PMA activation of macrophages alters macrophage metabolism of aggregated LDL

Journal of Lipid Research

Volumn 43, Issue 8, 2002, Pages 1275-1282

  Huang, Wei ^a   Ishii, Itsuko ^a   Zhang, Wei Yang ^a   Sonobe, Miyahiko ^a   Kruth, Howard S ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acyl CoA:cholesterol acyltransferase; Atherosclerosis; Cholesterol; Endocytosis; Low density lipoprotein; Lysosomes; Patocytosis; Phorbol myristate acetate; Plasmin; Protein kinase C; Surface connected compartments; Trichloroacetic acid

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CHOLESTEROL; CHOLESTEROL ESTER; IODINE 125; LOW DENSITY LIPOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PLASMIN; PLASMINOGEN; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UROKINASE;

ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; LIPID METABOLISM; LIPID STORAGE; MACROPHAGE ACTIVATION; MONOCYTE; PRIORITY JOURNAL;

EID: 0036690919     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.m100436-jlr200     Document Type: Article

References (36)

1. The response-to-retention hypothesis of early atherogenesis
2. Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue
3. Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages
4. Lipoprotein aggregation as an essential condition of intracellular lipid accumulation caused by modified low density lipoproteins
5. Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages
6. Phagocytosis of aggregated lipoprotein by macrophages: Low density lipoprotein receptor-dependent foam-cell formation
7. Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL) particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans
8. Enhanced macrophage uptake of low density lipoprotein after self-aggregation
9. Aggregated low density lipoprotein induces and enters surface-connected compartments of human monocyte-macrophages. Uptake occurs independently of the low density lipoprotein receptor
10. Plasmin-mediated macrophage reversal of low density lipoprotein aggregation
11. Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux
12. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
13. Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells
14. Protein measurement with the folin phenol reagent
15. Binding of plasminogen to cultured human endothelial cells
16. Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor
17. Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages
18. In vivo and in vitro localization of Leishmania within macrophage phagolysosomes: Use of colloidal gold as a lysosomal label
19. The use of albumin-gold to follow lysosome-phagosome fusion
20. Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media
21. Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core
22. Histochemical detection of esterified cholesterol within human atherosclerotic lesions using the fluorescent probe filipin
23. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
24. Interaction of free apolipoproteins with macrophages. Formation of high density lipoproteinlike lipoproteins and reduction of cellular cholesterol
25. Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: Stimulation by high density lipoprotein and other agents
26. Selective down-regulation by protein kinase C inhibitors of apolipoprotein-mediated cellular cholesterol efflux in macrophages
27. Independent regulation of cholesterol incorporation into free apolipoprotein-mediated cellular lipid efflux in rat vascular smooth muscle cells
28. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol
29. Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage
30. The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions
31. The effect of macrophage stimulation on the uptake of acetylated low-density lipoproteins
32. Desialylated LDL uptake in human and mouse macrophages can be mediated by a lectin receptor
33. Effects of phorbol 12-myristate 13-acetate on triglyceride and cholesteryl ester synthesis in cultured coronary smooth muscle cells and macrophages
34. Cholesterol metabolism and efflux in human THP-1 macrophages
35. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
36. Sequestration of aggregated LDL by macrophages studied with freezeetch electron microscopy