Molecular mechanisms of the secretion of cytokines and chemokines from human monocytes activated by pneumococcal surface protein A (PspA): Roles of mitogen-activated protein kinases and NF-kappaB

Microbial Pathogenesis

Volumn 48, Issue 6, 2010, Pages 220-229

  Cao, Ju ^a,b   Chen, Tingmei ^b   Gong, Yi ^b   Ying, Bingwu ^a   Li, Dairong ^b   Xu, Wenchun ^b   Zhang, Xuemei ^b   Wang, Lanlan ^a   Yin, Yibing ^b  

^a SICHUAN UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Chemokine; Cytokine; PspA; Streptococcus pneumoniae

Indexed keywords

BACTERIAL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PNEUMOCOCCAL SURFACE PROTEIN A; RANTES; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ARTICLE; BACTERIAL VIRULENCE; CELL ACTIVATION; CYTOKINE RELEASE; INNATE IMMUNITY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

BACTERIAL PROTEINS; CELLS, CULTURED; CHEMOKINES; CYTOKINES; HUMANS; INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; SIGNAL TRANSDUCTION;

STREPTOCOCCUS PNEUMONIAE;

EID: 77952236561     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2010.03.001     Document Type: Article

References (32)

1. Bogaert D., De Groot R., Hermans P.W. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 2004, 4:144-154.
2. Cripps A.W., Leach A.J., Lehmann D. Pneumococcal vaccination in developing countries. Lancet 2006, 368:644.
3. Kadioglu A., Weiser J.N., Paton J.C., Andrew P.W. The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat Rev Microbiol 2008, 2008(6):288-301.
4. Bergmann S., Hammerschmidt S. Versatility of pneumococcal surface proteins. Microbiology 2006, 152:295-303.
5. Briles D.E., Tart R.C., Swiatlo E., Dillard J.P., Smith P., Benton K.A., et al. Pneumococcal diversity: considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA). Clin Microbiol Rev 1998, 11:645-657.
6. Miyaji E.N., Ferreira D.M., Lopes A.P., Brandileone M.C., Dias W.O., Leite L.C. Analysis of serum cross-reactivity and cross-protection elicited by immunization with DNA vaccines against Streptococcus pneumoniae expressing PspA fragments from different clades. Infect Immun 2002, 70:5086-5090.
7. Hollingshead S.K., Becker R., Briles D.E. Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae. Infect Immun 2000, 68:5889-5900.
8. Shaper M., Hollingshead S.K., Benjamin W.H., Briles D.E. PspA protects Streptococcus pneumoniae from killing by apolactoferrin, and antibody to PspA enhances killing of pneumococci by apolactoferrin. Infect Immun 2004, 72:5031-5040.
9. Ren B., Szalai A.J., Hollingshead S.K., Briles D.E. Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface. Infect Immun 2004, 72:114-122.
10. King Q.O., Lei B., Harmsen A.G. Pneumococcal surface protein A contributes to secondary Streptococcus pneumoniae infection after influenza virus infection. J Infect Dis 2009, 200:537-545.
11. Ferreira D.M., Darrieux M., Silva D.A., Leite L.C., Ferreira J.M., Ho P.L., et al. Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice. Clin Vaccine Immunol 2009, 16:636-645.
12. Auffray C., Sieweke M.H., Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009, 27:669-692.
13. Tam M.A., Rydström A., Sundquist M., Wick M.J. Early cellular responses to Salmonella infection: dendritic cells, monocytes, and more. Immunol Rev 2008, 225:140-162.
14. Roche H., Ren B., McDaniel L.S., Håkansson A., Briles D.E. Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae. Infect Immun 2003, 71:4498-4505.
15. Cao J., Chen D., Xu W., Chen T., Xu S., Luo J., et al. Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP. Vaccine 2007, 25:4996-5005.
16. Zhang Z., Clarke T.B., Weiser J.N. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J Clin Invest 2009, 119:1899-1909.
17. Swiatlo E., King J., Nabors G.S., Mathews B., Briles D.E. Pneumococcal surface protein A is expressed in vivo, and antibodies to PspA are effective for therapy in a murine model of pneumococcal sepsis. Infect Immun 2003, 71:7149-7153.
18. Tuomanen E. Molecular and cellular biology of pneumococcal infection. Curr Opin Microbiol 1999, 2:35-39.
19. Ogunniyi A.D., Giammarinaro P., Paton J.C. The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 2002, 148:2045-2053.
20. Dienz O., Rincon M. The effects of IL-6 on CD4 T cell responses. Clin Immunol 2009, 130:27-33.
21. Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007, 8:942-949.
22. Baggiolini M., Dewald B., Moser B. Human chemokines: an update. Annu Rev Immunol 1997, 15:675-705.
23. Lu Y.J., Gross J., Bogaert D., Finn A., Bagrade L., Zhang Q., et al. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog 2008, 4:e1000159.
24. Winter C., Taut K., Srivastava M., Länger F., Mack M., Briles D.E., et al. Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol 2007, 178:5828-5838.
25. Pouysségur J., Volmat V., Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem Pharmacol 2002, 64:755-763.
26. Bernatoniene J., Zhang Q., Dogan S., Mitchell T.J., Paton J.C., Finn A. Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases. J Infect Dis 2008, 198:1823-1833.
27. Lee C.H., Chen R.F., Liu J.W., Yeh W.T., Chang J.C., Liu P.M., et al. Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. J Immunol 2004, 172:7841-7847.
28. Murdoch C., Read R.C., Zhang Q., Finn A. Choline-binding protein A of Streptococcus pneumoniae elicits chemokine production and expression of intercellular adhesion molecule 1 (CD54) by human alveolar epithelial cells. J Infect Dis 2002, 186:1253-1260.
29. Braun J.S., Novak R., Gao G., Murray P.J., Shenep J.L. Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages. Infect Immun 1999, 67:3750-3756.
30. Kang E.H., Gebru E., Kim M.H., Cheng H., Park S.C. EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-kappaB/MAPK. Microb Pathog 2009, 47:196-201.
31. Hashimoto S., Matsumoto K., Gon Y., Maruoka S., Kujime K., Hayashi S., et al. p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. Clin Exp Allergy 2000, 30:48-55.
32. Baldwin A.S. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996, 14:649-683.