Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 4, 2009, Pages

  De Godoy, Márcio A F ^a   Rattan, Neeru ^a   Rattan, Satish ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Prostaglandin F2 ; Smooth muscle tone; Thromboxanes

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; LEUKOTRIENE C4; LIPOXIN A; MESSENGER RNA; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN F2 ALPHA; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL TISSUE; ANUS SPHINCTER; ARTICLE; CONTROLLED STUDY; MALE; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECTUM; SMOOTH MUSCLE; WESTERN BLOTTING; ANAL CANAL; ANIMAL; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANAL CANAL; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOXYGENASE INHIBITORS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 67149107136     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90707.2008     Document Type: Article

References (26)

1. Bellicini N, Molloy PJ, Caushaj P, Kozlowski P. Fecal incontinence - a review. Dig Dis Sci 53: 41-46, 2008.
2. Bharucha AE, Fletcher JG. Recent advances in assessing anorectal structure and functions. Gastroenterology 133: 1069-1074, 2007.
3. Biancani P, Walsh JH, Behar J. Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89: 867-874, 1985.
4. Borgeat P, Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 76: 32313-33217, 1979.
5. 2 in the maintenance of human lower esophageal sphincter tone. Gastroenterology 119: 243-252, 2000.
6. 2 and arachidonic acid metabolites in the maintenance of cat LES tone. Am J Physiol Gastrointest Liver Physiol 277: G585-G598, 1999.
7. Chan CC, Boyce C, Brideau S, Charleson W, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, Gordon R, Gresser M, Guay J, Kargman S, Kennedy B, Leblanc Y, Leger S, Mancini J, O'Neill GP, Ouellet M, Patrick D, Percival MD, Perrier H, Prasit P, Rodger I, Tagari P, Therien M, Vickers P, Visco D, Wang Z, Webb J, Wong E, Xu LJ, Young RN, Zamboni R, Riendeau D. Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2- (5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and Biochemical Profiles. J Pharmacol Exp Ther 290: 551-560, 1999.
8. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
9. 2 on some isolated smooth muscle preparations. Br J Pharmacol 73: 773-778, 1981.
10. 2 receptor associated with nitric-oxide synthase pathway. J Pharmacol Exp Ther 311: 394-401, 2004.
11. De Godoy MAF, Dunn SR, Rattan S. Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. Gastroenterology 127: 127-138, 2004.
12. De Godoy MAF, Rattan N, Rattan S. COX-1 vs. COX-2 as a determinant of the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol 296: G219-G225, 2009.
13. De Godoy MAF, Rattan S. Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol 289: G1164-G1175, 2005.
14. De Godoy MAF, Rattan S. Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats. J Pharmacol Exp Ther 318: 725-734, 2006.
15. 2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle. Am J Physiol Gastrointest Liver Physiol 293: G979-G986, 2007.
16. Evans JF, Ferguson AD, Mosley RT, Hutchinson JH. What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci 29: 72-78, 2008.
17. Goetzl EJ, Sun EF. Generation of uniquemono-hydroxy- eicosatetetraenoic acids from arachidonic acid by human neutrophils. J Exp Med 150: 406-411, 1979.
18. Grider JR. Neurotransmitters mediating the intestinal peristaltic reflex in the mouse. J Pharmacol Exp Ther 307: 460-467, 2003.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951.
20. 2: physiology/pathophysiology, cellular signal transduction and pharmacology. [Review]. Pharmacol Ther 118: 18-35, 2008.
21. Rattan S. The internal anal sphincter: regulation of smooth muscle tone and relaxation. Neurogastroenterol Motil 17: 50-59, 2005.
22. Roberts LJ Jr, Lewis RA, Oates JA, Austen KF. Prostaglandin, thromboxane, and 12-hydroxy-5,8,10,14-eicosatetranoic acid production by ionophore-stimulated rat serosal mast cells. Biochim Biophys Acta 575: 185-192, 1979.
23. Smith CJ, Zhang Y, Koboldt CM, Muhammad J, Zweifel BS, Shaffer A, Talley JJ, Masferrer JL, Seibert K, Isakson PC. Pharmacological analysis of cycloosygenase-1 in inflammation. Proc Natl Acad Sci USA 95: 13313-13318, 1998.
24. Soberman RJ, Austen KF. Kinetics of the arachidonic acid 5- and 15-lipoxygenases of the human polymorphonuclear leukocyte. Adv Prostaglandin Thromboxane Leukot Res 15: 169-171, 1985.
25. Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak MG, Malkowski MG, Garabito RM. Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid. J Biol Chem 276: 10343-10357, 2001.
26. Turini ME, DuBois RN. Cyclooxygenase-2: a therapeutic target. Annu Rev Med 53: 35-57, 2002.