann 2007 Metabolic flux engineering of l-lysine production in Corynebacterium glutamicum-over expression and modification of G6P dehydrogenase J Biotechnol 132 99 109 10.1016/j.jbiotec.2007.05.026 1:CAS:528:DC%2BD2sXht1amsr%2FK (Pubitemid 47599710)
6. J Becker C Klopprogge H Schröder C Wittmann 2009 Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum Appl Environ Microbiol 75 7866 7869 10.1128/AEM.01942-09 1:CAS:528:DC%2BD1MXhs1WgsrzF
7. B Blombach ME Schreiner M Moch M Oldiges BJ Eikmanns 2007 Effect of pyruvate dehydrogenase complex deficiency on l-lysine production with Corynebacterium glutamicum Appl Microbiol Biotechnol 76 615 623 10.1007/s00253-007-0904-1 1:CAS:528:DC%2BD2sXpt1ahtr8%3D (Pubitemid 47283123)
8. B Blombach A Arndt M Auchter BJ Eikmanns 2009 l-Valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR Appl Environ Microbiol 75 1197 1200 10.1128/AEM.02351-08 1:CAS:528:DC%2BD1MXitlCqsLo%3D
9. W Brabetz W Liebl KH Schleifer 1991 Studies on the utilization of lactose by Corynebacterium glutamicum, bearing the lactose operon of Escherichia coli Arch Microbiol 155 607 612 10.1007/BF00245357 1:CAS:528:DyaK3MXltFShtb0%3D
10. K Brinkrolf S Plöger S Solle I Brune SS Nentwich AT Hüser J Kalinowski A Pühler A Tauch 2008 The LacI/GalR family transcriptional regulator UriR negatively controls uridine utilization of Corynebacterium glutamicum by binding to catabolite-responsive element (cre)-like sequences Microbiology 154 1068 1081 10.1099/mic.0.2007/014001-0 1:CAS:528: DC%2BD1cXltleqsLs%3D (Pubitemid 351736264)
11. J Cremer L Eggeling H Sahm 1991 Control of the lysine biosynthesis sequence in Corynebacterium glutamicum as analyzed by overexpression of the individual corresponding genes Appl Environ Microbiol 57 1746 1752 1:CAS:528:DyaK3MXks1GltL4%3D
12. H Dominguez ND Lindley 1996 Complete sucrose metabolism requires fructose phosphotransferase activity in Corynebacterium glutamicum to ensure phosphorylation of liberated fructose Appl Environ Microbiol 62 3878 3880 1:CAS:528:DyaK28XmtVGqu78%3D
13. H Dominguez C Rollin A Guyonvarch JL Guerquin-Kern M Cocaign-Bousquet ND Lindley 1998 Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth on fructose Eur J Biochem 254 96 102 10.1046/j.1432-1327.1998.2540096.x 1:CAS:528:DyaK1cXjsVygtbs%3D (Pubitemid 28255074)
14. BJ Eikmanns 1992 Identification, sequence analysis, and expression of a Corynebacterium glutamicum gene cluster encoding the three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomerase J Bacteriol 174 6076 6086 1:CAS:528:DyaK3sXkvVOltLw%3D
15. V Engels VF Wendisch 2007 The DeoR-type regulator SugR represses expression of ptsG in Corynebacterium glutamicum J Bacteriol 189 2955 2966 10.1128/JB.01596-06 1:CAS:528:DC%2BD2sXkslGqsbw%3D (Pubitemid 46697384)
16. V Engels T Georgi VF Wendisch 2008 ScrB (Cg2927) is a sucrose-6-phosphate hydrolase essential for sucrose utilization by Corynebacterium glutamicum FEMS Microbiol Lett 289 80 89 10.1111/j.1574-6968.2008.01370.x 1:CAS:528: DC%2BD1cXhsVOhu7fK
17. J Frunzke V Engels S Hasenbein C Gätgens M Bott 2008 Co-ordinated regulation of gluconate catabolism and glucose uptake in Corynebacterium glutamicum by two functionally equivalent transcriptional regulators, GntR1 and GntR2 Mol Microbiol 67 305 322 1:CAS:528:DC%2BD1cXhslGhsbY%3D
18. T Georgi D Rittmann VF Wendisch 2005 Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: roles of malic enzyme and fructose-1, 6-bisphosphatase Metab Eng 7 291 301 10.1016/j.ymben. 2005.05.001 1:CAS:528:DC%2BD2MXpslymu7k%3D (Pubitemid 41225446)
19. P Gourdon M Raherimandimby H Dominguez M Cocaign-Bousquet ND Lindley 2003 Osmotic stress, glucose transport capacity and consequences for glutamate overproduction in Corynebacterium glutamicum J Biotechnol 104 77 85 10.1016/S0168-1656(03)00165-2 1:CAS:528:DC%2BD3sXmslens70%3D (Pubitemid 37011350)
20. T Hermann 2003 Industrial production of amino acids by coryneform bacteria J Biotechnol 104 155 172 10.1016/S0168-1656(03)00149-4 1:CAS:528:DC%2BD3sXmslens7Y%3D (Pubitemid 37011355)
21. M Ikeda S Nakagawa 2003 The Corynebacterium glutamicum genome: features and impacts on biotechnological processes Appl Microbiol Biotechnol 62 99 109 10.1007/s00253-003-1328-1 1:CAS:528:DC%2BD3sXls1ajsLk%3D (Pubitemid 36995160)
22. Jojima T, Omumasaba CA, Inui M, Yukawa H (2010) Sugar transporters in efficient utilization of mixed sugar substrates: current knowledge and outlook. Appl Microbiol Biotechnol 85:471-480
23. A Kabus T Georgi VF Wendisch M Bott 2007 Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves l-lysine formation Appl Microbiol Biotechnol 75 47 53 10.1007/s00253-006-0804-9 1:CAS:528:DC%2BD2sXks1ahtbk%3D (Pubitemid 46669231)
24. J Kalinowski B Bathe D Bartels N Bischoff M Bott A Burkovski N Dusch L Eggeling BJ Eikmanns L Gaigalat A Goesmann M Hartmann K Huthmacher R Krämer B Linke AC McHardy F Meyer B Möckel W Pfefferle A Pühler DA Rey C Rückert O Rupp H Sahm VF Wendisch I Wiegräbe A Tauch 2003 The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins J Biotechnol 104 5 25 10.1016/S0168-1656(03)00154-8 1:CAS:528:DC%2BD3sXmslensrY%3D (Pubitemid 37011345)
25. H Kawaguchi AA Vertès S Okino M Inui H Yukawa 2006 Engineering of a xylose metabolic pathway in Corynebacterium glutamicum Appl Environ Microbiol 72 3418 3428 10.1128/AEM.72.5.3418-3428.2006 1:CAS:528:DC%2BD28XkvFWjs7c%3D (Pubitemid 43740465)
26. H Kawaguchi M Sasaki AA Vertès M Inui H Yukawa 2007 Engineering of an l-arabinose metabolic pathway in Corynebacterium glutamicum Appl Microbiol Biotechnol 77 1053 1062 10.1007/s00253-007-1244-x
27. H Kawaguchi M Sasaki AA Vertès M Inui H Yukawa 2009 Identification and functional analysis of the gene cluster for l-arabinose utilization in Corynebacterium glutamicum Appl Environ Microbiol 75 3419 3429 10.1128/AEM.02912-08 1:CAS:528:DC%2BD1MXntlShtbw%3D
28. Kelle R, Hermann T, Bathe B (2005) l-Lysine production. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 465-488
29. P Kiefer E Heinzle O Zelder C Wittmann 2004 Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose Appl Environ Microbiol 70 229 239 10.1128/AEM.70.1.229-239.2004 1:CAS:528:DC%2BD2cXmvFahtQ%3D%3D (Pubitemid 38090208)
30. P Kotrba M Inui H Yukawa 2001 The ptsI gene encoding enzyme I of the phosphotransferase system of Corynebacterium glutamicum Biochem Biophys Res Commun 289 1307 1313 10.1006/bbrc.2001.6116 1:CAS:528:DC%2BD3MXptVWis7w%3D (Pubitemid 34076335)
31. O Kotrba M Inui H Yukawa 2003 A single V317A or V317M substitution in enzyme II of a newly identified β-glucoside phosphotransferase and utilization system of Corynebacterium glutamicum R extends its specificity towards cellobiose Microbiology 149 1569 1580 10.1099/mic.0.26053-0 1:CAS:528:DC%2BD3sXkvFSjtLY%3D
32. FS Krause A Henrich B Blombach R Krämer BJ Eikmanns GM Seibold 2010 Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of l-valine productivity Appl Environ Microbiol 76 370 374 10.1128/AEM.01553-09 1:CAS:528:DC%2BC3cXntFOrtQ%3D%3D
33. JK Lee MH Sung KH Yoon JH Yu TK Oh 1994 Nucleotide sequence of the gene encoding the Corynebacterium glutamicum mannose enzyme II and analyses of the deduced protein sequence FEMS Microbiol Lett 119 137 145 10.1111/j.1574-6968. 1994.tb06880.x 1:CAS:528:DyaK2cXlt1Knur8%3D
34. HW Lee JG Pan JM Lebeault 1998 Enhanced l-lysine production in the threonine-limited continuous culture of Corynebacterium glutamicum by using gluconate as a secondary carbon source with glucose Appl Microbiol Biotechnol 49 9 15 10.1007/s002530051130 1:CAS:528:DyaK1cXhtVantLc%3D (Pubitemid 28055375)
35. M Letek N Valbuena A Ramos E Ordóñez JA Gil LM Mateos 2006 Characterization and use of catabolite-repressed promoters from gluconate genes in Corynebacterium glutamicum J Bacteriol 188 409 423 10.1128/JB.188.2.409-423. 2006 1:CAS:528:DC%2BD28Xms1KqsQ%3D%3D (Pubitemid 43100528)
36. Liebl W (2005) Corynebacterium taxonomy. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 9-34
37. A Marx AA de Graaf W Wiechert L Eggeling H Sahm 1996 Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing Biotechnol Bioeng 49 111 129 10.1002/(SICI)1097-0290(19960120)49:2<111::AID-BIT1>3.0. CO;2-T 1:STN:280:DC%2BD1cvkvFWiug%3D%3D (Pubitemid 26011765)
38. A Marx K Striegel AA de Graaf L Eggeling 1997 Response of central metabolism of Corynebacterium glutamicum to different flux burdens Biotechnol Bioeng 56 168 180 10.1002/(SICI)1097-0290(19971020)56:2<168::AID-BIT6>3.0. CO;2-N 1:CAS:528:DyaK2sXmsV2ks78%3D (Pubitemid 27430895)
39. A Marx S Hans B Möckel B Bathe AA de Graaf 2003 Metabolic phenotype of phosphoglucose isomerase mutants of Corynebacterium glutamicum J Biotechnol 104 185 197 10.1016/S0168-1656(03)00153-6 1:CAS:528:DC%2BD3sXmslensL4%3D (Pubitemid 37011357)
40. S Mitsuhashi M Hayashi J Ohnishi M Ikeda 2006 Disruption of malate:quinone oxidoreductase increases l-lysine production by Corynebacterium glutamicum Biosci Biotechnol Biochem 70 2803 2806 10.1271/bbb.60298 1:CAS:528:DC%2BD28XhtlSit7jL (Pubitemid 44819862)
41. MW Moon HJ Kim TK Oh CS Shin JS Lee SJ Kim JK Lee 2005 Analyses of enzyme II gene mutants for sugar transport and heterologous expression of fructokinase gene in Corynebacterium glutamicum ATCC 13032 FEMS Microbiol Lett 244 259 266 10.1016/j.femsle.2005.01.053 1:CAS:528:DC%2BD2MXit1Cisb8%3D (Pubitemid 40342837)
42. B Moritz K Striegel AA de Graaf H Sahm 2000 Kinetic properties of the glucose-6-phosphate and 6-phosphogluconate dehydrogenases from Corynebacterium glutamicum and their application for predicting pentose pathway flux in vivo Eur J Biochem 267 3442 3452 10.1046/j.1432-1327.2000.01354.x 1:CAS:528: DC%2BD3cXksVKgtr8%3D (Pubitemid 30423003)
43. B Moritz K Striegel AA de Graaf H Sahm 2002 Changes of pentose phosphate pathway flux in vivo in Corynebacterium glutamicum during leucine-limited batch cultivation as determined from intracellular metabolite concentration measurements Metab Eng 4 295 305 10.1006/mben.2002.0233 1:CAS:528: DC%2BD3sXpvFSjtg%3D%3D (Pubitemid 36035672)
44. K Nakayama H Tanaka H Hagino S Kinoshita 1966 Studies on lysine fermentation. V. Concerted feedback inhibition of aspartokinase and the absence of lysine inhibition on aspartic semialdehyde-pyruvate condensation in Micrococcus glutamicus Agric Biol Chem 30 611 616 1:CAS:528:DyaF28XksVSrtrk%3D
45. SS Nentwich K Brinkrolf L Gaigalat AT Hüser DA Rey T Mohrbach K Marin A Pühler A Tauch J Kalinowski 2009 Characterization of the LacI-type transcriptional repressor RbsR controlling ribose transport in Corynebacterium glutamicum ATCC 13032 Microbiology 155 150 164 10.1099/mic.0.020388-0 1:CAS:528:DC%2BD1MXht12rtLw%3D
46. J Ohnishi S Mitsuhashi M Hayashi S Ando H Yokoi K Ochiai M Ikeda 2002 A novel methodology employing Corynebacterium glutamicum genome information to generate a new l-lysine producing mutant Appl Microbiol Biotechnol 58 217 223 10.1007/s00253-001-0883-6 1:STN:280:DC%2BD387ksVegtA%3D%3D (Pubitemid 34118998)
47. J Ohnishi R Katahira S Mitsuhashi S Kakita M Ikeda 2005 A novel gnd mutation leading to increased l-lysine production in Corynebacterium glutamicum FEMS Microbial Lett 242 265 274 10.1016/j.femsle.2004.11.014 1:CAS:528:DC%2BD2cXhtFGhtrbK (Pubitemid 40038398)
48. CA Omumasaba N Okai M Inui H Yokawa 2004 Corynebacterium glutamicum glyceraldehyde-3-phosphate dehydrogenase isoforms with opposite, ATP-dependent regulation J Mol Microbiol Biotechnol 8 91 103 10.1159/000084564 1:CAS:528:DC%2BD2MXks1ertLs%3D (Pubitemid 41244120)
49. S Parche A Burkovski GA Sprenger B Weil R Krämer F Titgemeyer 2001 Corynebacterium glutamicum: a dissection of the PTS J Mol Microbiol Biotechnol 3 423 428 1:CAS:528:DC%2BD3MXjsVynurw%3D
50. SY Park HK Kim SK Yoo TK Oh JK Lee 2000 Characterization of glk, a gene coding for glucose kinase of Corynebacterium glutamicum FEMS Microbiol Lett 188 209 215 10.1111/j.1574-6968.2000.tb09195.x 1:CAS:528:DC%2BD3cXksFGisbs%3D
51. Pátek M (2007) Branched chain amino acids. In: Wendisch VF (ed) Amino acid biosynthesis-pathways, regulation and metabolic engineering. Springer, Heidelberg, pp 129-162
52. PG Peters-Wendisch B Schiel VF Wendisch E Katsoulidis B Möckel H Sahm BJ Eikmanns 2001 Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum J Mol Microbiol Biotechnol 3 295 300 1:CAS:528:DC%2BD3MXisFSrtL4%3D
53. A Pons CG Dussap C Péquignot JB Gros 1996 Metabolic flux distribution in Corynebacterium melassecola ATCC 17965 for various carbon sources Biotechnol Bioeng 51 177 189 10.1002/(SICI)1097-0290(19960720)51: 2<177::AID-BIT7>3.0.CO;2-G (Pubitemid 26187025)
54. E Radmacher L Eggeling 2007 The three tricarboxylate synthase activities of Corynebacterium glutamicum and increase of l-lysine synthesis Appl Microbiol Biotechnol 76 587 595 10.1007/s00253-007-1105-7 1:CAS:528:DC%2BD2sXpt1ahsbg%3D (Pubitemid 47283121)
55. C Riedel D Rittmann P Dangel B Möckel H Sahm BJ Eikmanns 2001 Characterization, expression, and inactivation of the phosphoenolpyruvate carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production J Mol Microbiol Biotechnol 3 573 583 1:CAS:528:DC%2BD3MXmsVartbo%3D
56. D Rittmann S Schaffer VF Wendisch H Sahm 2003 Fructose-1, 6-bisphosphatase from Corynebacterium glutamicum: expression and deletion of the fbp gene and biochemical characterization of the enzyme Arch Microbiol 180 285 292 10.1007/s00203-003-0588-6 1:CAS:528:DC%2BD3sXnslSnur4%3D (Pubitemid 37260457)
57. M Sasaki T Jojima H Kawaguchi M Inui H Yukawa 2008 Simultaneous utilization of d-cellobiose, d-glucose, and d-xylose by recombinant Corynebacterium glutamicum under oxygen-deprived conditions Appl Microbiol Biotechnol 81 691 699 10.1007/s00253-008-1703-z 1:CAS:528:DC%2BD1cXhsVCntb3F
58. M Sasaki T Jojima H Kawaguchi M Inui H Yukawa 2009 Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars Appl Microbiol Biotechnol 85 105 115 10.1007/s00253-009-2065-x 1:CAS:528:DC%2BD1MXht12ms7nP
59. B Schrumpf L Eggeling H Sahm 1992 Isolation and prominent characteristics of an l-lysine hyperproducing strain of Corynebacterium glutamicum Appl Microbiol Biotechnol 37 566 571 10.1007/BF00240726 1:CAS:528:DyaK38XmtFSltLY%3D
60. G Seibold M Auchter S Berens J Kalinowski BJ Eikmanns 2006 Utilization of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production J Biotechnol 124 381 391 10.1016/j.jbiotec.2005.12.027 1:CAS:528:DC%2BD28XlvFGitrg%3D
61. GM Seibold M Wurst BJ Eikmanns 2009 Roles of maltodextrin and glycogen phosphorylases in maltose utilization and glycogen metabolism in Corynebacterium glutamicum Microbiology 155 347 358 10.1099/mic.0.023614-0 1:CAS:528: DC%2BD1MXitlCrsL8%3D
62. I Shiio R Miyajima 1969 Concerted inhibition and its reversal by end products of aspartate kinase in Brevibacterium flavum J Biochem (Tokyo) 5 849 859
63. I Shiio H Ozaki K Ujigawa-Takeda 1982 Production of aspartic acid and lysine by citrate synthase mutants of Brevibacterium flavum Agric Biol Chem 46 101 107 1:CAS:528:DyaL38Xht1SktbY%3D
64. Sprenger GA (2007) Aromatic amino acids. In: Wendisch VF (ed) Amino acid biosynthesis-pathways, regulation and metabolic engineering. Springer, Heidelberg, pp 93-127
65. M Stolz P Peters-Wendisch H Etterich T Gerharz R Faurie H Sahm H Fersterra L Eggeling 2007 Reduced folate supply as a key to enhanced l-serine production by Corynebacterium glutamicum Appl Environ Microbiol 73 750 755 10.1128/AEM.02208-06 1:CAS:528:DC%2BD2sXltlals78%3D (Pubitemid 46233490)
66. Y Tanaka H Teramoto M Inui H Yukawa 2009 Identification of a second β-glucoside phosphoenolpyruvate:carbohydrate phosphotransferase system in Corynebacterium glutamicum R Microbiology 155 3652 3660 10.1099/mic.0.029496-0 1:CAS:528:DC%2BD1MXhsFeksb%2FO
67. T Tateno H Fukuda A Kondo 2007 Production of l-lysine from starch by Corynebacterium glutamicum displaying α-amylase on its cell surface Appl Microbiol Biotechnol 74 1213 1220 10.1007/s00253-006-0766-y 1:CAS:528: DC%2BD2sXks1agsrg%3D (Pubitemid 46674061)
68. T Tateno H Fukuda A Kondo 2007 Direct production of l-lysine from raw corn starch by Corynebacterium glutamicum secreting Streptococcus bovis α-amylase using cspB promoter and signal sequence Appl Microbiol Biotechnol 77 533 541 10.1007/s00253-007-1191-6 1:CAS:528:DC%2BD2sXht12ktLrE (Pubitemid 350125507)
69. T Tateno Y Okada T Tsuchidate T Tanaka H Fukuda A Kondo 2009 Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing alpha-amylase and lysine decarboxylase Appl Microbiol Biotechnol 82 115 121 10.1007/s00253-008-1751-4 1:CAS:528:DC%2BD1MXntVOmug%3D%3D
70. Udaka S (2008) The discovery of Corynebacterium glutamicum and birth of amino acid fermentation industry in Japan. In: Burkovski A (ed) Corynebacteria: genomics and molecular biology. Caister Academic, Norfolk, pp 1-6
71. JJ Vallino G Stephanopoulos 1994 Carbon flux distributions at the glucose-6-phosphate branch point in Corynebacterium glutamicum during lysine overproduction Biotechnol Prog 10 327 334 10.1021/bp00027a014 1:CAS:528:DyaK2cXktVOgtro%3D (Pubitemid 2099393)
72. VF Wendisch M Bott BJ Eikmanns 2006 Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids Curr Opin Microbiol 9 268 274 10.1016/j.mib.2006.03.001 1:CAS:528:DC%2BD28Xltlelt7c%3D (Pubitemid 44183577)
73. Winnen B, Felce J, Saier MH Jr (2005) Genomic analyses of transport proteins in Corynebacterium glutamicum and Corynebacterium efficiens. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 149-186
74. Yokota A, Lindley ND (2005) Central metabolism: sugar uptake and conversion. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 215-240
75. H Yukawa CA Omumasaba H Nonaka P Kós N Okai N Suzuki M Suda Y Tsuge J Watanabe Y Ikeda AA Vertès M Inui 2007 Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R Microbiology 153 1042 1058 10.1099/mic.0.2006/003657-0 1:CAS:528: DC%2BD2sXkvVemsrg%3D (Pubitemid 46605802)