Neuromedin S: Discovery and functions

Results and Problems in Cell Differentiation

Volumn 46, Issue , 2008, Pages 201-212

  Mori, Kenji ^a   Miyazato, Mikiya ^a   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; NEUROMEDIN S; NEUROMEDIN U; NEUROPEPTIDE; PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CIRCADIAN RHYTHM; HUMAN; HYPOTHALAMUS; METABOLISM; MOLECULAR GENETICS; OSCILLOMETRY; PHYSIOLOGY; PROTEIN BINDING; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CIRCADIAN RHYTHM; HUMANS; HYPOTHALAMUS; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; OSCILLOMETRY; PEPTIDES; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 43849113416     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/400_2007_054     Document Type: Review

References (33)

1. Brown DR, Quito FL (1988) Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur J Pharmacol 155:159-162
2. Chen T, Zhou M, Walker B, Harriot P, Mori K, Miyazato M, Kangawa K, Shaw C (2006) Structural and functional analogs of the novel mammalian neuropeptide, neuromedin S (NmS), in the dermal venoms of Eurasian bombinid toads. Biochem Biophys Res Commun 345:377-384
3. Civelli O (1998) Functional genomics: The search for novel neurotransmitters and neuropeptides. FEBS Lett 430:55-58
4. Civelli O, Saito Y, Wang Z, Nothacker HP, Reinscheid RK (2006) Orphan GPCRS and their ligands. Pharmacol Ther 110:525-532
5. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M (2000) Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem 275:21068-21074
6. Graham ES, Turnbull Y, Fotheringham P, Nilaweera K, Mercer JG, Morgan PJ, Barrett P (2003) Neuromedin U and neuromedin U receptor-2 expression in the mouse and rat hypothalamus: Effects of nutritional status. J Neurochem 87:1165-1173
7. Hanada R, Nakazato M, Murakami N, Sakihara S, Yoshimatsu H, Toshinai K, Hanada T, Suda T, Kangawa K, Matsukura S (2001) A role for neuromedin U in stress response. Biochem Biophys Res Commun 289:225-228
8. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M (2004) Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10:1067-1073
9. Hanada T, Date Y, Shimbara T, Sakihara S, Murakami N, Hayashi Y, Kanai Y, Suda T, Kangawa K, Nakazato M (2003) Central action of neuromedin U via corticotropin-releasing hormone. Biochem Biophys Res Commun 311:954-958
10. Hedrick JA, Morse K, Shan L, Qiao X, Pang L, Wang S, Laz T, Gustafson EL, Bayne M, Monsma FJ Jr (2000) Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58:870-875
11. Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, Shintani Y, Fukusumi S, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M (2000) Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem 275:29528-29532
12. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, Mckee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LHT, Liu Q (2000) Identification of receptors for neuromedin U and its role in feeding. Nature 406:70-74
13. Ida T, Mori K, Miyazato M, Egi Y, Abe S, Nakahara K, Nishihara M, Kangawa K, Murakami N (2005) Neuromedin S is a novel anorexigenic hormone. Endocrinology 146:4217-4223
14. Kojima M, Haruno R, Nakazato M, Date Y, Murakami N, Hanada R, Matsuo H, Kangawa K (2000) Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem Biophys Res Commun 276:435-438
15. Lowrey PL, Takahashi JS (2000) Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet 34:533-562
16. Minamino N, Kangawa K, Matsuo H (1985) Neuromedin U-8 and U-25: Novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem Biophys Res Commun 130:1078-1085
17. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J 24:325-335
18. Moriyama M, Sato T, Inoue H, Fukuyama S, Teranishi H, Kangawa K, Kano T, Yoshimura A, Kojima M (2005) The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J Exp Med 202:217-224
19. Mrosovsky N (1996) Locomotor activity and non-photic influences on circadian clocks. Biol Rev 71:343-372
20. Nakahara K, Hanada R, Murakami N, Teranishi H, Ohgusu H, Fukushima N, Moriyama M, Ida T, Kangawa K, Kojima M (2004a) The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun 318:156-161
21. Nakahara K, Kojima M, Hanada R, Egi Y, Ida T, Miyazato M, Kangawa K, Murakami N (2004b) Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice. Biochem Biophys Res Commun 323:615-620
22. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, Matsukura S (2000) Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 277:191-194
23. Piggins HD, Cutler DJ (2003) The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. J Endocrinol 177:7-15
24. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS, Dai M, Lerman GS, Vaysse PJ, Branchek TA, Gerald C, Forray C, Adham N (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem 275:32452-32459
25. Reppert SM, Weaver DR (2001) Molecular analysis of mammalian circadian rhythms. Ann Rev Physiol 63:647-676
26. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418:935-941
27. Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Samejima H, Murakami N (2007) Neuromedin S exerts an antidiuretic action in rats. Biochem Biophys Res Commun 361:457-461
28. Shousha S, Nakahara K, Sato M, Mori K, Miyazato M, Kangawa K, Murakami N (2005) Effect of neuromedin S on feeding regulation in the Japanese quail. Neurosci Lett 391:87-90
29. Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD (1998) Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Genomics 52:223-229
30. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J (2005) Obesity and metabolic syndrome in circadian clock mutant mice. Science 308:1043-1045
31. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003) The G protein-coupled receptor repertories of human and mouse. Proc Natl Acad Sci USA 100:4903-4908
32. Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M (2007) Neuromedin S as novel putative regulator of luteinizing hormone secretion. Endocrinology 148:813-823
33. Yu XH, Cao CQ, Mennicken F, Puma C, Dray A, O'Donnell D, Ahmad S, Perkins M (2003) Pro-nociceptive effects of neuromedin U in rat. Neuroscience 120:467-474