MDL-28170 has no analgesic effect on CCI induced neuropathic pain in mice

Molecules

Volumn 15, Issue 5, 2010, Pages 3038-3047

  Üçeyler, Nurcan ^a   Biko, Lydia ^a   Sommer, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Calpain; Chronic constriction nerve injury (CCI); MDL 28170; Neuropathic pain

Indexed keywords

ANALGESIC AGENT; CALPAIN; CALPAIN INHIBITOR III; CYSTEINE PROTEINASE INHIBITOR; CYTOKINE; DIPEPTIDE;

ANALGESIA; ANIMAL; ARTICLE; C57BL MOUSE; DRUG ANTAGONISM; IMMUNOLOGY; INJURY; METHODOLOGY; MOUSE; PAIN ASSESSMENT; SCIATIC NERVE; SCIATIC NEUROPATHY; STENOSIS, OCCLUSION AND OBSTRUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; COMPLICATION; CONSTRICTION, PATHOLOGIC; PAIN MEASUREMENT; PROCEDURES;

ANALGESIA; ANALGESICS; ANIMALS; CALPAIN; CONSTRICTION, PATHOLOGIC; CYSTEINE PROTEINASE INHIBITORS; CYTOKINES; DIPEPTIDES; MICE; MICE, INBRED C57BL; PAIN MEASUREMENT; SCIATIC NERVE; SCIATIC NEUROPATHY; UP-REGULATION;

EID: 77952849731     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15053038     Document Type: Article

References (26)

1. Üçeyler, N.; Tscharke, A.; Sommer, C. Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain. Brain Behav. Immun 2007, 21, 553-560.
2. Chan, S.L.; Mattson, M.P. Caspase and calpain substrates: roles in synaptic plasticity and cell death. J. Neurosci. Res. 1999, 55, 167-190.
3. Li, G.; Iyengar, R. Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta - catenin-regulated cell proliferation. Proc. Natl. Acad. Sci. USA 2002, 99, 13254-13259.
4. Neumar, R.W.; Xu, Y.A.; Gada, H.; Guttmann, R.P.; Siman, R. Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J. Biol. Chem. 2003, 275, 14162-14167.
5. Saito, Y.; Saido, T.C.; Sano, K.; Kawashima, S. The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells. FEBS Lett. 1994, 353, 327-331.
6. Hall, S. Mechanisms of repair after traumatic injury. In Peripheral neuropathy; Dyck, P.J., Thomas, P.K., Eds.; Elsevier Saunders: Philadelphia, PA, USA, 2005; pp. 1403-1433.
7. Kunz, S.; Niederberger, E.; Ehnert, C.; Coste, O.; Pfenninger, A.; Kruip, J.; Wendrich, T.M.; Schmidtko, A.; Tegeder, I.; Geisslinger, G. The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia. Pain 2004, 110, 409-418.
8. Wang, M.S.; Wu, Y.; Culver, D.G.; Glass, J.D. Pathogenesis of axonal degeneration: Parallels between Wallerian degeneration and vincristine neuropathy. J. Neuropathol. Exp. Neurol. 2000, 59, 599-606.
9. Joshi, A.; Bondada, V.; Geddes, J.W. Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor. Exp. Neurol. 2009, 218, 221-227.
10. Lopez-Meraz, M.L.; Niquet, J. Participation of mu-calpain in status epilepticus-induced hippocampal injury. Brain Res. Bull. 2009, 78, 131.
11. Nakazawa, T.; Shimura, M.; Mourin, R.; Kondo, M.; Yokokura, S.; Saido, T.C.; Nishida, K.; Endo, S. Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells. J. Neurosci. Res. 2009, 87, 1412-1423.
12. Ai, J.; Liu, E.; Wang, J.; Chen, Y.; Yu, J.; Baker, A.J. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J. Neurotrauma. 2007, 24, 960-978.
13. Arataki, S.; Tomizawa, K.; Moriwaki, A.; Nishida, K.; Matsushita, M.; Ozaki, T.; Kunisada, T.; Yoshida, A.; Inoue, H.; Matsui, H. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J. Neurotrauma. 2005, 22, 398-406.
14. Buki, A.; Farkas, O.; Doczi, T.; Povlishock, J.T. Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury. J. Neurotrauma. 2003, 20, 261-268.
15. Kawamura, M.; Nakajima, W.; Ishida, A.; Ohmura, A.; Miura, S.; Takada, G. Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis. Brain Res. 2005, 1037, 59-69.
16. Yu, C.G.; Geddes, J.W. Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury. Neurochem. Res. 2007, 32, 2046-2053.
17. Üçeyler, N.; Tscharke, A.; Sommer, C. Early cytokine gene expression in mouse CNS after peripheral nerve lesion. Neurosci. Lett. 2008, 436, 259-264.
18. Crocker, S.J.; Smith, P.D.; Jackson-Lewis, V.; Lamba, W.R.; Hayley, S.P.; Grimm, E.; Callaghan, S.M.; Slack, R.S.; Melloni, E.; Przedborski, S.; Robertson, G.S.; Anisman, H.; Merali, Z.; Park, D. S. Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. J. Neurosci. 2003, 23, 4081-4091.
19. Marques, J.M.; Belza, I.; Holtmann, B.; Pennica, D.; Prieto, J.; Bustos, M. Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis. Hepatology 2007, 45, 639-648
20. Wang, C.H.; Chen, Y.J.; Lee, T.H.; Chen, Y.S.; Jawan, B.; Hung, K.S.; Lu, C.N.; Liu, J.K. Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice. J. Biomed. Sci. 2004, 11, 571-578.
21. Li, P.A.; Howlett, W.; He, Q.P.; Miyashita, H.; Siddiqui, M.; Shuaib, A. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci. Lett. 1998, 247, 17-20.
22. Wang, S.; Wang, S.; Shan, P.; Song, Z.; Dai, T.; Wang, R.; Chi, Z. Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine- induced status epilepticus. Brain Res. Bull. 2008, 76, 90-96.
23. Bennett, G.J.; Xie, Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33, 87-107.
24. Sommer, C.; Schäfers, M. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. Brain Res. 1998, 784, 154-162.
25. Chaplan, S.R.; Bach, F.W.; Pogrel, J.W.; Chung, J.M.; Yaksh, T.L. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods 1994, 53, 55-63.
26. Hargreaves, K.; Dubner, R.; Brown, F.; Flores, C.; Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32, 77-88.