Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent

European Journal of Pharmacology

Volumn 636, Issue 1-3, 2010, Pages 73-81

  Yan, Ling Di ^a   Liu, Yan Li ^a,b   Zhang, Lei ^c   Dong, Hua Jin ^a   Zhou, Pei Lan ^a   Su, Rui Bin ^a   Gong, Ze Hui ^a   Huang, Pei Tang ^d  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^d BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

Antinociception; Morphine; MVIIA; SO 3; Tolerance; Voltage sensitive calcium channel

Indexed keywords

ACETIC ACID; CALCIUM CHANNEL BLOCKING AGENT; FORMALDEHYDE; MORPHINE; OMEGA CONOTOXIN MVIIA; SO 3; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; FOOT PAIN; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; VISCERAL PAIN; WRITHING TEST;

ACETIC ACID; ANALGESICS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; DRUG INTERACTIONS; FORMALDEHYDE; INJECTIONS, SPINAL; LOCOMOTION; MALE; MICE; MORPHINE; NEURONS; OMEGA-CONOTOXINS; PAIN; RATS;

EID: 77952673557     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.03.036     Document Type: Article

References (34)

1. Bean P.P. Classes of calcium channel in vertebrate cell. Annu. Rev. Physiol. 1989, 51:367-384.
2. Bourinet E., Soong T.W., Stea A., Snutch T.P. Determinants of the G protein dependent opioid modulation of neuronal calcium channels. Proc. Natl Acad. Sci. U. S. A. 1996, 93:1486-1491.
3. Bowersox S.S., Gadbois T., Singh T., Pettus M., Wang Y.X., Luther R.R. Selective N-type neuronal voltage-sensitive calcium channelblocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain. J. Pharmacol. Exp. Ther. 1996, 279(3):1243-1249.
4. Cizkova D., Marsala J., Lukacova N., Marsala M., Jergova S., Orendacova J., Yaksh T.L. Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp. Brain Res. 2002, 147:456-463.
5. Collier H.O., Dinneen L.C., Johnson C.A., Scheider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. Chemother. 1968, 32:295-310.
6. Cowan A., Porreca F., Wheeler H. Use of the formalin test in evaluating analgesics. NIDA Res. Monogr. 1989, 95:116-122.
7. Dai Q., Liu F., Zhou Y., Lu B., Yu F., Huang P.T. The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. J. Nat. Prod. 2003, 66(9):1276-1279.
8. De Waard M., Liu H., Walker D., Scott V.E., Gurnett C.A., Campbell K.P. Direct binding of G-protein betagamma complex to voltage-dependent calcium channels. Nature 1997, 385:446-450.
9. Dubuission D., Dennis S.G. The formalin tests: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats. Pain 1977, 4:161-174.
10. Hylden J.L., Wilcox G.L. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 1980, 67:313-316.
11. Law P.Y., Wong Y.H., Loh H.H. Molecular mechanisms and regulation of opioid receptor signaling. Annu. Rev. Pharmacol. Toxicol. 2000, 40:389-430.
12. Lu B.S., Yu F., Zhao D., Huang P.T., Huang C.F. Conopeptides from Conus striatus and Conus textile by cDNA cloning. Peptides 1999, 20:1139-1144.
13. Malmberg A.B., Yaksh T.L. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 1992, 263:136-146.
14. Malmberg A.B., Yaksh T.L. Effect of continuous intrathecal infusion of u-conopeptides, N-type calcium channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 1995, 60:83-90.
15. Miljanich G.P., Ramachandran J. Antagonists of neuronal calcium channels: structure, function, and therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 1995, 35:707-734.
16. Olivera B.M., Miljanich G.P., Ramachandran J., Adams M.E. Calcium channel diversity and neurotransmitter release: the v-conotoxins and v-agatoxins. Annu. Rev. Biochem. 1994, 63:823-867.
17. Omote K., Kawamata M., Satoh O., Iwasaki H. Spinal antinociceptive action of an N-type voltage-dependent calcium channel blocker and the synergistic interaction with morphine. Anesthesiology 1996, 84:636-643.
18. Ray S.B., Gupta H., Gupta Y.K. Up-regulation of μ-opioid receptors in the spinal cord of morphine-tolerant rats. J. Biosci. 2004, 29:51-56.
19. Ruskin K.I., Moises H.C. mu-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons. J. Neurosci. 1995, 15:4315-4327.
20. Scott D.A., Wright C.E., Angus J.A. Actions of intrathecal N-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur. J. Pharmacol. 2002, 451:279-286.
21. Seward E., Hammond C., Henderson G. Mu-opioid-receptor-mediated inhibition of the N-type calcium-channel current. Proc. R. Soc. Lond. B Biol. Sci. 1991, 244:129-135.
22. Starkson R.V., Kjplrsvik A., Tjdsen A., Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J. Neurosci. Methods 1996, 65:167-172.
23. Toth P.T., Shekter L.R., Ma G.H., Philipson L.H., Miller R.J. Selective G-protein regulation of neuronal calcium channels. J. Neurosci. 1996, 16:4617-4624.
24. Vanegas H., Schaible H.G. Effects of antagonists to highthreshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain 2000, 85:9-18.
25. Verma D., Gupta Y.K., Parashar A., Ray S.B. Differential expression of L- and N-type voltage-sensitive calcium channels in the spinal cord of morphine+nimodipine treated rats. Brain Res. 2009, 1249:128-134.
26. Wallace M.S., Kosek P.S., Staats P., Fisher R., Schultz D.M., Leong M. Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain. Pain Med. 2008, 9(3):271-281.
27. Wang Y.X., Pettus M., Gao D., Phillips C., Bowersox S.S. Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain. Pain 2000, 84:151-158.
28. Wang Y.X., Gao D., Pettus M., Phillips C., Bowersox S.S. Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain 2000, 84:271-281.
29. Webster L.R., Fisher R., Charapata S., Wallace M.S. Long-term intrathecal ziconotide for chronic pain: an open-label study. J. Pain Symptom Manage. 2009, 37(3):363-372.
30. Wen L., Yang S., Qiao H., Liu Z., Zhou W., Zhang Y., Huang P.T. SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br. J. Pharmacol. 2005, 145(6):728-739.
31. Westenbroek R.E., Hell J.W., Warner C., Dubel S.J., Snutch T.P., Catterall W. Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron 1992, 6:1099-1115.
32. 2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals. J. Neurosci. 1998, 18:6319-6330.
33. Yan Y.B., Tu G.Z., Luo X.C., Dai Q.Y., Huang P.T., Zhang R.Q. Three dimensional solution structure of omega-conotoxin SO-3 determined by NMR. Chin. Sci. Bull. 2003, 48:1097-1102.
34. 2+ channels support their inhibition by G proteins. Neuron 1996, 17:991-1003.