Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices

Chemical Papers

Volumn 64, Issue 3, 2010, Pages 346-353

  Musial, Witold ^a,b   Kokol, Vanja ^a   Voncina, Bojana ^a  

^a UNIVERSITY OF MARIBOR   (Slovenia)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Chlorhexidine; Drug release; Methylcellulose; Poly(acrylic acid); Skin surface; Temperature

Indexed keywords

EID: 77952262644     PISSN: 03666352     EISSN: 13369075     Source Type: Journal    
DOI: 10.2478/s11696-010-0013-y     Document Type: Article

References (33)

1. Balanyk, T. E., & Sandham, H. J. (1985). Development of sustained-release antimicrobial dental varnishes effective against Streptococcus mutans in vivo. Journal of Dental Research, 64, 1356-1360. DOI: 10. 1177/00220345850640120501.
2. Bhavan, K. P., & Warren, D. K. (2009). Surgical preparation solutions and preoperative skin disinfection. The Journal of Hand Surgery, 34, 940-941. DOI: 10. 1016/j. hsa. 2009. 03. 008.
3. Blackburn, R. S., Harvey, A., Kettle, L. L., Manian, A. P., Payne, J. D., & Russell, S. J. (2007). Sorption of chlorhexidine on cellulose: Mechanism of binding and molecular recognition. Journal of Physical Chemistry B, 111, 8775-8784. DOI: 10. 1021/jp070856r.
4. Bonacucina, G., Cespi, M., Misici-Falzi, M., & Palmieri, G. F. (2006). Rheological, adhesive and release characterisation of semisolid Carbopol/tetraglycol systems. International Journal of Pharmaceutics, 307, 129-140. DOI: 10. 1016/j. ijpharm. 2005. 09. 034.
5. Ceschel, G. C., Bergamante, V., Calabrese, V., Biserni, S., Ronchi, C., & Fini, A. (2006). Design and evaluation in vitro of controlled release mucoadhesive tablets containing chlorhexidine. Drug Development and Industrial Pharmacy, 32, 53-61. DOI: 10. 1080/03639040500388300.
6. Darmstadt, G. L., Hossain, M. M., Choi, Y., Shirin, M., Mullany, L. C., Islam, M., & Saha, S. K. (2007). Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh. The Pediatric Infectious Disease Journal, 26, 492-495. DOI: 10. 1097/01. inf. 0000261927. 90189. 88.
7. Dentino, A. R., Kassab, M. M., & Renner, E. J. (2005). Prevention of periodontal diseases. Dental Clinics of North America, 49, 573-594. DOI: 10. 1016/j. cden. 2005. 03. 005.
8. Emilson, C. G. (1981). Effect of chlorhexidine gel treatment on Streptococcus mutans population in human saliva and dental plaque. Scandinavian Journal of Dental Research, 89, 239-246. DOI: 10. 1111/j. 1600-0722. 1981. tb01677. x.
9. Farkas, E., Zelkó, R., Németh, Zs., Pálinkás, J., Marton, S., & Rácz, I. (2000). The effect of liquid crystalline structure on chlorhexidine diacetate release. International Journal of Pharmaceutics, 193, 239-245. DOI: 10. 1016/S0378-5173(99)00346-4.
10. Ford, J. L. (1999). Thermal analysis of hydroxypropylmethylcellulose and methylcellulose: powders, gels and matrix tablets. International Journal of Pharmaceutics, 179, 209-228. DOI: 10. 1016/S0378-5173(98)00339-1.
11. Goldstein, J. I., Newbury, D. E., Echlin, P., Joy, D. C., Romig, A. D., Jr., Lyman, C. E., Fiori, C., & Lifshin, E. (1992). Scanning electron microscopy and X-ray microanalysis (2nd ed., pp. 420-428). New York, NY, USA: Plenum Press.
12. Guzel, A., Ozekinci, T., Ozkan, U., Celik, Y., Ceviz, A., & Belen, D. (2009). Evaluation of the skin flora after chlorhexidine and povidone-iodine preparation in neurosurgical practice. Surgical Neurology, 71, 207-210. DOI: 10. 1016/j. surneu. 2007. 10. 026.
13. Irwin, C. R., McCullough, K. C., & Jones, D. S. (2003). Chlorhexidine-containing mucoadhesive polymeric compacts designed for use in the oral cavity: an examination of their physical properties, in vitro/in vivo drug release properties and clinical acceptability. Journal of Materials Science: Materials in Medicine, 14, 825-832. DOI: 10. 1023/A: 1025637106818.
14. Jamilian, A., Ghasemi, M., Gholami, D., & Kaveh, B. (2008). Clinical effects of 2% chlorhexidine gel on patients undergoing orthodontic treatment. Orthodontic Waves, 67, 162-166. DOI: 10. 1016/j. odw. 2008. 07. 001.
15. Jones, D. S., Brown, A. F., Woolfson, A. D., Dennis, A. C., Matchett, L. J., & Bell, S. E. J. (2000). Examination of the physical state of chlorhexidine within viscoelastic, bioadhesive semisolids using Raman spectroscopy. Journal of Pharmaceutical Science, 89, 563-571. DOI: 10. 1002/(SICI)1520-6017(200005)89: 5〈563:: AID-JPS1〉3. 0. CO; 2-Q.
16. Kanlayanaphotporn, R., & Janwantanakul, P. (2005). Comparison of skin surface temperature during the application of various cryotherapy modalities. Archives of Physical Medicine and Rehabilitation, 86, 1411-1415. DOI: 10. 1016/j. apmr. 2004. 11. 034.
17. Kohli-Bardhan, K., Mukhopadhyay, S., & Chatterjee, S. R. (1985). Viscometric studies of graft copolymers of methylcellulose and polyacrylamide. Defence Science Journal, 35, 47-53.
18. Kundu, P. P., & Kundu, M. (2001). Effect of salts and surfactant and their doses on the gelation of extremely dilute solutions of methyl cellulose. Polymer, 42, 2015-2020. DOI: 10. 1016/S0032-3861(00)00506-1.
19. Kuyyakanond, T., & Quesnel, L. B. (1992). The mechanism of action of chlorhexidine. FEMS Microbiology Letters, 100, 211-215. DOI: 10. 1111/j. 1574-6968. 1992. tb14042. x.
20. Lboutounne, H., Chaulet, J.-F., Ploton, C., Falson, F., & Pirot, F. (2002). Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(e{open}-caprolactone) nanocapsule encapsulated and as a digluconate. Journal of Controlled Release, 82, 319-334. DOI: 10. 1016/S0168-3659(02)00142-6.
21. Lombardi Borgia, S., Schlupp, P., Mehnert, W., & Schäfer-Korting, M. (2008). In vitro skin absorption and drug release - A comparison of six commercial prednicarbate preparations for topical use. European Journal of Pharmaceutics and Biopharmaceutics, 68, 380-389. DOI: 10. 1016/j. ejpb. 2007. 05. 003.
22. Mancuso, D. L., & Knight, K. L. (1992). Effects of prior physical activity on skin surface temperature response of the ankle during and after a 30-minute ice pack application. Journal of Athletic Training, 27, 242-249.
23. Nhung, D. T. T., Freydiere, A.-M., Constant, H., Falson, F., & Pirot, F. (2007). Sustained antibacterial effect of a hand rub gel incorporating chlorhexidine-loaded nanocapsules (Nanochlorex®). International Journal of Pharmaceutics, 334, 166-172. DOI: 10. 1016/j. ijpharm. 2006. 10. 017.
24. Park, N. A., & Irvine, T. F., Jr. (1997). Anomalous viscosity-temperature behavior of aqueous Carbopol solutions. Journal of Rheology, 41, 167-173. DOI: 10. 1122/1. 550813.
25. Roach, R. P., Hatton, J. F., & Gillespie, M. J. (2001). Prevention of the ingress of a known virulent bacterium into the root canal system by intracanal medications. Journal of Endodontics, 27, 657-660. DOI: 10. 1097/00004770-200111000-00001.
26. Sarkar, N. (1979). Thermal gelation properties of methyl and hydroxypropyl methylcellulose. Journal of Applied Polymer Science, 24, 1073-1087. DOI: 10. 1002/app. 1979. 070240420.
27. Şnel, S., İkinci, G., Kaş, S., Yousefi-Rad, A., Sargon, M. F., & Hi{dotless}ncal, A. A. (2000). Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. International Journal of Pharmaceutics, 193, 197-203. DOI: 10. 1016/S0378-5173(99)00334-8.
28. Sheppard, F. C., Mason, D. J., Bloomfield, S. F., & Gant, V. A. (1997). Flow cytometric analysis of chlorhexidine action. FEMS Microbiology Letters, 154, 283-288. DOI: 10. 1111/j. 1574-6968. 1997. tb12657. x.
29. Su, F., Nguyen, N. D., Wang, Z., Cai, Y., Rogiers, P., & Vincent, J.-L. (2005). Fever control in septic shock: beneficial or harmful? Shock, 23, 516-520. DOI: 10. 1097/01. shk. 0000161390. 46688. da.
30. Szejtli, J., & Szente, L. (2005). Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 61, 115-125. DOI: 10. 116/j. ejpb. 2005. 05. 006.
31. United States Pharmacopoeial Convention (2007). United States pharmacopoeia-National formulary (USP31 NF26) (pp. 2155-2156). Rockville, MD, USA: United States Pharmacopoeial Convention.
32. Yue, I. C., Poff, J., Cortés, M. E., Sinisterra, R. D., Faris, C. B., Hildgen, P., Langer, R., & Prasad Shastri, V. (2004). A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials, 25, 3743-3750. DOI: 10. 1016/j. biomaterials. 2003. 09. 113.
33. Zatz, J. L., & Segers, J. D. (1998). Techniques for measuring in vitro release from semisolids. Dissolution Technologies, 5, 3-13.