3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 298, Issue 6, 2010, Pages

  Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Geranylgeranyltransferase; Internal anal sphincter; Mevalonate; Rho kinase

Indexed keywords

GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PHYTOENE SYNTHASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; CELLULAR DISTRIBUTION; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; NONHUMAN; PATHOPHYSIOLOGY; PRENYLATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SMOOTH MUSCLE FIBER MEMBRANE; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE;

ANIMALS; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PRENYLATION; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIMVASTATIN;

EID: 77952677228     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00034.2010     Document Type: Article

References (40)

1. Adamson P, Paterson HF, Hall A. Intracellular localization of the P21 rho proteins. J Cell Biol 119: 617-627, 1992.
2. Allai C, Favre G, Couderc B, Salicio S, Sixou S, Hamilton AD, Sebti SM, Lajoie-Mazenc I, Pradines A. Rho A prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription. J Biol Chem 275: 31001-31008, 2000.
3. Alvarez de Sotomayor M, Herrera MD, Marhuenda E, Andriantsitohaina R. Characterization of endothelial factors involved in the vasodilatory effect of simvastatin in aorta and small mesenteric artery of the rat. Br J Pharmacol 131: 1179-1187, 2000.
4. Baron R, Fourcade E, Lajoie-Mazenc I, Allai C, Couderc B, Barbaras R, Favre G, Faye J, Pradines A. RhoA prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidence in vivo by an anti-farnesyl cysteine antibody. Proc Natl Acad Sci USA 97: 11626-11631, 2000.
5. Biancani P, Walsh JH, Behar J. Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89: 867-874, 1985. (Pubitemid 15015305)
6. Chiba Y, Sato S, Hanazaki M, Sakai H, Misawa M. Inhibition of geranylgeranyltransferase inhibits bronchial smooth muscle hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol 297: L984-L991, 2009.
7. Collins EE, Lund JN. A review of chronic anal fissure management. Tech Coloproctol 11: 209-223, 2007. (Pubitemid 47459911)
8. De Godoy MAF, Rattan N, Rattan S. Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol 296: G727-G734, 2009.
9. De Godoy MAF, Rattan N, Rattan S. COX1 vs. COX-2 as a determinant of the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol 296: G219-G225, 2009.
10. De Godoy MAF, Rattan S. Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol 289: G1164-G1175, 2005. (Pubitemid 41740622)
11. Faust JR, Luskey KL, Chin DJ, Goldstein JL, Brown MS. Regulation of synthesis and degradation of 3-hydroxy-3-methlylgluataryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholestrol in UT-1 cells. Proc Natl Acad Sci USA 79: 5205-5209, 1982.
12. Fujihara H, Walker LA, Gong MC, Lemichez E, Bouquet P, Somlyo AV, Somlyo AP. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell 8: 2437-2447, 1997. (Pubitemid 27528212)
13. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 343: 425-430, 1990.
14. 2+ sensitization of rabbit smooth muscle. J Biol Chem 272: 10704-10709, 1997.
15. 2+ sensitization of smooth muscle. Proc Natl Acad Sci USA 93: 1340-1345, 1996.
16. Ito M, Nakano T, Erdodi F, Hartshorne DJ. Myosin phosphatase: structure, regulation and function. Mol Cell Biochem 259: 197-209, 2004. (Pubitemid 38519232)
17. Liu PY, Liao JK. A method for measuring Rho kinase activity in tissues and cells. Methods Enzymol 439: 181-189, 2008.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951.
19. Madoff RD, Fleshman JW. American gastroenterological association technical review on the diagnosis and treatment of hemorrhoids. Gastroenterology 126: 1463-1473, 2004. (Pubitemid 38552809)
20. Mills K, Chess-Williams R. Pharmacology of the internal anal sphincter and its relevance to faecal incontinence. Auton Autacoid Pharmacol 29: 85-95, 2009.
21. Murthy KS. Signaling for contraction and relaxation in smooth muscle of the gut. Annu Rev Physiol 68: 345-374, 2006.
22. O'Kelly TJ, Davies JR, Tam PK, Brading AF, Mortensen NJMC. Abnormalities of nitric-oxide-producing neurons in Hirschsprung's disease: Morphology and implications. J Ped Surg 29: 294-300, 1994.
23. Ohashi K, Osuga J, Tozawa R, Kitamine T, Yagyu H, Dikiya M, Tomita S, Okazaki H, Tamura Y, Yahagi N, Iizuka Y, Harada K, Gotoda T, Shimano H, Yamada N, Ishibashi S. Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem 278: 42936-42941, 2003. (Pubitemid 37345905)
24. Patel CA, Rattan S. Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol 291: G830-G837, 2006. (Pubitemid 44773679)
25. Patel CA, Rattan S. RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J Pharmacol Exp Ther 321: 501-508, 2007. (Pubitemid 46628593)
26. Perez-Guerrero C, Marquez-Martin A, Herrera MD, Marhuenda E, Alvarez de Sotomayor M. Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. Pharmacology 74: 209-215, 2005. (Pubitemid 41022583)
27. Rattan S. The internal anal sphincter: regulation of smooth muscle tone and relaxation. Neurogastroenterol Motil 17: 50-59, 2005. (Pubitemid 40756356)
28. Rattan S, Benjamin P, Maxwell IVPJ. RhoA/ROCK-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation. Gastroenterology 138: 13-18, 2010.
29. Rattan S, Chakder S. Role of nitric oxide as a mediator of internal anal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol 262: G107-G112, 1992.
30. Rattan S, De Godoy MAF, Patel CA. Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter. Gastroenterology 131: 108-116, 2006. (Pubitemid 44026500)
31. Rattan S, Regan RF, Patel CA, De Godoy MAF. Nitric oxide not carbon monoxide mediates nonadrenergic noncholinergic relaxation in the murine internal anal sphincter. Gastroenterology 129: 1954-1966, 2005.
32. Rikitake Y, Liao JK. Rho GTPases, statins, and nitric oxide. Circ Res 97: 1232-1235, 2005.
33. Sari R, Nemeth J, Porszasz R, Horvath P, Blasig IE, Ferdinandy P, Nagy I, Lonovics J, Szilvassy Z. Impairment by lovastatin of neural relaxation of the rabbit sphincter of Oddi. Eur J Pharmacol 432: 91-97, 2001. (Pubitemid 33153137)
34. Solski PA, Helms W, Keely PJ, Su L, Der CJ. RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification. Cell Growth Differ 13: 363-373, 2002.
35. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522: 177-185, 2000.
36. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
37. Sun J, Qian Y, Hamilton AD, Sebti SM. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth the nude mouse xenografts. Oncogene 16: 1467-1473, 1998. (Pubitemid 28151853)
38. Terzoli L, Mircoli L, Raco R, Ferrari AU. Lowering of elevated ambulatory blood pressure by HMG-CoA reductase inhibitors. J Cardiovasc Pharmacol 46: 310-315, 2005. (Pubitemid 41262833)
39. Yokoyama K, Gelb MH. Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzymegeranylgeranyl pyrophosphate complex. J Biol Chem 268: 4055-4060, 1993. (Pubitemid 23072941)
40. Zipp F, Waiczies S, Aktas O, Neuhaus O, Hemmer B, Schraven B, Nitsch R, Hartung HP. Impact of HMG-CoA reductase inhibition on brain pathology. Trends Pharmacol Sci 28: 342-349, 2007. (Pubitemid 47016681)