Obaculactone suppresses Th1 effector cell function through down-regulation of T-bet and prolongs skin graft survival in mice

Biochemical Pharmacology

Volumn 80, Issue 2, 2010, Pages 218-225

  Gong, Fangyuan ^a   Shen, Yan ^a   Zhang, Qi ^a   Sun, Yang ^a   Tang, Jiayu ^a   Tao, Feifei ^a   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Allorejection; Obaculactone; T bet; Th1 effector cell; Treg cell

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; CYCLOSPORIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; NATURAL PRODUCT; OBACULACTONE; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CITRUS FRUIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN GRAFT; SPLEEN CELL; TH1 CELL; UPREGULATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GRAFT SURVIVAL; INTERFERON-GAMMA; LIMONINS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLANT EXTRACTS; RECEPTORS, IGG; SKIN TRANSPLANTATION; SPLEEN; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 77952672910     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.03.028     Document Type: Article

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