Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer

Prostate

Volumn 68, Issue 4, 2008, Pages 418-426

  Liu, Jun Wei ^a   Nagpal, Jatin K ^a   Jeronimo, Carmen ^b   Ji, Eun Lee ^a   Henrique, Rui ^b   Myoung, Sook Kim ^a   Ostrow, Kimberly L ^a   Yamashita, Keishi ^a   Van Criekinge, Vim ^c   Wu, Guojun ^d   Moon, Chu So ^a   Trink, Barry ^a   Sidransky, David ^a,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^c OncoMethylome Sciences SA   (Belgium)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Biomarker; MCAM; Methylation; Prostate cancer

Indexed keywords

BISULFITE; CD146 ANTIGEN; GENOMIC DNA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER STAGING; COLONY FORMATION; DNA METHYLATION; GLEASON SCORE; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; PROSTATIC INTRAEPITHELIAL NEOPLASIA;

ADULT; AGED; ANTIGENS, CD146; BASE SEQUENCE; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC SCREENING; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROSTATE; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 40349103522     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20709     Document Type: Article

References (27)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J Clin 2007;57:43-66.
2. Nelson WG, De Marzo AM, Isaacs WB, Prostate cancer. N Engl J Med 2003;349:366-381.
3. Frankel S, Smith GD, Donovan J, Neal D, Screening for prostate cancer. Lancet 2003;361:1122-1128.
4. Sidransky D, Emerging molecular markers of cancer. Nat Rev Cancer 2002;2:210-219.
5. Ushijima T, Detection and interpretation of altered methylation patterns in cancer cells. Nat Rev Cancer 2005;5:223-231.
6. Li LC, Carroll PR, Dahiya R, Epigenetic changes in prostate cancer: Implication for diagnosis and treatment. J Natl Cancer Inst 2005;97:103-115.
7. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D, 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;1:686-692.
8. Jeronimo C, Usadel H, Henrique R, Oliveira J, Lopes C, Nelson WG, Sidransky D, Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma. J Natl Cancer Inst 2001;93:1747-1752.
9. Jeronimo C, Henrique R, Hoque MO, Mambo E, Ribeiro FR, Varzim G, Oliveira J, Teixeira MR, Lopes C, Sidransky D, A quantitative promoter methylation profile of prostate cancer. Clin Cancer Res 2004;10:8472-8478.
10. Yegnasubramanian S, Kowalski J, Gonzalgo ML, Zahurak M, Piantadosi S, Walsh PC, Bova GS, De Marzo AM, Isaacs WB, Nelson WG, Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res 2004;64:1975-1986.
11. Kang GH, Lee S, Lee HJ, Hwang KS, Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia. J Pathol 2004;202:233-240.
12. Sers C, Kirsch K, Rothbacher U, Riethmuller G, Johnson JP, Genomic organization of the melanoma-associated glycoprotein MU C18: Implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci USA 1993;90:8514-8518.
13. Shih IM, Elder DE, Speicher D, Johnson JP, Herlyn M, Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res 1994;54:2514-2520.
14. Denton KJ, Stretch JR, Gatter KC, Harris AL, A study of adhesion molecules as markers of progression in malignant melanoma. J Pathol 1992;167:187-191.
15. Kraus A, Masat L, Johnson JP, Analysis of the expression of intercellular adhesion molecule-1 and MUC18 on benign and malignant melanocytic lesions using monoclonal antibodies directed against distinct epitopes and recognizing denatured, non-glycosylated antigen. Melanoma Res 1997;7 (Suppl 2):S75-S81.
16. Hoque MO, Kim MS, Ostro KL, Liu J, Wisman GBA, Jeronimo C, Henerique R, Lendvai Á, Schuuring E, Straub J, Park HL, Poeta L, Begum S, Rosenbaum E, Yamashita K, Califano J, Westra W, van der Zee AGJ, Van Criekinge W, Sidransky D, Genome-wide promoter analysis uncovers portions of the cancer "Methylome" in primary tumors and cell lines. Cancer Res (in press).
17. Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D, Inverse correlation between cyclin A1 hypermethylation and p53
18. mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res 2004;64:5982-5987.
19. Liu JW, Kim MS, Nagpal J, Yamashita K, Poeta L, Chang X, Lee J, Park HL, Jeronimo C, Westra WH, Mori M, Moon CS, Trink B, Quantitative hypermethylation of NMDAR2B in human gastric cancer. Int J Cancer 2007;121:1994-2000.
20. Lehmann JM, Riethmuller G, Johnson JP, MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci USA 1989;86:9891-9895.
21. Xie S, Luca M, Huang S, Gutman M, Reich R, Johnson JP, Bar-Eli M, Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res 1997;57:2295-2303.
22. Wu GJ, Varma VA, Wu MW, Wang SW, Qu P, Yang H, Petros JA, Lim SD, Amin MB, Expression of a human cell adhesion molecule, MUC18, in prostate cancer cell lines and tissues. Prostate 2001;48:305-315.
23. Wu GJ, Peng Q, Fu P, Wang SW, Chiang CF, Dillehay DL, Wu MW, Ectopical expression of human MUC18 increases metastasis of human prostate cancer cells. Gene 2004;327:201-213.
24. Jean D, Gershenwald JE, Huang S, Luca M, Hudson MJ, Tainsky MA, Bar-Eli M, Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells. J Biol Chem 1998;273:16501-16508.
25. Mintz-Weber CS, Johnson JP, Identification of the elements regulating the expression of the cell adhesion molecule MCAM/M UC18. Loss of AP-2 is not required for MCAM expression in melanoma cell lines. J Biol Chem 2000;275:34672-34680.
26. Guess HA, Benign prostatic hyperplasia and prostate cancer. Epidemiol Rev 2001;23:152-158.
27. Leav I, McNeal JE, Ho SM, Jiang Z, Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. Hum Pathol 2003;34:228-233.