Uridine adenosine tetraphosphate: A novel endothelium-derived vasoconstrictive factor

Nature Medicine

Volumn 11, Issue 2, 2005, Pages 223-227

  Jankowski, Vera ^a   Tölle, Markus ^a   Vanholder, Raymond ^b   Schönfelder, Gilbert ^a   Van Der Giet, Markus ^a   Henning, Lars ^a   Schlüter, Hartmut ^a   Paul, Martin ^a   Zidek, Walter ^a   Jankowski, Joachim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; CALCIMYCIN; ENDOTHELIN; ENDOTHELIUM DERIVED CONSTRICTING FACTOR; NITRIC OXIDE; PURINE P2X1 RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y4 RECEPTOR; UNCLASSIFIED DRUG; URIDINE ADENOSINE TETRAPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR AUTOREGULATION; CELL STIMULATION; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY PERFUSION; MASS SPECTROMETRY; MECHANICAL STRESS; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; SKIN BLOOD VESSEL; SUPERNATANT; VASOCONSTRICTION;

ADENINE NUCLEOTIDES; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; KIDNEY; MASS SPECTROMETRY; MOLECULAR WEIGHT; RATS; URACIL NUCLEOTIDES; VASOCONSTRICTOR AGENTS;

EID: 20044365597     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1188     Document Type: Article

References (22)

1. Palmer, R.M., Ferrige, A.G. & Moncada, S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526 (1987).
2. Jankowski, J., Potthoff, W., Zidek, W. & Schlüter, H. Purification of chemically synthesised dinucleoside(5′,5′) polyphosphates by displacement chromatography. J. Chromatogr. B. Biomed. Sci. Appl. 719, 63-70 (1998).
3. Kasakov, L. & Burnstock, G. The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur. J. Pharmacol. 86, 291-294 (1982).
4. Bo, X., Sexton, A., Xiang, Z., Nori, S.L. & Burnstock, G. Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels. Eur. J. Pharmacol. 353, 59-65 (1998).
5. Kunapuli, S.P. & Daniel, J.L. P2 receptor subtypes in the cardiovascular system. Biochem. J. 336, 513-523 (1998).
6. Wang, L. et al. P2 receptor expression profiles in human vascular smooth muscle and endothelial cells. J. Cardiovasc. Pharmacol. 40. 841-853 (2002).
7. Pulvirenti, T.J. et al. P2X (purinergic) receptor redistribution in rabbit aorta following injury to endothelial cells and cholesterol feeding, J. Neurocytol. 29, 623-631 (2000).
8. Nori, S., Fumagalli, L., Bo, X., Bogdanov, Y. & Burnstock, G. Coexpression of mRNAs for P2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situ hybridization and RT-PCR study. J. Vasc. Res. 35, 179-185 (1998).
9. Turner, C.M., Vonend, O., Chan, C., Burnstock, G. & Unwin, R.J. The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Cells Tissues Organs 175, 105-117 (2003).
10. North, R.A. Molecular physiology of P2X receptors. Physiol. Rev. 82, 1013-1067 (2002).
11. 5I) is a potent antagonist at recombinant rat P2X1 receptors. Br. J. Pharmacol. 128, 981-988 (1999).
12. Lewis, C.J., Surprenant, A. & Evans, R.J. 2′,3-0-(2,4,6- trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)-a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br. J. Pharmacol. 124, 1463-1466 (1998).
13. Honore, P. et al. TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain 96, 99-105 (2002).
14. Vial, C. & Evans, R.J. P2X(1) receptor-deficient mice establish the native P2X receptor and a P2Y6-like receptor in arteries. Mol. Pharmacol. 62, 1438-1445 (2002).
15. Burnstock, G. Purinergic signaling and vascular cell proliferation and death. Arterioscler. Thromb. Vasc. Biol. 22, 364-373 (2002).
16. Burnstock, G. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J. Anat. 194, 335-342 (1999).
17. Gorman, M.W., Marble, D.R., Ogimoto, K. & Feigl, E.O. Measurement of adenine nucleotides in plasma. Luminescence 18, 173-181 (2003).
18. Lazarowski, E.R. & Boucher, R.C. UTP as an extracellular signaling molecule. News Physiol. Sci. 16, 1-5 (2001).
19. Traut, T.W. Physiological concentrations of purines and pyrimidines. Mol. Cell. Biochem. 140, 1-22 (1994).
20. van der Giet, M. et al. The critical role of adenosine and guanosine in the affinity of dinucleoside polyphosphates to P(2x)-receptors in the isolated perfused rat kidney. Br. J. Pharmacol. 132, 467-474 (2001).
21. Barnes, L.D., Robinson, A.K., Mumford, C.H. & Garrison, P.N. Assay of diadenosine tetraphosphate hydrolytic enzymes by boronate chromatography. Anal. Biochem. 144, 296-304 (1985).
22. Nofer, J.R. et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J. Clin. Invest. 113, 569-581 (2004).