Safety and effect of chlorhexidine skin cleansing on skin flora of neonates in Bangladesh

Pediatric Infectious Disease Journal

Volumn 26, Issue 6, 2007, Pages 492-495

  Darmstadt, Gary L ^a   Hossain, M Monir ^b   Choi, Yoonjoung ^a   Shirin, Mahfuza ^b   Mullany, Luke C ^a   Islam, Maksuda ^b   Saha, Samir K ^b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b DHAKA SHISHU HOSPITAL   (Bangladesh)

Author keywords

Chlorhexidine; Neonatal sepsis; Newborn; Skin; Skin colonization; Skin flora

Indexed keywords

CHLORHEXIDINE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ANTIBACTERIAL ACTIVITY; ARTICLE; AXILLA; BACTERIAL COLONIZATION; BACTERIUM IDENTIFICATION; BANGLADESH; BODY TEMPERATURE MONITORING; CHILD HOSPITALIZATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; HUMAN; HYGIENE; INGUINAL REGION; NEWBORN; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SKIN CARE; SKIN CULTURE; SKIN FLORA; TREATMENT DURATION; UMBILICUS;

ANTI-INFECTIVE AGENTS, LOCAL; BACTERIA; BANGLADESH; BODY TEMPERATURE; CHLORHEXIDINE; COLONY COUNT, MICROBIAL; HOSPITALIZATION; HUMANS; INFANT, NEWBORN; PLACEBOS; SKIN; SKIN CARE;

EID: 34249786876     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000261927.90189.88     Document Type: Article

References (20)

1. Tielsch JM, Darmstadt GL, Mullany LC, et al. Newborn skin wiping with chlorhexidine reduces neonatal mortality among low birthweight infants in Southern Nepal: a community-based, cluster-randomized trial. Pediatrics. 2007;119(2):e330-e340.
2. Taha TE, Biggar RJ, Broadhead RL, et al. Effect of cleaning the birth canal with antiseptic solution on maternal and newborn morbidity and mortality in Malawi. Brit Med J. 1997;315:216-220.
3. Bakr AF, Karkour T. Effect of predelivery vaginal antisepsis on maternal and neonatal morbidity and mortality in Egypt. J Womens Health. 2005;14:496-501.
4. Denton GW. Chlorhexidine. In: Block SS, ed. Disinfection, Sterilization, and Preservation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001:321-326.
5. Mullany L, Darmstadt GL, Tielsch J. Role of antimicrobial applications to the umbilical cord on bacterial colonization and infection. Pediatr Infect Dis J. 2003;22:996-1002.
6. Mullany LC, Darmstadt GL, Khatry SK, LeClerq SC, Tielsch JM. Safety of neonatal skin cleansing in rural Nepal. Indian Pediatr. 2006;43:117-124.
7. Mullany LC, Darmstadt GL, Tielsch JM. Safety and impact of chlorhexidine antisepsis interventions for improving neonatal health in developing countries. Pediatr Infect Dis J. 2006;25:665-675.
8. Aly R, Maibach HI. Effect of antimicrobial soap containing chlorhexidine on the microbial flora of skin. Appl Environ Microbiol. 1973;31:931-935.
9. Lilly HA, Lowbury EJL. Disinfection of the skin with detergent preparations of Irgasan DP 300 and other antiseptics. BMJ. 1974;4:372-374.
10. Lowbury EJL, Lilly HA, Ayliffe GAJ. Preoperative disinfection of surgeons' hands: use of alcoholic solutions and effects of gloves on skin flora. BMJ. 1974;4:369-372.
11. Malathi I, Millar MR, Leemiong JP, Hedges A, Marlow N. Skin disinfection in preterm infants. Arch Dis Child. 1993;69:312-316.
12. Verber IG, Pagan FS. What cord care - if any? Arch Dis Child. 1993;68:594-596.
13. Dubowitz LMS, Dubowitz V, Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970;77:1-10.
14. Darmstadt GL, Badrawi N, Law PA, et al. Topical therapy with sunflower seed oil prevents nosocomial infections and mortality in premature babies in Egypt: a randomized, controlled clinical trial. Pediatr Infect Dis J. 2004;23:719-725.
15. Nopper AJ, Horii KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT. Topical ointment therapy benefits premature infants. J Pediatr. 1996;128:660-669.
16. Cheesebrough M. Medical Laboratory Manual for Tropical Countries. Vol. 2. London: Tropical Health Technology and Butterworth-Heinemann; 1998:182-183.
17. Mullany L, Darmstadt G, Khatry S, et al. Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomized trial. Lancet. 2006;367:910-918.
18. Davies J, Babb JR, Ayliffe AJ. The effect on the skin flora of bathing with antiseptic solutions. J Antimicrob Chemo. 1977;3:473-481.
19. Darmstadt GL, Saha SK, Ahmed ASMNU, et al. Effect of topical emollient treatment of preterm neonates in Bangladesh on invasion of pathogens into the bloodstream. Pediatr Res. 2007;61:1-7.
20. Lawn J, Cousens S, Zupan J. Four million neonatal deaths: where? when? why? Lancet. 2005;365:891-900.