Periadventitial delivery of anti-EGF receptor antibody inhibits neointimal macrophage accumulation after angioplasty in a hypercholesterolaemic rabbit

International Journal of Experimental Pathology

Volumn 91, Issue 3, 2010, Pages 224-234

  Shafi, Shahida ^a   Lamb, David ^a   Modjtahedi, Helmout ^a   Ferns, Gordon ^a,b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

Author keywords

Angioplasty; Atherosclerosis; EGFR; Macrophages; Neointima formation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; HEPARIN BINDING EPIDERMAL GROWTH FACTOR;

ANGIOPLASTY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BALLOON CATHETER; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CHOLESTEROL DIET; COMMON CAROTID ARTERY; CONTROLLED STUDY; EXPERIMENTAL RABBIT; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; INTIMA; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SMOOTH MUSCLE FIBER;

ANGIOPLASTY, BALLOON; ANIMALS; ANTIBODIES, MONOCLONAL; CAROTID ARTERIES; CELL MOVEMENT; CHEMOTAXIS, LEUKOCYTE; CONNECTIVE TISSUE; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; HYPERCHOLESTEROLEMIA; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MUSCLE, SMOOTH, VASCULAR; RABBITS; TUNICA INTIMA;

EID: 77952683787     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2009.00700.x     Document Type: Article

References (36)

1. Biwa T., Sakai M., Shichiri M., Horiuchi S. (2000) Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation. J. Atheroscler. Thromb. 7, 14 20.
2. Boucher I., Yang L., Mayo C., Klepeis V., Trinkaus-Randall V. (2007) Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway. Exp. Eye Res. 85, 130 141.
3. Chan A.K., Kalmes A., Hawkins S., Daum G., Clowes A.W. (2003) Blockade of the epidermal growth factor receptor decreases intimal hyperplasia in balloon-injured rat carotid artery. J. Vasc. Surg. 37, 644 649.
4. Charo I.F. Taubman M.B. (2004) Chemokines in the pathogenesis of vascular disease. Circ. Res. 95, 858 866.
5. Cunningham M.P., Thomas H., Fan Z., Modjtahedi H. (2006) Responses of human colorectal tumor cells to treatment with the anti-epidermal growth factor receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib. Cancer Res. 66, 7708 7715.
6. Davies M.G. Hagen P.O. (1995) Pathophysiology of vein graft failure: a review. Eur. J. Vasc. Endovasc. Surg. 9, 7 18.
7. Dreux A.C., Lamb D.J., Modjtahedi H., Ferns G.A. (2006) The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. Atherosclerosis 186, 38 53.
8. Edwards I.J., Xu H., Obunike J.C., Goldberg I.J., Wagner W.D. (1995) Differentiated macrophages synthesize a heparan sulfate proteoglycan and an oversulfated chondroitin sulfate proteoglycan that bind lipoprotein lipase. Arterioscler. Thromb. Vasc. Biol. 15, 400 409.
9. Ferns G.A., Sprugel K.H., Seifert R.A. et al. (1990) Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF. Growth Factors 3, 315 324.
10. George S.J. (1998) Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis. Curr. Opin. Lipidol. 9, 413 423.
11. Hansson G.K. (2005) Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352, 1685 1695.
12. Higashiyama S., Abraham J.A., Klagsbrun M. (1993) Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate. J. Cell Biol. 122, 933 940.
13. Kalmes A., Vesti B.R., Daum G., Abraham J.A., Clowes A.W. (2000) Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor. Circ. Res. 87, 92 98.
14. Khurana R., Shafi S., Martin J., Zachary I. (2004) Vascular endothelial growth factor gene transfer inhibits neointimal macrophage accumulation in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 24, 1074 1080.
15. Kim S.E., Lee W.J., Choi K.Y. (2007) The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation. Cell. Signal. 19, 511 518.
16. Lamb D.J., Modjtahedi H., Plant N.J., Ferns G.A. (2004) EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques. Atherosclerosis 176, 21 26.
17. Lamb D.J., Tickner M.L., Hourani S.M., Ferns G.A. (2005) Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis. Int. J. Exp. Pathol. 86, 247 255.
18. Miyagawa J., Higashiyama S., Kawata S. et al. (1995) Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques. J. Clin. Invest. 95, 404 411.
19. Modjtahedi H., Styles J.M., Dean C.J. (1993) The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468. Br. J. Cancer 67, 247 253.
20. Modjtahedi H., Affleck K., Stubberfield C., Dean C. (1998a) EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. Int. J. Oncol. 13, 335 342.
21. Modjtahedi H., Komurasaki T., Toyoda H., Dean C. (1998b) Anti-EGFR monoclonal antibodies which act as EGF, TGF alpha, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours. Int. J. Cancer 75, 310 316.
22. Mograbi B., Rochet N., Imbert V. et al. (1997) Human monocytes express amphiregulin and heregulin growth factors upon activation. Eur. Cytokine Netw. 8, 73 81.
23. Namba K., Nishio M., Mori K. et al. (2001) Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes. Cell. Immunol. 213, 104 113.
24. Normanno N., De Luca A., Bianco C. et al. (2006) Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 366, 2 16.
25. Panutsopulos D., Arvanitis D.L., Tsatsanis C., Papalambros E., Sigala F., Spandidos D.A. (2005) Expression of heregulin in human coronary atherosclerotic lesions. J. Vasc. Res. 42, 463 474.
26. Raab G. Klagsbrun M. (1997) Heparin-binding EGF-like growth factor. Biochim. Biophys. Acta 1333, F179 F199.
27. Reape T.J., Wilson V.J., Kanczler J.M., Ward J.P., Burnand K.G., Thomas C.R. (1997) Detection and cellular localization of heparin-binding epidermal growth factor-like growth factor mRNA and protein in human atherosclerotic tissue. J. Mol. Cell. Cardiol. 29, 1639 1648.
28. Ross R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801 809.
29. Scholes A.G., Hagan S., Hiscott P., Damato B.E., Grierson I. (2001) Overexpression of epidermal growth factor receptor restricted to macrophages in uveal melanoma. Arch. Ophthalmol. 119, 373 377.
30. Suc I., Meilhac O., Lajoie-Mazenc I. et al. (1998) Activation of EGF receptor by oxidized LDL. FASEB J. 12, 665 671.
31. Tamura R., Miyagawa J., Nishida M. et al. (2001) Immunohistochemical localization of Betacellulin, a member of epidermal growth factor family, in atherosclerotic plaques of human aorta. Atherosclerosis 155, 413 423.
32. Tokumaru S., Higashiyama S., Endo T. et al. (2000) Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J. Cell Biol. 151, 209 220.
33. Tomita M., Hirata Y., Uchihashi M., Fujita T. (1986) Characterization of epidermal growth factor receptors in cultured vascular smooth muscle cells of rat aorta. Endocrinol. Jpn. 33, 177 184. (Pubitemid 17069938)
34. Trieu V.N., Narla R.K., Myers D.E., Uckun F.M. (2000) EGF-genistein inhibits neointimal hyperplasia after vascular injury in an experimental restenosis model. J. Cardiovasc. Pharmacol. 35, 595 605.
35. Yamashita A., Shoji K., Tsuruda T. et al. (2008) Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery. Histol. Histopathol. 23, 127 136.
36. Yarden Y. Sliwkowski M.X. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2, 127 137.