Fusion of HSP70 gene of Mycobacterium tuberculosis to hemagglutinin (H5) gene of avian influenza virus in DNA vaccine enhances its potency

Acta Virologica

Volumn 54, Issue 1, 2010, Pages 33-39

  Rasoli, M ^a   Omar, A R ^a   Aini, I ^a   Jalilian, B ^a   Hassan, S H Syed ^b   Mohamed, M ^c  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

^c VETERINARY RESEARCH INSTITUTE   (Malaysia)

Author keywords

Avian influenza virus; DNA vaccine; Hemagglutinin H5; HSP70; Humoral immunity

Indexed keywords

AVIAN INFLUENZA VACCINE; BACTERIAL DNA; BACTERIAL PROTEIN; DNA VACCINE; HEAT SHOCK PROTEIN 70; HEMAGGLUTINATION INHIBITING ANTIBODY; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS DNA; VIRUS HEMAGGLUTININ; VIRUS HEMAGGLUTININ 5 HEAT SHOCK PROTEIN 70 AVIAN INFLUENZA VACCINE; HEMAGGLUTININ, AVIAN INFLUENZA A VIRUS; HSP70 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; HYBRID PROTEIN; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; AVIAN INFLUENZA; AVIAN INFLUENZA VIRUS; CHICKEN; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG DESIGN; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE FUSION; HEMAGGLUTINATION INHIBITION TEST; IMMUNOGENICITY; INFLUENZA VIRUS A H5N1; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMID; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; VACCINE PRODUCTION; VERO CELL; VIRUS IMMUNITY; WESTERN BLOTTING; ANIMAL; ANIMAL DISEASE; BIRD DISEASE; BLOOD; CERCOPITHECUS; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; VACCINATION; VIROLOGY;

AVIAN INFLUENZA VIRUS; GALLUS GALLUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTIBODIES, VIRAL; BACTERIAL PROTEINS; CERCOPITHECUS AETHIOPS; CHICKENS; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA VACCINES; PLASMIDS; POULTRY DISEASES; RECOMBINANT FUSION PROTEINS; VACCINATION; VACCINES, DNA; VERO CELLS;

EID: 77952300829     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2010_01_33     Document Type: Article

References (30)

1. Boyle DB, Selleck P, Heine HG. (2000) Vaccinating chickens against avian influenza with fowlpox recombinants expressing the H7 haemagglutinin. Aust. Vet. J. 78, 44-48.
2. Chen C, Wang T, Hung C, Yang Y, Young RA, Pardoll DM. (2000) Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res. 60, 1035-1042.
3. De Jong MD, Hien TT. (2005) Avian influenza A (H5N1). J. Clin. Virol. 35, 2-13.
4. Hoffmann E, Neumann G, Kawaoka Y, Hobom G, Webster RG. (2000) A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. USA. 97, 6108-6113.
5. Jäättelä M. (1999) Heat shock proteins as cellular lifeguards. Annal. Med. 31, 261-271.
6. Jiang Y, Yu K, Zhang H, Zhang P, Li C, Tian G, Li Y, Wang X, Ge J, Bu Z, Chen H. (2007) Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector. Antiviral Res. 75, 234-241.
7. Johansson BE. (1999) Immunization with influenza A virus hemagglutinin and neuraminidase produced in recombinant baculovirus results in a balanced and broadened immune response superior to conventional vaccine. Vaccine 17, 2073-2080.
8. Kendal AP, Pereira MS, Skehel JJ. (1982) Hemagglutination inhibition. In Kendal AP, Pereira, MS and Skehel, J.J. (Ed.) Concepts and Procedures for Laboratory-Based Influenza Surveillance. Atlanta, GA, Centers for Disease Control and Prevention, pp. B17-B35.
9. Kodihalli S, Haynes JR, Robinson HL, Webster RG. (1997) Crossprotection among lethal H5N2 influenza viruses induced by DNA vaccine to the hemagglutinin. J. Virol. 71, 3391-3396.
10. Kodihalli S, Goto, H, Kobasa DL, Krauss S, Kawaoka Y, Webster RG. (1999) DNA vaccine encoding hemagglutinin providesprotective immunity against H5N1 influenza virus infection in mice. J. Virol. 73, 2094-2098.
11. Lee C, Senne DA, Suarez DL. (2006) Development and application of reference antisera against 15 hemagglutinin subtypes of influenza virus by DNA vaccination of chickens. Clin. Vacc. Immunol. 13, 395-402.
12. Li J, Ye ZX, Li KN, Cui JH, Li J, Cao YX, Liu YF, Yang SJ. (2007) HSP70 gene fused with hantavirus S segment DNA significantly enhances the DNA vaccine potency against hantaviral nucleocapsid protein in vivo. Vaccine 25, 239-252.
13. Liu MA, McClements W, Ulmer JB, Shiver J, Donnelly J. (1997) Immunization of non-human primates with DNA vaccines. Vaccine 15, 909-912.
14. Liu M, Wood JM, Ellis T, Krauss S, Seiler P, Johnson C, Hoffmann E, Humberd J, Hulse D, Zhang Y, Webster RG, Perez DR. (2003) Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics. Virology 314, 580-590.
15. Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Drape RJ, MacKlin MD, McCabe DE, Swain WF, Olsen CW. (1999) Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine 17, 2245-2258.
16. Macklin MD, Mccabe D, Mcgregor MW, Neumann V, Meyer T, Callan R, Hinshaw VS, Swain WF. (1998) Immunization of pigs with a particle-mediated DNA vaccine to influenza A virus protects against challenge with homologous virus. J. Virol. 72, 1491-1496.
17. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJS, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, Issels RD. (2002) Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J. Immunol. 169, 5424-5432.
18. Normile D. (2004) Influenza Girding for disaster. Asia struggles to keep humans and chickens apart. Science 306, 399.
19. Oh YK, Kim JP, Hwang TS, Ko JJ, Kim JM, Yang JS Kim CK. (2001) Nasal absorption and biodistribution of plasmid DNA an alternative route of DNA vaccine delivery. Vaccine 19, 4519-4525.
20. Qazi KR, Wikman M, Vasconcelos N, Berzins K, Ståhl S, Fernández C. (2005) Enhancement of DNA vaccine potency by linkage of Plasmodium falciparum malarial antigen gene fused with a fragment of HSP70 gene. Vaccine 23, 1114-1125.
21. Qiao CL, Yu KZ, Jiang YP, Jia YQ, Tian GB, Liu M, Deng GH, Wang XR, Meng QW, Tang XY. (2003) Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co-expressing H5 haemagglutinin and N1 neuraminidase genes. Avian Pathol. 32, 25-31.
22. Srivastava P. (2002) Roles of heat-shock proteins in innate and adaptive immunity. Nat. Rev. Immunol. 2, 185-194.
23. Suzue K, Young RA. (1996) Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. J. Immunol. 156, 73-879.
24. Swayne DE, Beck JR, Perdue ML, Beard CW. (2001) Efficacy of vaccines in chickens against highly pathogenic Hong Kong H5N1 avian influenza. Avian Dis. 45, 355-365.
25. Udono H, Yamano T, Kawabata Y, Ueda M, Yui K. (2001) Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70. Int. Immunol. 13, 1233-1242.
26. Villarreal-Chavez C. (2007) Experience of the control of avian influenza in the Americas. Dev. Biol. 130, 53-60.
27. Winegar RA, Monforte JA, Suing KG, Rudd CJ, Maegregar JT. (1996) Determination of tissue distribution of an intramuscular plasmid DNA vaccine using PCR and in situ DNA hybridization. Human Gene Therapy 7, 2185-2192.
28. Wood JM. (2001) Developing vaccines against pandemic influenza. Philos. Trans. Roy. Soc B Biol. Sci. 356, 1953-1960.
29. You ZQ, Yu L, Zhang CZ, Li L, Lu MJ, Mao ZJ, Liu Y, Chu WY. (2007) Distribution and Expression of Recombinant Plasmid Encoding Chicken Interleukin-2. Vet. Res. Comm. 31, 273-285.
30. Zarkov S. (2006) Comparison of haemagglutination inhibition (HI), immunodiffusion (ID) and ELISA tests for detecting anti avian influenza antibodies in chicken after inoculations with inactivated antigen. Revue Méd. Vét. 157, 336-340.