The role of tubulointerstitial inflammation in the progression of chronic renal failure

Nephron - Clinical Practice

Volumn 116, Issue 2, 2010, Pages

  Rodríguez Iturbe, Bernardo ^a,c   García García, Guillermo ^b  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

^b UNIVERSITY OF GUADALAJARA   (Mexico)

^c HOSPITAL UNIVERSITARIO DE MARACAIBO   (Venezuela)

Author keywords

Atubular glomeruli; Chronic kidney disease; Inflammatory cells; Oxidative stress; Proteinuria; Vitamin D

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; CELL ADHESION MOLECULE; CHEMOKINE; COLLAGEN; COMPLEMENTARY RNA; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERYTHROPOIETIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MELATONIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NICOTINIC ACID; NITRIC OXIDE DONOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PYRROLIDINE DITHIOCARBAMATE; RAPAMYCIN; SILDENAFIL; TRANSFORMING GROWTH FACTOR BETA; VITAMIN D DERIVATIVE;

AUTOREGULATION; CELL INFILTRATION; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY FAILURE; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE COURSE; DNA IMMUNIZATION; DRUG TOXICITY; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE REGULATORY NETWORK; GLOMERULOSCLEROSIS; HUMAN; HYPOXIA; INFLAMMATORY CELL; INTERSTITIAL NEPHRITIS; KIDNEY BLOOD FLOW; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY POLYCYSTIC DISEASE; KIDNEY SCAR; KIDNEY TUBULE CELL; MYOFIBROBLAST; NEPHROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; SHORT SURVEY; SIGNAL TRANSDUCTION; URETER OBSTRUCTION; VITAMIN D DEFICIENCY;

ANIMALS; DISEASE PROGRESSION; HUMANS; INFLAMMATION; KIDNEY FAILURE, CHRONIC; KIDNEY TUBULES; NEPHRITIS, INTERSTITIAL; OXIDATIVE STRESS; PROTEINURIA;

EID: 77952477767     PISSN: 16602110     EISSN: None     Source Type: Journal    
DOI: 10.1159/000314656     Document Type: Short Survey

References (43)

1. Risdon RA, Sloper JC, de Wardener HE: Re-lationship between renal function and his-tological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968; 2: 363-366.
2. Bohle A, Mackensen-Haen S, von Gise H, Grund KE, Wehrmann M, Batz C, Bogen-schütz O, Schmitt H, Nagy J, Müller C, Mül-ler G: The consequences of tubulo-interstitial changes for renal function in glomerulopa-thies. A morphometric and cytological anal-ysis. Pathol Res Pract 1990; 186: 135-144.
3. Rodríguez-Iturbe B, Pons H, Herrera-Acosta J, Johnson RJ: The role of immunocompetent cells in non-immune renal diseases. Kidney Int 2001; 59: 1626-1640.
4. Rodriguez-Iturbe B, Johnson RJ, Herrera-Acosta J: Tubulointerstitial damage and pro-gression of renal failure. Kidney Int 2005; 68(suppl 99):S82-S86.
5. Lin SL, Kisseleva T, Brenner DA, Duffield JS: Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
6. Iwano M, Plieth D, Danoff TM, Xue C, Oka-da H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibro-sis. J Clin Invest 2002; 110: 341-350.
7. Tan TK, Zheng G, Hsu TT, Wang Y, Lee VW, Tian X, Wang Y, Cao Q, Wang Y, Harris DC: Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells. Am J Pathol 2010, E-pub ahead of print.
8. Liu Y: Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 2006; 69:213-217.
9. Kriz W, LeHir M: Pathways to nephron loss starting from glomerular diseases: insights from animal models. Kidney Int 2005; 67: 404-419.
10. Benigni A, Gagliardini E, Remuzzi A, Coma D, Remuzzi G: Angiotensin-converting en-zyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Hey-man nephritis, an effect not observed with a calcium antagonist. Am J Pathol 2001; 159: 1743-1750.
11. Gandhi M, Olson JL, Meyer TW: Contribu-tion of tubular injury to loss of remnant kid-ney function. Kidney Int 1998; 54:1157-1165.
12. Fine LG, Norman JT: Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeu-tics. Kidney Int 2008; 74:867-872.
13. Nangaku M: Chronic hypoxia and tubuloin-terstitial injury: a final common pathway to end stage renal failure. J Am Soc Nephrol 2006; 17:17-25.
14. Eddy A A: Progression in chronic kidney dis-ease. Adv Chronic Kidney Dis 2005; 12: 353-365.
15. Miyata T, de Strihou CY: Diabetic nephropa-thy: a disorder of oxygen metabolism? Nat Rev Nephrol 2009; 6:1-13.
16. Bidani AK, Griffin KA: Pathophysiology of hypertensive renal damage: implications for therapy. Hypertension 2004; 44: 595-601.
17. Salmond R, Seney FD: Reset tubuloglomeru-lar feedback permits and sustains glomeru-lar hyperfunction after extensive renal abla-tion. Am J Physiol 1991; 260:F395-F401.
18. Sánchez-Lozada G, Tapia E, Johnson RJ, Ro-driguez-Iturbe B, Herrera-Acosta J: Glomer-ular hemodynamic changes associated with arteriolar lesions and tubulointerstitial in-flammation. Kidney Int 2003; 64(suppl 86): S9-S14.
19. Touyz RM, He G, El Mabroul M, Schiffrin EL: p38 MAP kinase regulates vascular smooth muscle cell collagen synthesis by an-giotensin II in SHR but not in WKY. Hypertension 2001; 37: 574-580.
20. Sharma K, Cook A, Smith M, Valancius C, Inscho EW: TGF-beta impairs renal autoreg-ulation via generation of ROS. Am J Physiol Renal Physiol 2005; 288:F1069-F1077.
21. Alvarez V, Quiroz Y, Nava M, Pons H, Rodri-guez-Iturbe B: Overload proteinuria is fol-lowed by salt-sensitive hypertension caused by renal infiltration of immune cells. Am J Physiol Renal Physiol 2002; 283:F1132-F1141.
22. Remuzzi G: Nephropathic nature of protein-uria. Curr Opin Nephrol Hypertens 1999; 8: 655-663.
23. DAmico G, Bazzi C: Pathophysiology of pro-teinuria. Kidney Int 2003; 63: 809-825.
24. Iseki K, Ikemiya Y, Iseki C, Takishita S: Pro-teinuria and the risk of developing end-stage renal disease. Kidney Int 2003; 63:1468-1474. (Pubitemid 36350012)
25. Nakajima H, Takenaka M, Kaimori JY, Na-gasawa Y, Kosugi A, Kawamoto S, Imai E, Hori M, Okubo K: Gene expression profile of renal proximal tubules regulated by protein-uria. Kidney Int 2002; 61:1577-1587.
26. Biemesderfer D: Regulated intramembrane proteolysis of megalin: linking urinary pro-tein and gene regulation in proximal tubule? Kidney Int 2006; 69:1717-1721.
27. Morigi M, Macconi D, Zoja C, Donadelli R Buelli S, Zanchi C, Ghilardi M, Remuzzi G: Protein overload-induced NF-κB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway. J Am Soc Nephrol 2002;13: 1179-1189.
28. Takase O, Hirahashi J, Takayanagi A, Chi-karaishi A, Marumo T, Ozawa Y, Hayashi M, Shimizu N Saruta T: Gene transfer of trun-cated IκBα prevents tubulointerstitial injury. Kidney Int 2003; 63:501-513.
29. Anders HJ, Ninichuk V, Schöndorff D: Pro-gression of kidney disease: blocking leuko-cyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int 2006; 69:29-32.
30. He C, Imai M, Song H, Quigg RJ, Tomlinson S: Complement inhibitors targeted to the proximal tubule prevent injury in experi-mental nephritic syndrome and demonstrate a key role for C5b-9. J Immunol 2005; 174: 5750-5757.
31. Noris M, Morigi M, Remuzzi B: Comple-ment-mediated dysfunction of glomerular filtration barrier accelerates progressive re-nal injury. J Am Soc Nephrol 2008; 19: 1158-1167.
32. Van Timmeren MM, Bakker SJ, Stegeman CA, Gans RO, van Goor H: Addition of oleic acid to delipidated bovine serum albumin aggravates renal damage in experimental protein-overload nephrosis. Nephrol Dial Transplant 2005; 20:2349-2357.
33. Arici M, Chana R, Lewington A, Brown J, Brunskill NJ: Stimulation of proximal tubu-lar cell apoptosis by albumin-bound fatty ac-ids mediated by peroxisome proliferator ac-tivated receptor-7. J Am Soc Nephrol 2003; 14:17-27.
34. Morais C, Westhuyzen J, Metharom P, Healy H: High molecular weight plasma proteins induce apoptosis and Fas/FasL expression in human proximal tubular cells. Nephrol Dial Transplant 2005; 20:50-58.
35. Tejera N, Gomez-Garre D, Lazaro A, Ga-llego-Delgado J, Alonso C, Blanco J, Ortiz A, Egido J: Persistent proteinuria up-regulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells. Am J Pathol 2004; 164:1817-1826.
36. Macconi D, Chiabrando C, Schiarea S, Aiello S, Cassis L, Gagliardini E, Noris M, Buelli S, Zoja C, Corna D, Mele C, Fanel li R, Remuzzi G, Benigni A: Proteasomal processing of al-bumin by renal dendritic cells generates an-tigenic peptides. J Am Soc Nephrol 2009; 20: 123-130.
37. 3 and the synthetic vitamin D analogue, KH 1060, modulate the growth of mouse proximal tubular cells. Kidney Blood Press Res 1996; 19: 325-331.
38. 3 inhibits renal in-terstitial myofibroblast activation by induc-ing hepatocyte growth factor expression. Kidney Int 2005; 68:1500-1510.
39. Aschenbrenner JK, Sollinger HW, Becker BN, Hullet DA: 1,25-(OH) 2 D 3 alters the transforming growth factor ß signaling pathway in renal tissue. J Surg Res 2001; 100: 171-175.
40. Tan X, He W, Liu Y: Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int 2009; 76:1248-1257.
41. Freundlich M, Quiroz Y, Zhang Z, Zhang Y, Bravo Y, Weisinger JR, Li YC, Rodriguez-Iturbe B: Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int 2008; 74: 1394-1402.
42. Kikuchi H, Kawachi H, Ito Y, et al: Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltra-tion in rats but not progressive interstitial fi-brosis. Nephrol Dial Transplant 2000; 15: 799-810
43. 12 malabsorption. Pediatr Nephrol 2003; 18: 417-421.