Sedation and analgesia in acute neurologic disease

Current Opinion in Critical Care

Volumn 16, Issue 2, 2010, Pages 81-91

  Mirski, Marek A ^a   Lewin III, John J ^b  

^a Division of Neuroanesthesiology   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; BUTYROPHENONE; CHLORPROMAZINE; CLONIDINE; DEXMEDETOMIDINE; DIAZEPAM; DROPERIDOL; FENTANYL; HALOPERIDOL; LORAZEPAM; MIDAZOLAM; MORPHINE SULFATE; NARCOTIC AGENT; NEUROLEPTIC AGENT; NORPETHIDINE; OLANZAPINE; OPIATE; PETHIDINE; PHENOTHIAZINE; PROPOFOL; PROPYLENE GLYCOL; REMIFENTANIL; RISPERIDONE; THEOPHYLLINE; THIOPENTAL; UNINDEXED DRUG;

ACUTE DISEASE; AKATHISIA; ANALGESIA; ANALGESIC ACTIVITY; ANAPHYLAXIS; ANESTHESIA INDUCTION; ANESTHESIA LEVEL; ANESTHESIA MECHANISM; ANTEROGRADE AMNESIA; ANXIETY; ANXIETY DISORDER; APNEA; BRADYCARDIA; BRAIN HEMORRHAGE; BRAIN PERFUSION; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONFUSION; CONTINUOUS INFUSION; CRITICALLY ILL PATIENT; DELIRIUM; DIZZINESS; DOSE RESPONSE; DRUG CHOICE; DRUG CLEARANCE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG TOLERABILITY; DYSPHORIA; DYSTONIA; ECG ABNORMALITY; EDITORIAL; EPILEPTIC STATE; EXTRAPYRAMIDAL SYMPTOM; FLUSHING; GASTRIC DYSMOTILITY; GASTROINTESTINAL MOTILITY DISORDER; HALLUCINATION; HEADACHE; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HEMODYNAMIC MONITORING; HUMAN; HYPERCAPNIA; HYPERKALEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOTENSION; HYPOXIA; INJECTION SITE PAIN; INTENSIVE CARE UNIT; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; JAUNDICE; LOADING DRUG DOSE; LOW DRUG DOSE; METABOLIC ACIDOSIS; METABOLIC CLEARANCE RATE; MOTOR DYSFUNCTION; MUSCLE HYPOTONIA; MUSCLE RIGIDITY; MUSCLE WEAKNESS; MYOCLONUS; NAUSEA; NAUSEA AND VOMITING; NEUROLEPTIC MALIGNANT SYNDROME; NEUROLOGIC DISEASE; ORTHOSTATIC HYPOTENSION; PAIN ASSESSMENT; PARKINSONISM; PERIORAL TREMOR; POSTOPERATIVE PAIN; PROLACTIN RELEASE; PRURITUS; QT PROLONGATION; REFLEX DISORDER; RESPIRATION DEPRESSION; RESPIRATORY FAILURE; RESTLESSNESS; RHABDOMYOLYSIS; SEDATION; SEIZURE; SEIZURE THRESHOLD; SEPSIS; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; TARDIVE DYSKINESIA; TORSADE DES POINTES; TRAUMATIC BRAIN INJURY; TREATMENT CONTRAINDICATION; TREATMENT DURATION; TREATMENT INDICATION; URTICARIA; VERTIGO; VOMITING; WITHDRAWAL SYNDROME; XEROSTOMIA;

ACUTE DISEASE; ANALGESIA; ANTIPSYCHOTIC AGENTS; ANXIETY; CONSCIOUS SEDATION; CRITICAL CARE; DELIRIUM; HUMANS; INTENSIVE CARE UNITS; MONITORING, INTRAOPERATIVE; NARCOTICS; PAIN MANAGEMENT; PROPOFOL;

EID: 77952261766     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328337495a     Document Type: Editorial

References (54)

1. Phillips DM. JCAHO pain management standards are unveiled. J Am Med Assoc 2000;284:4-5.
2. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-1477.
3. Hogarth DK, Hall J. Management of sedation in mechanically ventilated patients. Curr Opin Crit Care 2004;10:40-46. (Pubitemid 38183923)
4. Mirski MA, Muffelman B, Ulatowski JA, Hanley DF. Sedation for the critically ill neurologic patient. Crit Care Med 1995;23:2038-2053. (Pubitemid 26002772)
5. Ely EW, Siegel MD, Inouye S. Delirium in the intensive care unit: an underrecognized syndrome of organ dysfunction. Semin Resp Crit Care Med 2001;22:115-126. (Pubitemid 32729506)
6. Thomason JWW, Shintani A, Peterson JF, et al. Intensive Care Delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 nonventilated patients. Crit Care Med 2005; 9: R375-R381.
7. Ramsay MA, Savege TM, Simpson BR, et al. Controlled sedation with alphaxalone-alphadolone. Br Med J 1974;2:656-659.
8. Riker RR, Picard JT, Fraser GL. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med 1999;27:1325-1329. (Pubitemid 29379371)
9. Riker RR, Fraser GL, Simmons LE, Wilkins ML. Validating the Sedation-Agitation Scale with the Bispectral Index and Visual Analog Scale in adult ICU patients after cardiac surgery. Int Care Med 2001;27:853-858.
10. Devlin JW, Boleski G, Mlynarek M, et al. Motor Activity Assessment Scale: a valid and reasonable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit. Crit Care Med 1999;27:1271-1275. (Pubitemid 29379363)
11. Sessler CN, Gosnell MS, Grapp MJ, et al. The Richmond Agitation-Sedation Scale. Validity and reliability in adult intensive care unit patients. Am J Resp Crit Care Med 2002;166:1338-1344.
12. DeJonghe B, Cook D, Griffith L, et al. Adaptation to the intensive care environment (ATICE) : development and validation of a new sedation assessment instrument. Crit Care Med 2003;31:2344-2354. (Pubitemid 37100838)
13. Avripas MB, Smythe MA, Carr A, et al. Development of an intensive care unit bedside sedation scale. Ann Pharmacother 2001;35:262-263.
14. Ely EW, Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). J Am Med Assoc 2003;289:2983-2991. (Pubitemid 37430101)
15. Mirski MA, LeDroux SN, Lewin JJ III, et al. Validity and reliability of an intuitive sedation scoring tool: The Nursing Instrument for the Communication of Sedation (NICS) Abstract. Soc Crit Care Med Ann Mtg 2009.
16. de Lemos J, Tweeddale M, Chittock D. Measuring quality of sedation in adult mechanically ventilated critically ill patients: the Vancouver Interaction and Calmness Scale. J Clin Epidemiol 2000;53:908-919.
17. Weinert C, McFarland L. The state of intubated ICU patients. Development of a two-dimensional sedation rating scale for critically ill adults. Chest 2004;126:1883-1890. (Pubitemid 39643994)
18. LeBlanc JM, Dasta JF, Kane-Gill SL. Role of the bispectral index in sedation monitoring in the ICU. Ann Pharmacother 2006;40:490-500.
19. Gutstein HB, Akil H. Opioid analgesics. In: Hardman JG, Limbird LE, editors. Goodman and Gilman's the pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill; 2001. pp. 569-619.
20. Pasternak GW. Multiple opiate receptors: dé jà vu all over again. Neuropharmacology 2004; 47 (Suppl 1) : 312-323.
21. Rao TLK, Mummaneni N, El-Etr AA. Convulsions: an unusual response to intravenous fentanyl administration. Anesth Analg 1982;61:1020-1021. (Pubitemid 13224431)
22. Murkin JM, Moldenhauer CC, Hug CC, et al. Absence of seizures during induction of anesthesia with high-dose fentanyl. Anesth Analg 1984;63:489-494. (Pubitemid 14145694)
23. De Conno F, Caraceni A, Martini C, et al. Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine. Pain 1991;47:337-339.
24. Flacke JW, Flacke WE, Bloor BC, et al. Histamine release by four narcotics: a double-blind study in humans. Anesth Analg 1987;66:723-730.
25. Charney DS, Mihic SJ, Harris RA. Hypnotics and sedatives. In: Hardman JG, Limbird LE, editors. Goodman and Gilman's the pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill; 2001. pp. 399-427.
26. Sanchez-Izquierdo-Riera JA, Caballero-Cubedo RE, Perez-Vela JL, et al. Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient. Anesth Analg 1998;86:1219-1224.
27. Forster A, Juge O, Morel D. Effects of midazolam on cerebral hemodynamics and cerebral vasomotor responsiveness to carbon dioxide. J Cereb Blood Flow Metab 1983;3:246-249. (Pubitemid 13025510)
28. Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). J Am Med Assoc 2001;286:2703-2710. (Pubitemid 33135077)
29. Bergeron N, Dubois MJ, Dumont M, et al. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med 2001;27:859-864. (Pubitemid 32480514)
30. Pandharipande P, Jackson J, Ely EW. Delirium: acute cognitive dysfunction in the critically ill. Curr Opin Crit Care 2005;11:360-368. (Pubitemid 41248311)
31. Claassen J, Hirsch LJ, Emerson RG, et al. Continuous EEG monitoring and midazolam infusion for refractory nonconvulsive status epilepticus. Neurology 2001;57:1036-1042. (Pubitemid 32880200)
32. Neale BW, Mesler EL, Young M, et al. Propylene glycol-induced lactic acidosis in a patient with normal renal function: a proposed mechanism and monitoring recommendations. Ann Pharmacother 2005;39:1732-1736. (Pubitemid 41393135)
33. Barnes BJ, Gerst C, Terrell AR, Mullins ME. Osmol gap as a surrogate marker for serum propylene glycol concentrations in patients receiving lorazepam for sedation. Pharmacotherapy 2006;26:23-33. (Pubitemid 43082924)
34. Dobrydnjov I, Axelsson K, Samarutel J, Holmstrom B. Postoperative pain relief following intrathecal bupivacaine combined with intrathecal or oral clonidine. Acta Anaesthesiol Scand 2002;46:806-814. (Pubitemid 34800072)
35. Iskandar H, Guillaume E, Dixmerias F, et al. The enhancement of sensory blockade by clonidine selectively added to mepivacaine after midhumeral block. Anesth Analg 2001;93:771-775. (Pubitemid 32783309)
36. Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth 2001;87:684-690.
37. Khan ZP, Munday IT, Jones RM, et al. Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: pharmacodynamic and pharmacokinetic interactions. Br J Anaesth 1999;83:372-380. (Pubitemid 29412688)
38. Tulen JH, van de Wetering BJ, Kruijk MP, et al. Cardiovascular, neuroendocrine, and sedative responses to four graded doses of clonidine in a placebocontrolled study. Biol Psychiatry 1992;32:485-500.
39. Mirski MA, Lewin JJ III, LeDroux SN, et al. Cognitive improvement during continuous sedation in critically ill awake and responsive patients: The Acute Neurological ICU Sedation Trial (ANIST) Abstract. Soc Crit Care Med Ann Mtg 2009.
40. Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs. lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. J Am Med Assoc 2007;298:2644-2653.
41. Szumita PM, Baroletti SA, Anger KE, Wechsler ME. Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine. Am J Health Syst Pharm 2007;64:37-44. (Pubitemid 46395706)
42. Elbaradie S, El Mahalawy FH, Solyman AH. Dexmedetomidine vs. propofol for short-term sedation of postoperative mechanically ventilated patients. J Egypt Natl Canc Inst 2004;16:153-158.
43. ter Minassian A, Beydon L, Decq P, Bonnet F. Changes in cerebral hemodynamics after a single dose of clonidine in severely head-injured patients. Anesth Analg 1997;84:127-132. (Pubitemid 27020972)
44. Aryan HE, Box KW, Ibrahim D, et al. Safety and efficacyofdexmedetomidine in neurosurgical patients. Brain Inj 2006;20:791-798.
45. Talke P, Richardson CA, Scheinin M, Fisher DM. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg 1997;85:1136-1142. (Pubitemid 27471539)
46. Baldessarini RJ, Tarazi FI. Drugs and the treatment of psychiatric disorders: psychosis and mania. In: Hardman JG, Limbird LE, editors. Goodman and Gilman's the pharmacological basis of therapeutics, 10th ed. New York: McGraw-Hill; 2001. pp. 485-520.
47. Attard A, Ranjith G, Taylor D. Delirium and its treatment. CNS Drugs 2008;22:631-644. (Pubitemid 351950095)
48. Misfeldt BB, Jorgensen PB, Spotoft H, Ronde F. The effects of droperidol and fentanyl on intracranial pressure and cerebral perfusion pressure in neurosurgical patients. Br J Anaesth 1976;48:963-968.
49. Lischke V, Behne M, Doelken P, et al. Droperidol causes a dose-dependent prolongation of the QT interval. Anesth Analg 1994;79:983-986. (Pubitemid 24324682)
50. Swerdlow BN, Holley FO. Intravenous anesthetic agents. Pharmacokinetic-pharmacodynamic relationships. Clin Pharmacokinet 1981;6:89-105.
51. Vasile B, Rasulo F, Candiani A, Latronico N. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Int Care Med 2003;29:1417-1425. (Pubitemid 37153585)
52. Alkire MT, Haier RJ. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anaesthesia 2001;86:618-626.
53. Tsuchiya H. Structure-specific membrane-fluidizing effect of propofol. Clin Exp Pharmacol Physiol 2001;28:292-299. (Pubitemid 32250716)
54. Perrier ND, Baerga-Varela Y, Murray MJ. Death related to propofol use in an adult patient. Crit Care Med 2000;28:3071-3074.