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Volumn 8, Issue 5, 2010, Pages 625-634

New challenges for a second-generation low-molecular-weight heparin: Focus on bemiparin

Author keywords

Bemiparin; Deep venous thrombosis; Low molecular weight heparin; Prophylaxis; Pulmonary embolism; Treatment; Venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; BEMIPARIN; BLOOD CLOTTING FACTOR 10A; DALTEPARIN; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; PLACEBO; PROTHROMBIN; REVIPARIN; TINZAPARIN;

EID: 77952235069     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.10.35     Document Type: Review
Times cited : (11)

References (54)
  • 1
    • 46049090201 scopus 로고    scopus 로고
    • Prevention of Venous Thromboembolism. American College of Chest physicians evidence-based clinical practice guidelines (8th edition)
    • Geerts WH, Bergqvist D, Pineo GF et al. Prevention of Venous Thromboembolism. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133(6 Suppl.), 381S-453S (2008).
    • (2008) Chest , vol.133 , Issue.6 SUPPL.
    • Geerts, W.H.1    Bergqvist, D.2    Pineo, G.F.3
  • 2
    • 30944433554 scopus 로고    scopus 로고
    • Incidence of venous thromboembolism in patients hospitalized with cancer
    • DOI 10.1016/j.amjmed.2005.06.058, PII S0002934305005644
    • Stein PD, Beemath A, Meyers FA, Skaf E, Sanchez J, Olson RE. Incidence of venous thromboembolism in patients hospitalized with cancer. Am. J. Med. 119(1), 60-68 (2006). (Pubitemid 43117468)
    • (2006) American Journal of Medicine , vol.119 , Issue.1 , pp. 60-68
    • Stein, P.D.1    Beemath, A.2    Meyers, F.A.3    Skaf, E.4    Sanchez, J.5    Olson, R.E.6
  • 3
    • 34247568441 scopus 로고    scopus 로고
    • Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy
    • Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J. Thromb. Haemost. 5(3), 632-634 (2007).
    • (2007) J. Thromb. Haemost. , vol.5 , Issue.3 , pp. 632-634
    • Khorana, A.A.1    Francis, C.W.2    Culakova, E.3    Kuderer, N.M.4    Lyman, G.H.5
  • 4
  • 5
    • 33846677554 scopus 로고    scopus 로고
    • Management of venous thromboembolism: A systematic review for a practice guideline
    • Segal JB, Streiff MB, Hofmann LV, Thornton K, Bass EB. Management of venous thromboembolism: a systematic review for a practice guideline. Ann. Intern. Med. 146(3), 211-222 (2007).
    • (2007) Ann. Intern. Med. , vol.146 , Issue.3 , pp. 211-222
    • Segal, J.B.1    Streiff, M.B.2    Hofmann, L.V.3    Thornton, K.4    Bass, E.B.5
  • 6
    • 33645515458 scopus 로고    scopus 로고
    • Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction
    • Antman EM, Morrow DA, McCabe CH et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N. Engl. J. Med. 354(14), 1477-1488 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , Issue.14 , pp. 1477-1488
    • Antman, E.M.1    Morrow, D.A.2    McCabe, C.H.3
  • 7
    • 34249336017 scopus 로고    scopus 로고
    • Enoxaparin in acute coronary syndromes
    • Lee S, Gibson CM. Enoxaparin in acute coronary syndromes. Expert Rev. Cardiovasc. Ther. 5(3), 387-399 (2007).
    • (2007) Expert Rev. Cardiovasc. Ther. , vol.5 , Issue.3 , pp. 387-399
    • Lee, S.1    Gibson, C.M.2
  • 8
    • 0037775584 scopus 로고    scopus 로고
    • Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer
    • Lee AY, Levine MN, Baker RI et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N. Engl. J. Med. 349(2), 146-153 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , Issue.2 , pp. 146-153
    • Lee, A.Y.1    Levine, M.N.2    Baker, R.I.3
  • 9
    • 69549083075 scopus 로고    scopus 로고
    • International recommendations for the prevention and treatment of venous thromboembolism associated with cancer
    • Khosravi-Shahi P, Pérez-Manga G. International recommendations for the prevention and treatment of venous thromboembolism associated with cancer. Clin. Drug. Investig. 29(10), 625-633 (2009).
    • (2009) Clin. Drug. Investig. , vol.29 , Issue.10 , pp. 625-633
    • Khosravi-Shahi, P.1    Pérez-Manga, G.2
  • 10
    • 85047693100 scopus 로고
    • From the food and drug administration
    • Nightingale SL. From the Food and Drug Administration. JAMA 270(14), 1672 (1993).
    • (1993) JAMA , vol.270 , Issue.14 , pp. 1672
    • Nightingale, S.L.1
  • 11
    • 0035125405 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety
    • Hirsh J, Warkentin TE, Shaughnessy SG et al. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy, and safety. Chest 119(1 Suppl.), 64S-94S (2001).
    • (2001) Chest , vol.119 , Issue.1 SUPPL.
    • Hirsh, J.1    Warkentin, T.E.2    Shaughnessy, S.G.3
  • 12
    • 0032882186 scopus 로고    scopus 로고
    • 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction
    • A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction)
    • Ryan TJ, Antman EM, Brooks NH et al. 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J. Am. Coll. Cardiol. 34(3), 890-911 (1999).
    • (1999) J. Am. Coll. Cardiol. , vol.34 , Issue.3 , pp. 890-911
    • Ryan, T.J.1    Antman, E.M.2    Brooks, N.H.3
  • 13
    • 0141740242 scopus 로고    scopus 로고
    • Review of bemiparin sodium - A new second-generation low molecular weight heparin and its applications in venous thromboembolism
    • Planès A. Review of bemiparin sodium - a new second-generation low molecular weight heparin and its applications in venous thromboembolism. Expert Opin. Pharmacother. 4(9), 1551-1561 (2003).
    • (2003) Expert Opin. Pharmacother. , vol.4 , Issue.9 , pp. 1551-1561
    • Planès, A.1
  • 14
    • 48249113988 scopus 로고    scopus 로고
    • Bemiparin: Second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism
    • Martínez-González J, Vila L, Rodríguez C. Bemiparin: second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism. Expert Rev. Cardiovasc. Ther. 6(6), 793-802 (2008).
    • (2008) Expert Rev. Cardiovasc. Ther. , vol.6 , Issue.6 , pp. 793-802
    • Martínez-González, J.1    Vila, L.2    Rodríguez, C.3
  • 15
    • 34249064312 scopus 로고    scopus 로고
    • Low-molecular-weight heparins: Before or after surgery? New concepts and evidence: Congress report from the Sigma Tau/ROVI Satellite Symposium (Rome Italy 13 November 2006)
    • Rocha E, Imberti D, Paschina E. Low-molecular-weight heparins: before or after surgery? New concepts and evidence: congress report from the Sigma Tau/ROVI Satellite Symposium (Rome, Italy, 13 November 2006). Clin. Drug Investig. 27(5), 357-366 (2007).
    • (2007) Clin. Drug Investig. , vol.27 , Issue.5 , pp. 357-366
    • Rocha, E.1    Imberti, D.2    Paschina, E.3
  • 16
    • 0142248246 scopus 로고    scopus 로고
    • Bemiparin: A review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis
    • Chapman TM, Goa KL. Bemiparin: a review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis. Drugs 63(21), 2357-2377 (2003).
    • (2003) Drugs , vol.63 , Issue.21 , pp. 2357-2377
    • Chapman, T.M.1    Goa, K.L.2
  • 17
    • 12444301735 scopus 로고    scopus 로고
    • Comparative study of the pharmacokinetic profiles of two LMWH-bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa)-administered subcutaneously to healthy male volunteers
    • Depasse F, González de Suso MJ, Lagoutte I, Fontcuberta J, Borrell M, Samama MM. Comparative study of the pharmacokinetic profiles of two LMWH-bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa)-administered subcutaneously to healthy male volunteers. Thromb. Res. 109(2-3), 109-117 (2003).
    • (2003) Thromb. Res. , vol.109 , Issue.2-3 , pp. 109-117
    • Depasse, F.1    González De Suso, M.J.2    Lagoutte, I.3    Fontcuberta, J.4    Borrell, M.5    Samama, M.M.6
  • 18
    • 34247869897 scopus 로고    scopus 로고
    • Effect of the anti-factor Xa and anti-factor IIa activities of low-molecular-weight heparins upon the phases of thrombin generation
    • Gerotziafas GT, Petropoulou AD, Verdy E, Samama MM, Elalamy I. Effect of the anti-factor Xa and anti-factor IIa activities of low-molecular-weight heparins upon the phases of thrombin generation. J. Thromb. Haemost. 5(5), 955-962 (2007).
    • (2007) J. Thromb. Haemost. , vol.5 , Issue.5 , pp. 955-962
    • Gerotziafas, G.T.1    Petropoulou, A.D.2    Verdy, E.3    Samama, M.M.4    Elalamy, I.5
  • 19
    • 71849116146 scopus 로고    scopus 로고
    • Comparative pharmacodynamic time-course of bemiparin and enoxaparin in healthy volunteers
    • Antonijoan RM, Rico S, Martínez- González J et al. Comparative pharmacodynamic time-course of bemiparin and enoxaparin in healthy volunteers. Int. J. Clin. Pharmacol. Ther. 47, 726-732 (2009).
    • (2009) Int. J. Clin. Pharmacol. Ther. , vol.47 , pp. 726-732
    • Antonijoan, R.M.1    Rico, S.2    Martínez-González, J.3
  • 20
    • 22144465855 scopus 로고    scopus 로고
    • Comparison of two low-molecular weight heparins (LMWH), tinzaparin and bemiparin, during hemodialysis
    • Christidou FN, Frangia TK, Bamichas GI et al. Comparison of two low-molecular weight heparins (LMWH), tinzaparin and bemiparin, during hemodialysis. Int. J. Clin. Pharmacol. Ther. 43(7), 335-338 (2005).
    • (2005) Int. J. Clin. Pharmacol. Ther. , vol.43 , Issue.7 , pp. 335-338
    • Christidou, F.N.1    Frangia, T.K.2    Bamichas, G.I.3
  • 21
    • 4243892912 scopus 로고    scopus 로고
    • Pharmacokinetic profile of two LMWH: Bemiparin 3500 IU and enoxaparin 4000 IU after sc administration in healthy volunteers (18th Congress of the International Society of Thrombosis and Haemostasis. Paris France (2001)
    • Borrell M, Antonijoan RM, Ortiz R et al. Pharmacokinetic profile of two LMWH: bemiparin 3500 IU and enoxaparin 4000 IU after sc administration in healthy volunteers (18th Congress of the International Society of Thrombosis and Haemostasis. Paris, France, 2001). Thromb. Haemost. 86(Suppl.), CD3578 (2001).
    • (2001) Thromb. Haemost. , vol.86 , Issue.SUPPL.
    • Borrell, M.1    Antonijoan, R.M.2    Ortiz, R.3
  • 22
    • 0028947545 scopus 로고
    • Kinetic behaviour of the TFPI and anti-FXa effects, after the injection of a LMWH(RO-11) in healthy subjects
    • Falkon L, Garí M, Sáenz-Campos D, Antonijoan R, Barbanoj M, Fontcuberta J. Kinetic behaviour of the TFPI and anti-FXa effects, after the injection of a LMWH(RO-11) in healthy subjects. Thromb. Haemost. 73(4), 728-729 (1995).
    • (1995) Thromb. Haemost. , vol.73 , Issue.4 , pp. 728-729
    • Falkon, L.1    Garí, M.2    Sáenz-Campos, D.3    Antonijoan, R.4    Barbanoj, M.5    Fontcuberta, J.6
  • 23
    • 0031977005 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, bemiparin, at therapeutic sc doses
    • Falkon L, Garí M, Barbanoj M, Amiral J, Fontcuberta J. Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, bemiparin, at therapeutic sc doses. Blood Coagul. Fibrinolysis 9(2), 137-141 (1998).
    • (1998) Blood Coagul. Fibrinolysis , vol.9 , Issue.2 , pp. 137-141
    • Falkon, L.1    Garí, M.2    Barbanoj, M.3    Amiral, J.4    Fontcuberta, J.5
  • 24
    • 0034106458 scopus 로고    scopus 로고
    • A comparative, double-blind, randomized trial of a new second generation LMWH (bemiparin) and UFH in the prevention of post-operative venous thromboembolism
    • The Bemiparin Assessment group
    • Kakkar VV, Howes J, Sharma V, Kadziola Z. A comparative, double-blind, randomized trial of a new second generation LMWH (bemiparin) and UFH in the prevention of post-operative venous thromboembolism. The Bemiparin Assessment group. Thromb. Haemost. 83, 523-529 (2000).
    • (2000) Thromb. Haemost. , vol.83 , pp. 523-529
    • Kakkar, V.V.1    Howes, J.2    Sharma, V.3    Kadziola, Z.4
  • 25
    • 0141823421 scopus 로고    scopus 로고
    • Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: A randomized, double-blind clinical trial
    • Navarro-Quilis A, Castellet E, Rocha E et al. Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: a randomized, double-blind clinical trial. J. Thromb. Haemost. 1(3), 425-432 (2003).
    • (2003) J. Thromb. Haemost. , vol.1 , Issue.3 , pp. 425-432
    • Navarro-Quilis, A.1    Castellet, E.2    Rocha, E.3
  • 26
    • 4644307098 scopus 로고    scopus 로고
    • Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous thromboembolism in total knee replacement surgery
    • Honorato J, Gómez-Outes A, Navarro- Quilis A, Martínez- González J, Rocha E, Planès A. Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous thromboembolism in total knee replacement surgery. Pharmacoeconomics 22(13), 885-894 (2004).
    • (2004) Pharmacoeconomics , vol.22 , Issue.13 , pp. 885-894
    • Honorato, J.1    Gómez-Outes, A.2    Navarro-Quilis, A.3    Martínez- González, J.4    Rocha, E.5    Planès, A.6
  • 27
    • 34548166531 scopus 로고    scopus 로고
    • A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery
    • Abad JI, Gómez-Outes A, Martínez- González J et al. A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery. Arch. Orthop. Trauma Surg. 127(8), 665-670 (2007).
    • (2007) Arch. Orthop. Trauma Surg. , vol.127 , Issue.8 , pp. 665-670
    • Abad, J.I.1    Gómez-Outes, A.2    Martínez-González, J.3
  • 28
    • 37549060400 scopus 로고    scopus 로고
    • Evaluation of the effectiveness and safety of bemiparin in a large population of orthopedic patients in a normal clinical practice
    • Otero-Fernández R, Gómez-Outes A, Martínez- González J et al. Evaluation of the effectiveness and safety of bemiparin in a large population of orthopedic patients in a normal clinical practice. Clin. Appl. Thromb. Hemost. 14(1), 75-83 (2008).
    • (2008) Clin. Appl. Thromb. Hemost. , vol.14 , Issue.1 , pp. 75-83
    • Otero-Fernández, R.1    Gómez-Outes, A.2    Martínez- González, J.3
  • 29
    • 68849121895 scopus 로고    scopus 로고
    • A prospective cohort study on the effectiveness of 3500 IU versus 5000 IU bemiparin in the prophylaxis of postoperative thrombotic events in obese patients undergoing orthopedic surgery
    • Vavken P, Lunzer A, Grohs JG. A prospective cohort study on the effectiveness of 3500 IU versus 5000 IU bemiparin in the prophylaxis of postoperative thrombotic events in obese patients undergoing orthopedic surgery. Wien. Klin. Wochenschr. 121(13-14), 454-458 (2009).
    • (2009) Wien. Klin. Wochenschr. , vol.121 , Issue.13-14 , pp. 454-458
    • Vavken, P.1    Lunzer, A.2    Grohs, J.G.3
  • 30
    • 34247367703 scopus 로고    scopus 로고
    • Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: An audit of practice
    • Balibrea JL, Altimiras J, Larruzea I et al. Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice. Int. J. Surg. 5(2), 114-119 (2007).
    • (2007) Int. J. Surg. , vol.5 , Issue.2 , pp. 114-119
    • Balibrea, J.L.1    Altimiras, J.2    Larruzea, I.3
  • 31
    • 33847027686 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy
    • Constans M, Santamaria A, Mateo J, Pujol N, Souto JC, Fontcuberta J. Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int. J. Clin. Pract. 61(2), 212-217 (2007).
    • (2007) Int. J. Clin. Pract. , vol.61 , Issue.2 , pp. 212-217
    • Constans, M.1    Santamaria, A.2    Mateo, J.3    Pujol, N.4    Souto, J.C.5    Fontcuberta, J.6
  • 32
    • 22544463642 scopus 로고    scopus 로고
    • Utilisation and safety of bemiparin, a low-molecular-weight heparin, in medical patients: A prospective, uncontrolled cohort study
    • Miras-Parra F, Navascués-Martínez E, Gómez-Outes A et al. Utilisation and safety of bemiparin, a low-molecular-weight heparin, in medical patients: a prospective, uncontrolled cohort study. Clin. Drug Investig. 25(7), 463-472 (2005).
    • (2005) Clin. Drug Investig. , vol.25 , Issue.7 , pp. 463-472
    • Miras-Parra, F.1    Navascués-Martínez, E.2    Gómez-Outes, A.3
  • 33
    • 33947700479 scopus 로고    scopus 로고
    • Safety and effectiveness of bemiparin in the prevention of venous thromboembolic disease in nursing home patients
    • Prieto Seva AJ. Safety and effectiveness of bemiparin in the prevention of venous thromboembolic disease in nursing home patients. Rev. Esp. Geriatr. Gerontol. 42, 20-26 (2007).
    • (2007) Rev. Esp. Geriatr. Gerontol. , vol.42 , pp. 20-26
    • Prieto Seva, A.J.1
  • 35
    • 3042639769 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: Assessment of a standardized periprocedural anticoagulation regimen
    • Douketis JD, Johnson JA, Turpie AG. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arch. Intern. Med. 164(12), 1319-1326 (2004).
    • (2004) Arch. Intern. Med. , vol.164 , Issue.12 , pp. 1319-1326
    • Douketis, J.D.1    Johnson, J.A.2    Turpie, A.G.3
  • 36
    • 24744436630 scopus 로고    scopus 로고
    • Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation
    • Spyropoulos AC, Turpie AG. Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation. Curr. Opin. Pulm. Med. 11(5), 373-379 (2005).
    • (2005) Curr. Opin. Pulm. Med. , vol.11 , Issue.5 , pp. 373-379
    • Spyropoulos, A.C.1    Turpie, A.G.2
  • 37
    • 0037393819 scopus 로고    scopus 로고
    • Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis
    • Kakkar VV, Gebska M, Kadziola Z et al. Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis. Thromb. Haemost. 89(4), 674-680 (2003).
    • (2003) Thromb. Haemost. , vol.89 , Issue.4 , pp. 674-680
    • Kakkar, V.V.1    Gebska, M.2    Kadziola, Z.3
  • 38
    • 32044448965 scopus 로고    scopus 로고
    • Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis
    • Gómez-Outes A, Rocha E, Martínez- González J, Kakkar VV. Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis. Pharmacoeconomics 24(1), 81-92 (2006).
    • (2006) Pharmacoeconomics , vol.24 , Issue.1 , pp. 81-92
    • Gómez-Outes, A.1    Rocha, E.2    Martínez-González, J.3    Kakkar, V.V.4
  • 39
    • 33646229797 scopus 로고    scopus 로고
    • Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: The ESFERA Study
    • Santamaría A, Juárez S, Reche A et al. Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: the ESFERA Study. Int. J. Clin. Pract. 60(5), 518-525 (2006).
    • (2006) Int. J. Clin. Pract. , vol.60 , Issue.5 , pp. 518-525
    • Santamaría, A.1    Juárez, S.2    Reche, A.3
  • 40
    • 33750049003 scopus 로고    scopus 로고
    • Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: The FLEBUS study
    • FLEBUS Investigators
    • Lecumberri R, Rosario E, Pacho J, Rocha E; FLEBUS Investigators. Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: the FLEBUS study. J. Thromb. Haemost. 4(11), 2504-2508 (2006).
    • (2006) J. Thromb. Haemost. , vol.4 , Issue.11 , pp. 2504-2508
    • Lecumberri, R.1    Rosario, E.2    Pacho, J.3    Rocha, E.4
  • 42
    • 50649098601 scopus 로고    scopus 로고
    • Treatment of chronic diabetic foot ulcers with bemiparin: A randomized, triple-blind, placebo-controlled, clinical trial
    • Rullan M, Cerdà L, Frontera G, Masmiquel L, Llobera J. Treatment of chronic diabetic foot ulcers with bemiparin: a randomized, triple-blind, placebo-controlled, clinical trial. Diabet. Med. 25(9), 1090-1095 (2008).
    • (2008) Diabet. Med. , vol.25 , Issue.9 , pp. 1090-1095
    • Rullan, M.1    Cerdà, L.2    Frontera, G.3    Masmiquel, L.4    Llobera, J.5
  • 43
    • 33745218070 scopus 로고    scopus 로고
    • Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer
    • Motlekar NA, Srivenugopal KS, Wachtel MS, Youan BB. Evaluation of the oral bioavailability of low molecular weight heparin formulated with glycyrrhetinic acid as permeation enhancer. Drug. Dev. Res. 67(2), 166-174 (2006).
    • (2006) Drug. Dev. Res. , vol.67 , Issue.2 , pp. 166-174
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 44
    • 33646459320 scopus 로고    scopus 로고
    • Modulation of gastrointestinal permeability of low-molecular-weight heparin by l-arginine: In vivo and in vitro evaluation
    • Motlekar NA, Srivenugopal KS, Wachtel MS, Youan BB. Modulation of gastrointestinal permeability of low-molecular-weight heparin by l-arginine: in vivo and in vitro evaluation. J. Pharm. Pharmacol. 58(5), 591-598 (2006).
    • (2006) J. Pharm. Pharmacol. , vol.58 , Issue.5 , pp. 591-598
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 46
    • 35348863173 scopus 로고    scopus 로고
    • Oral low molecular weight heparin delivery by microparticles from complex coacervation
    • Lamprecht A, Ubrich N, Maincent P. Oral low molecular weight heparin delivery by microparticles from complex coacervation. Eur. J. Pharm. Biopharm. 67(3), 632-638 (2007).
    • (2007) Eur. J. Pharm. Biopharm. , vol.67 , Issue.3 , pp. 632-638
    • Lamprecht, A.1    Ubrich, N.2    Maincent, P.3
  • 47
    • 70849124071 scopus 로고    scopus 로고
    • Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system
    • Lanke SS, Gayakwad SG, Strom JG, D'Souza MJ. Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system. J. Microencapsul. S26(6), 493-500 (2009).
    • (2009) J. Microencapsul. , vol.S26 , Issue.6 , pp. 493-500
    • Lanke, S.S.1    Gayakwad, S.G.2    Strom, J.G.3    D'Souza, M.J.4
  • 48
    • 71049133992 scopus 로고    scopus 로고
    • Pellets for oral administration of low-molecular-weight heparin
    • Scala-Bertola J, Gajdziok J, Rabisková M et al. Pellets for oral administration of low-molecular-weight heparin. Drug Dev. Ind. Pharm. 35(12), 1503-1510 (2009).
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , Issue.12 , pp. 1503-1510
    • Scala-Bertola, J.1    Gajdziok, J.2    Rabisková, M.3
  • 50
    • 28844462321 scopus 로고    scopus 로고
    • Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients
    • Siragusa S, Arcara C, Malato A et al. Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients. Ann. Oncol. 16(Suppl. 4), iv136- iv139 (2005).
    • (2005) Ann. Oncol. , vol.16 , Issue.SUPPL. 4
    • Siragusa, S.1    Arcara, C.2    Malato, A.3
  • 51
    • 70349398317 scopus 로고    scopus 로고
    • Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: A randomised, placebo-controlled, double-blind study
    • PROTECHT Investigators
    • Agnelli G, Gussoni G, Bianchini C et al.; PROTECHT Investigators. Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study. Lancet Oncol. 10(10), 943-949 (2009).
    • (2009) Lancet Oncol. , vol.10 , Issue.10 , pp. 943-949
    • Agnelli, G.1    Gussoni, G.2    Bianchini, C.3
  • 52
    • 69949138571 scopus 로고    scopus 로고
    • Role of low molecular weight heparins in prophylaxis of thromboembolic events on oncological patients with indwelling central venous catheter
    • Calderero Aragón V, de Gregorio Ariza MA, Pazo Cid R et al. Role of low molecular weight heparins in prophylaxis of thromboembolic events on oncological patients with indwelling central venous catheter. Med. Clin. (Barc). 133(10), 365-370 (2009).
    • (2009) Med. Clin. (Barc). , vol.133 , Issue.10 , pp. 365-370
    • Calderero Aragón, V.1    De Gregorio Ariza, M.A.2    Pazo Cid, R.3
  • 53
    • 27744549414 scopus 로고    scopus 로고
    • Venous thromboprophylaxis in UK medical inpatients
    • Rashid ST, Thursz MR, Razvi NA et al. Venous thromboprophylaxis in UK medical inpatients. J. R. Soc. Med. 98(11), 507-512 (2005).
    • (2005) J. R. Soc. Med. , vol.98 , Issue.11 , pp. 507-512
    • Rashid, S.T.1    Thursz, M.R.2    Razvi, N.A.3


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