Characterization of immune-active peptides obtained from milk fermented by Lactobacillus helveticus

Journal of Dairy Research

Volumn 77, Issue 2, 2010, Pages 129-136

  Tellez, Angela ^a   Corredig, Milena ^a   Brovko, Lubov Y ^a   Griffiths, Mansel W ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Bioactive peptides; Fermented milk; Immunomodulation; Macrophages

Indexed keywords

CASEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTALBUMIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; DAIRY PRODUCT; DRUG EFFECT; HYDROLYSIS; IMMUNOLOGY; IMMUNOMODULATION; LACTOBACILLUS HELVETICUS; MACROPHAGE; METABOLISM; MICROBIOLOGY; MOUSE; PHAGOCYTOSIS;

ANIMALS; CASEINS; CELLS, CULTURED; CULTURED MILK PRODUCTS; HYDROLYSIS; IMMUNOMODULATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LACTALBUMIN; LACTOBACILLUS HELVETICUS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PEPTIDES; PHAGOCYTOSIS; TUMOR NECROSIS FACTOR-ALPHA;

LACTOBACILLUS HELVETICUS; MURINAE;

EID: 77952548627     PISSN: 00220299     EISSN: 14697629     Source Type: Journal    
DOI: 10.1017/S002202990999046X     Document Type: Article

References (37)

1. Abbas AK, Lichtman AH & Pobe JS 1994 Cytokines: Cellular and Molecular Immunology. 2nd Edition. W.B. Sanders Co., pp. 240. Philadelphia PA, USA
2. Aderem A & Underhill DM 1999 Mechanisms of Phagocytosis in Macrophages. Annual Reviews of Immunology 17 593-623
3. Brovko L, Vandenende C, Chu B, NG K, Brooks A & Griffiths MW 2003 In Vivo Assessment of Effect of Fermented Milk Diet on Course of Infection in Mice with Bioluminescent Salmonella. Journal of Food Protection 66 2160-2163
4. S1-Casein(f1-9) and β-Casein(f193-209) by Lactobacillus helveticus Peptidase Deletion Mutants Indicates the Presence of a Previously Undetected Endopeptidase. Environmental Microbiology 69 1283-1286
5. Coste M, Rochet V, Lonil J, Molle D, Bouhallab S & Tome D 1992 Identification of C-terminal peptides of bovine//-casein that enhance proliferation of rat lymphocytes. Immunology Letters 33 41-46
6. De LeBlanc A, Matar C, LeBlanc N & Perdigon G 2005 Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model. Breast Cancer Research 7 477-486
7. De LeBlanc A, Chaves S, Carmuega E, Weill R, Antoine J & Perdigon G 2008 Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages. Immunobiology 213 97-108
8. de Moreno de LeBlanc A, Chaves S, Carmuega E, Weill R, Antoine J & Perdigon G 2008 Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages. Immunobiology 213 97-108
9. Deutsch S, Molle D, Gagnaire V, Piot M, Atlan D & Lortal S 2000 Hydrolysis of Sequenced β-Casein Peptides Provides New Insight into Peptidase Activity from Thermophilic Lactic Acid Bacteria and Highlights Intrinsic Resistance of Phosphopeptides. Applied and Environmental Microbiology 66 5360-5367
10. FitzGerald RJ & Meisel H 2003 Milk protein hydrolysates and bioactive peptides. In PF Fox and PLH McSweeney (eds). Advanced dairy chemistry, Vol. 1: Proteins. 3rd Edition. New York, NY, USA: Kluwer Academic
11. Gasteiger E, Hoogland C, Gattiker A, Duvaud S, Wilkins MR, Appel RD & Bairoch A 2005 In JM Walker (eds). Protein Identification and Analysis Tools on the ExPASy Server. Totowa, NJ, USA: Humana Press Inc.
12. Herbert E, Rayas R & de Giori G 1997 Characterization of a Cell Membrane-Associated Proteinase from Lactobacillus helveticus CRL 581. Current Microbiology 35 161-164
13. Jeffrey B, Van Ostade X & Lopez A 1996 Tumour necrosis factor-alpha (TNF-α): The good, the bad and potentially very effective. Immunology and Cell Biology 74 434-443
14. Jolles P & Migliore-Samour D 1988 Casein, a prohormone with an immunomodulasting role for the newborn? Cellular and Molecular Life Science 44 188-193
15. Kagan A, Yu Z, Fishman G & McDonald T 2000 The Dominant Negative LQT2 Mutation A561V Reduces Wild-type HERG Expression. The Journal of Biological Chemistry 275 11241-11248
16. Kenny O, FitzGerald RJ, O'Cuinn G, Beresford T & Jordan K 2003 Growth phase and growth medium effects on the peptidase activities of Lactobacillus helveticus. International Dairy Journal 13 509-516
17. LeBlanc JG, Matar C, Valdez JC, LeBlanc J & Perdigon G 2002 Immunomodulating Effects of Peptidic Fractions Issued from Milk Fermented with Lactobacillus helveticus. Journal of Dairy Science 85 2733-2742
18. LeBlanc J, Fliss I & Matar C 2004 Induction of a Humoral Immune Response following an Escherichia coli O157:H7 Infection with an Immunomodulatory Peptidic Fraction Derived from Lactobacillus helveticus-Fermented Milk. Clinical and Diagnostic Laboratory Immunology 11 1171-1181
19. Matar C, Valdez JC, Medina M, Rachid M & Perdigon G 2001 Immunomodulating effects of milks fermented by Lactobacillus helveticus and its non-proteolytic variant. Journal of Dairy Research 68 601-609
20. Matar C, LeBlanc JG, Martin L & Perdigon G 2003 Biologically active peptides released from fermented milk: role and functions, In ER Farnworth (eds), Handbook of fermented functional foods. 1rst Edition. Boca Raton, FL, USA: CRC Press
21. Meisel H & Bockelmann W 1999 Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties. Antoine van Leeuwenhoek 76 207-315
22. Miettinen M, Vuopio-varkila J & Varkila K 1996 Production of Human Tumor Necrosis Factor Alpha, Interleukin-6 and Interleukin-10 is induced by Lactic Acid Bacteria. Infection and Immunity 64 5403-5405
23. Netea MG, van der Meer J, van Deuren M & Kullberg B 2003 Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends in Immunology 24 254-258
24. Ng KY & Grifffiths MW 2002 Enhancement of macrophage cytokine release by cell-free fractions o fermented milk. Milchwissenschaft 57 66-70
25. Parker D, Migliore-Samour D, Floch F, Zerial A, Werner G, Jolles J, Casaretto M, Zahn H & Jolles P 1984 Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties. European Journal of Biochemistry 45 677-682
26. Perdigon G, Fuller R & Rayas R 2001 Lactic Acid Bacteria and their Effect on the Immune System. Current issues in intestinal microbiology 2 27-42
27. Perkins D, Pappin D, Creasy D & Cottrell J 1999 Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20 3551-3567
28. Sandre C, Gleizes A, Foresties F, Gorges-Kergot R, Chilmonczyk S, Leonil J, Moreau MC & Labarre C 2001 A Peptide Derived from Bovine b-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice. The Journal of Nutrition 131 2936-2942
29. Takahashi T, Oka T, Iwana H, Kuwata T & Yamamoto Y 1993 Immune response of mice to orally administered lactic acid bacteria. Bioscience, biotechnology, and biochemistry 57 1557-1560
30. Tejada-Simon MV & Pestka J 1999 Proinflamatory cytokine and nitric oxide induction in murine macrophages by cell wall and cytoplasmic extracs of Lactic acid bacteria. Journal of Food Protection 62 1435-1444
31. Tsao L, Lin Ch & Wang J 2004 Justicidin A Inhibits the Transport of Tumor Necrosis Factor-α to Cell Surface in Lipopolysaccharide-Stimulated RAW 264·7 Macrophages. Molecular pharmacology 65 1063-1069
32. Urban J, Shepard HM, Rothstein JL, Sugarman BJ & Schreiber H 1986 Tumor necrosis factor: A potent effector molecule for tumor cell killing by activated macrophages. Immunology 83 5233-5237
33. Ustundag B, Yilmaz E, Dogan Y, Akarsu S, Canatan H, Halifeoglu I, Cikim G & Aygun D 2005 Levels of Cytokines (IL-1β, IL-2, IL-6, IL-8, TNF-α) and Trace Elements (Zn, Cu) in Breast Milk From Mothers of Preterm and Term Infants. Mediators of Inflammation 6 331-336
34. Vinderola G, Matar C & Perdigon G 2007a Milk fermentation products of L. helveticus R389 activate calcineurin as a signal to promote gut mucosal immunity. Immunology 8 1-10
35. Vinderola G, Matar C, Palacios J & Perdigon G 2007b Mucosal immunomodulation by the non-bacterial fraction of milk fermented by L. Helveticus R389. International Journal of Food Microbiology 115 180-186 (Pubitemid 46367331)
36. Vinderola G, Matar C & Perdigon G 2007c Milk fermented by Lactobacillus helveticus R389 and its non-bacterial fraction confer enhanced protection against Salmonella enteritidis serovar Typhimurium infection in mice. Immunobiology 212 107-118
37. Yasutaka A & Kiyoshi O 2002 Endomorphin-2 Modulates Productions of TNF-α, IL-1β, IL-10, and IL-12, and Alters Functions Related to Innate Immune of Macrophages. Inflammation 26 223-232