메뉴 건너뛰기




Volumn 6, Issue 6, 2008, Pages 793-802

Bemiparin: Second-generation, low-molecular-weight heparin for treatment and prophylaxis of venous thromboembolism

Author keywords

Bemiparin; Deep venous thrombosis; Low molecular weight heparin; Prophylaxis; Pulmonary embolism; Treatment; Venous thromboembolism

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTIVITAMIN K; BADYKET; BEMIPARIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; DALTEPARIN; ENOXAPARIN; FONDAPARINUX; HEPADREN; HEPARIN; IVOR; IVORAT; IVORMAX; NADROPARIN; PLACEBO; REVIPARIN; TINZAPARIN; UNCLASSIFIED DRUG; ZIBOR; FACTOR IIA; FIBRINOLYTIC AGENT; LOW MOLECULAR WEIGHT HEPARIN; PROTHROMBIN;

EID: 48249113988     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.6.6.793     Document Type: Article
Times cited : (30)

References (39)
  • 1
    • 0037264105 scopus 로고    scopus 로고
    • Incidence of diagnosed deep vein thrombosis in the general population: Systematic review
    • Fowkes FJ, Price JF, Fowkes FG. Incidence of diagnosed deep vein thrombosis in the general population: systematic review. Eur. J. Vasc. Endovasc. Surg. 25(1), 1-5 (2003).
    • (2003) Eur. J. Vasc. Endovasc. Surg , vol.25 , Issue.1 , pp. 1-5
    • Fowkes, F.J.1    Price, J.F.2    Fowkes, F.G.3
  • 2
    • 0027954653 scopus 로고
    • Autopsy evidence of pulmonary thromboembolism
    • McKelvie PA. Autopsy evidence of pulmonary thromboembolism. Med. J. Aust. 160(3), 127-128 (1994).
    • (1994) Med. J. Aust , vol.160 , Issue.3 , pp. 127-128
    • McKelvie, P.A.1
  • 3
    • 4644288189 scopus 로고    scopus 로고
    • Geerts WH, Pineo GF, Heit JA et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126(3 Suppl.), S338-S400 (2004).
    • Geerts WH, Pineo GF, Heit JA et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126(3 Suppl.), S338-S400 (2004).
  • 4
    • 33846677554 scopus 로고    scopus 로고
    • Management of venous thromboembolism: A systematic review for a practice guideline
    • Segal JB, Streif MB, Hofmann LV, Thornton K, Bass EB. Management of venous thromboembolism: a systematic review for a practice guideline. Ann. Intern. med. 146(3), 211-222 (2007).
    • (2007) Ann. Intern. med , vol.146 , Issue.3 , pp. 211-222
    • Segal, J.B.1    Streif, M.B.2    Hofmann, L.V.3    Thornton, K.4    Bass, E.B.5
  • 5
    • 33645515458 scopus 로고    scopus 로고
    • Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction
    • Antman EM, Morrow DA, McCabe CH et al. Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction. N. Engl. J. Med. 354(14), 1477-1488 (2006).
    • (2006) N. Engl. J. Med , vol.354 , Issue.14 , pp. 1477-1488
    • Antman, E.M.1    Morrow, D.A.2    McCabe, C.H.3
  • 6
    • 34249336017 scopus 로고    scopus 로고
    • Enoxaparin in acute coronary syndromes
    • Lee S, Gibson CM. Enoxaparin in acute coronary syndromes. Expert Rev. Cardiovasc. Ther. 5(3), 387-399 (2007).
    • (2007) Expert Rev. Cardiovasc. Ther , vol.5 , Issue.3 , pp. 387-399
    • Lee, S.1    Gibson, C.M.2
  • 7
    • 2442448579 scopus 로고    scopus 로고
    • Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: Meta-analysis of the randomized comparisons with oral anticoagulants
    • Iorio A. Guercini F, Pini M. Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anticoagulants. J. Thromb. Haemost. 1(9), 1906-1913 (2003).
    • (2003) J. Thromb. Haemost , vol.1 , Issue.9 , pp. 1906-1913
    • Iorio, A.1    Guercini, F.2    Pini, M.3
  • 8
    • 0037775584 scopus 로고    scopus 로고
    • Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer
    • Lee AY, Levine MN, Baker RI et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N. Engl. J. Med. 349(2), 146-153 (2003).
    • (2003) N. Engl. J. Med , vol.349 , Issue.2 , pp. 146-153
    • Lee, A.Y.1    Levine, M.N.2    Baker, R.I.3
  • 9
    • 33644645358 scopus 로고    scopus 로고
    • Guidelines on the use and monitoring of heparin
    • Baglin T, Barrowcliffe TW, Cohen A et al. Guidelines on the use and monitoring of heparin. Br. J. Haematol. 133(1), 19-34 (2006).
    • (2006) Br. J. Haematol , vol.133 , Issue.1 , pp. 19-34
    • Baglin, T.1    Barrowcliffe, T.W.2    Cohen, A.3
  • 10
    • 0141740242 scopus 로고    scopus 로고
    • Review of bemiparin sodium - a new second-generation low molecular weight heparin and its applications in venous thromboembolism
    • Planès A. Review of bemiparin sodium - a new second-generation low molecular weight heparin and its applications in venous thromboembolism. Expert Opin. Pharmacother. 4(9), 1551-1561 (2003).
    • (2003) Expert Opin. Pharmacother , vol.4 , Issue.9 , pp. 1551-1561
    • Planès, A.1
  • 11
    • 0006621485 scopus 로고    scopus 로고
    • Chemical structure-activity ratio of the low molecular weight heparins (HBPM). Towards a second generation of low molecular weight heparins?
    • García Frade LJ, Peñarrubia Ponce MJ. Chemical structure-activity ratio of the low molecular weight heparins (HBPM). Towards a second generation of low molecular weight heparins? Rev. Iberoamer. Tromb. Hemostasia 13, 7-13 (2000).
    • (2000) Rev. Iberoamer. Tromb. Hemostasia , vol.13 , pp. 7-13
    • García Frade, L.J.1    Peñarrubia Ponce, M.J.2
  • 12
    • 34249064312 scopus 로고    scopus 로고
    • Rocha E, Imberd D, Paschina E. Low-molecular-weight hepatitis: before or after surgery? New concepts and evidence: Congress report from the Sigma Tau/ROVI Satellite Symposium (Rome, Italy, 13 November 2006). Clin. Drug Investig. 27(5), 357-366 (2007).
    • Rocha E, Imberd D, Paschina E. Low-molecular-weight hepatitis: before or after surgery? New concepts and evidence: Congress report from the Sigma Tau/ROVI Satellite Symposium (Rome, Italy, 13 November 2006). Clin. Drug Investig. 27(5), 357-366 (2007).
  • 13
    • 0142248246 scopus 로고    scopus 로고
    • Bemiparin: A review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis
    • Chapman TM, Goa KL. Bemiparin: a review of its use in the prevention of venous thromboembolism and treatment of deep vein thrombosis. Drugs 63(21), 2357-2377 (2003).
    • (2003) Drugs , vol.63 , Issue.21 , pp. 2357-2377
    • Chapman, T.M.1    Goa, K.L.2
  • 14
    • 12444301735 scopus 로고    scopus 로고
    • Comparative study of the pharmacokinetic profiles of two LMWH-bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa)-administered subcutaneously to healthy male volunteers
    • Depasse F, González de Suso MJ, Lagoutte I, Fontcuberta J, Borrell M, Samama MM. Comparative study of the pharmacokinetic profiles of two LMWH-bemiparin (3500 IU, anti-Xa) and tinzaparin (4500 IU, anti-Xa)-administered subcutaneously to healthy male volunteers. Thromb. Res. 109(2-3), 109-117 (2003).
    • (2003) Thromb. Res , vol.109 , Issue.2-3 , pp. 109-117
    • Depasse, F.1    González de Suso, M.J.2    Lagoutte, I.3    Fontcuberta, J.4    Borrell, M.5    Samama, M.M.6
  • 15
    • 34247869897 scopus 로고    scopus 로고
    • Effect of the anti-factor Xa and anti-factor IIa activities of low-molecular-weight heparins upon the phases of thrombin generation
    • Gerotziafas GT, Petropoulou AD, Verdy E, Samama MM, Elalamy I. Effect of the anti-factor Xa and anti-factor IIa activities of low-molecular-weight heparins upon the phases of thrombin generation. J. Thromb. Haemost. 5(5), 955-962 (2007).
    • (2007) J. Thromb. Haemost , vol.5 , Issue.5 , pp. 955-962
    • Gerotziafas, G.T.1    Petropoulou, A.D.2    Verdy, E.3    Samama, M.M.4    Elalamy, I.5
  • 16
    • 33744779960 scopus 로고    scopus 로고
    • The status of new anticoagulants
    • Bates SM, Weitz JI. The status of new anticoagulants. Br. J. Haematol. 134(1), 3-19 (2006).
    • (2006) Br. J. Haematol , vol.134 , Issue.1 , pp. 3-19
    • Bates, S.M.1    Weitz, J.I.2
  • 17
    • 22144465855 scopus 로고    scopus 로고
    • Comparison of two low-molecular weight heparins (LMV/H), tinzaparin and bemiparin, during hemodialysis
    • Christidou FN, Frangia TK, Bamichas GI et al. Comparison of two low-molecular weight heparins (LMV/H), tinzaparin and bemiparin, during hemodialysis. Int. J. Clin. Pharmacol. Ther. 43(7), 335-338 (2005).
    • (2005) Int. J. Clin. Pharmacol. Ther , vol.43 , Issue.7 , pp. 335-338
    • Christidou, F.N.1    Frangia, T.K.2    Bamichas, G.I.3
  • 18
    • 55249119666 scopus 로고    scopus 로고
    • Borrell M, Antonijoan RM, Ortiz R et al. Pharmacokinetic profile of two LMWH: bemiparin 3500 IU and enoxaparin 4000 IU after sc administration in healthy volunteers (18th Congress of the International Society of Thrombosis and Haemostasis. Paris, France, 2001). Thromb. Haemost. 86(Suppl.), CD3578 (2001).
    • Borrell M, Antonijoan RM, Ortiz R et al. Pharmacokinetic profile of two LMWH: bemiparin 3500 IU and enoxaparin 4000 IU after sc administration in healthy volunteers (18th Congress of the International Society of Thrombosis and Haemostasis. Paris, France, 2001). Thromb. Haemost. 86(Suppl.), CD3578 (2001).
  • 19
    • 0029040795 scopus 로고
    • The role of tissue factor pathway inhibitor in the mediation of the antithrombotic actions of heparin and low-molecular-weight heparin
    • Hoppensteadt DA, Jeske W, Fareed J, Bermes EW Jr. The role of tissue factor pathway inhibitor in the mediation of the antithrombotic actions of heparin and low-molecular-weight heparin. Blood Coagul. Fibrinolysis. 6(Suppl. 1), S57-S64 (1995).
    • (1995) Blood Coagul. Fibrinolysis , vol.6 , Issue.SUPPL. 1
    • Hoppensteadt, D.A.1    Jeske, W.2    Fareed, J.3    Bermes Jr., E.W.4
  • 20
    • 0028947545 scopus 로고
    • Kinetic behaviour of the TFPI and anti-FXa effects, after the injection of a LMWH(RO- 11) in healthy subjects
    • Falkon L, Garí M, Sáenz-Campos D, Antonijoan R, Barbanoj M, Fontcuberta J. Kinetic behaviour of the TFPI and anti-FXa effects, after the injection of a LMWH(RO- 11) in healthy subjects. Thromb. Haemost. 73(4), 728-729 (1995).
    • (1995) Thromb. Haemost , vol.73 , Issue.4 , pp. 728-729
    • Falkon, L.1    Garí, M.2    Sáenz-Campos, D.3    Antonijoan, R.4    Barbanoj, M.5    Fontcuberta, J.6
  • 21
    • 0031977005 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, Bemiparin, at therapeutic sc doses
    • Falkon L, Garf M, Barbanoj M, Amiral J, Fontcuberta J. Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, Bemiparin, at therapeutic sc doses. Blood Coagul. Fibrinolysis 9(2), 137-141 (1998).
    • (1998) Blood Coagul. Fibrinolysis , vol.9 , Issue.2 , pp. 137-141
    • Falkon, L.1    Garf, M.2    Barbanoj, M.3    Amiral, J.4    Fontcuberta, J.5
  • 22
    • 0034106458 scopus 로고    scopus 로고
    • The Bemiparin Assessment group. A comparative, double-blind, randomized trial of a new second generation LMWH (Bemiparin) and UFH in the prevention of post-operative venous thromboembolism
    • Kakkar W, Howes J, Sharma V, Kadziola Z; The Bemiparin Assessment group. A comparative, double-blind, randomized trial of a new second generation LMWH (Bemiparin) and UFH in the prevention of post-operative venous thromboembolism. Thrumb. Haemost. 83, 523-529 (2000).
    • (2000) Thrumb. Haemost , vol.83 , pp. 523-529
    • Kakkar, W.1    Howes, J.2    Sharma, V.3    Kadziola, Z.4
  • 23
    • 0141823421 scopus 로고    scopus 로고
    • Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: A randomized, double-blind clinical trial
    • Navarro-Quilis A, Castellet E, Rocha E et al. Efficacy and safety of bemiparin compared with enoxaparin in the prevention of venous thromboembolism after total knee arthroplasty: a randomized, double-blind clinical trial. J. Thromb. Haemost. 1(3), 425-432 (2003).
    • (2003) J. Thromb. Haemost , vol.1 , Issue.3 , pp. 425-432
    • Navarro-Quilis, A.1    Castellet, E.2    Rocha, E.3
  • 24
    • 4644307098 scopus 로고    scopus 로고
    • Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous; thromboembolism in total knee replacement surgery
    • Honorato J, Gómez-Outes A, Navarro-Quilis X-Martínez-González J, Rocha E, Planès A. Pharmacoeconomic analysis of bemiparin and enoxaparin as prophylaxis for venous; thromboembolism in total knee replacement surgery. Pharmacoeconomics 22(13), 885-894 (2004).
    • (2004) Pharmacoeconomics , vol.22 , Issue.13 , pp. 885-894
    • Honorato, J.1    Gómez-Outes, A.2    Navarro-Quilis X-Martínez-González, J.3    Rocha, E.4    Planès, A.5
  • 25
    • 34548166531 scopus 로고    scopus 로고
    • A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery
    • Abad JI, Gómez-Outes A, Martínez-González J et al. A prospective observational study on the effectiveness and safety of bemiparin, first dose administered 6 h after knee or hip replacement surgery. Arch. Orthop. Trauma Surg. 127(8), 665-670 (2007).
    • (2007) Arch. Orthop. Trauma Surg , vol.127 , Issue.8 , pp. 665-670
    • Abad, J.I.1    Gómez-Outes, A.2    Martínez-González, J.3
  • 26
    • 37549060400 scopus 로고    scopus 로고
    • Evaluation of the effectiveness and safety of bemiparin in a large population of orthopedic patients in a normal chnical practice
    • Otero-Fernández R, Gómez-Outes A, Martínez-González J et al. Evaluation of the effectiveness and safety of bemiparin in a large population of orthopedic patients in a normal chnical practice. Clin. Appl. Thromb. Hemost. 14(1), 75-83 (2008).
    • (2008) Clin. Appl. Thromb. Hemost , vol.14 , Issue.1 , pp. 75-83
    • Otero-Fernández, R.1    Gómez-Outes, A.2    Martínez-González, J.3
  • 27
    • 34247367703 scopus 로고    scopus 로고
    • Balibrea JL, Altimiras J, Larruzea I et al. Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice. Int J. Surg. 5(2), 114-119 (2007).
    • Balibrea JL, Altimiras J, Larruzea I et al. Optimal dosing of bemiparin as prophylaxis against venous thromboembolism in surgery for cancer: an audit of practice. Int J. Surg. 5(2), 114-119 (2007).
  • 28
    • 33847027686 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy
    • Constans M, Santamaria. A, Mateo J, Pujol N, Souto JC, Fontcuberta J. Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int. J. Clin. Pract. 61(2), 212-217 (2007).
    • (2007) Int. J. Clin. Pract , vol.61 , Issue.2 , pp. 212-217
    • Constans, M.1    Santamaria, A.2    Mateo, J.3    Pujol, N.4    Souto, J.C.5    Fontcuberta, J.6
  • 29
    • 3042639769 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: Assessment of a standardized periprocedural anticoagulation regimen
    • Douketis JD, Johnson JA, Turpie AG. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Arrh. Intern. Med. 164(12), 1319-1326 (2004).
    • (2004) Arrh. Intern. Med , vol.164 , Issue.12 , pp. 1319-1326
    • Douketis, J.D.1    Johnson, J.A.2    Turpie, A.G.3
  • 30
    • 24744436630 scopus 로고    scopus 로고
    • Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation
    • Spyropoulos AC, Turpie AG. Perioperative bridging interruption with heparin for the patient receiving long-term anticoagulation. Curr. Opin. Pulm. Med. 11 (5), 373-379 (2005).
    • (2005) Curr. Opin. Pulm. Med , vol.11 , Issue.5 , pp. 373-379
    • Spyropoulos, A.C.1    Turpie, A.G.2
  • 31
    • 22544463642 scopus 로고    scopus 로고
    • Utilisation and safety of bemiparin, a low-molecular-weight heparin, in medical patients: A prospective, uncontrolled cohort study
    • Miras-Parra F, Navascués-Martínez E, Gómez-Outes A et al. Utilisation and safety of bemiparin, a low-molecular-weight heparin, in medical patients: a prospective, uncontrolled cohort study. Clin. Drug Investig. 25(7), 463-472 (2005).
    • (2005) Clin. Drug Investig , vol.25 , Issue.7 , pp. 463-472
    • Miras-Parra, F.1    Navascués-Martínez, E.2    Gómez-Outes, A.3
  • 32
    • 33947700479 scopus 로고    scopus 로고
    • Safety and effectiveness of bemiparin in the prevention of venous thromboembolic disease in nursing home patients
    • Pritto Seva AJ. Safety and effectiveness of bemiparin in the prevention of venous thromboembolic disease in nursing home patients. Rev. Esp. Geriatr. Gerontol. 42, 20-26 (2007).
    • (2007) Rev. Esp. Geriatr. Gerontol , vol.42 , pp. 20-26
    • Pritto Seva, A.J.1
  • 33
    • 55249088881 scopus 로고    scopus 로고
    • Rodríguez-Mañas L, Gómez-Huelgas R, Monteagudo G, Maeso R, Gómez-Outes A, Martínez-González J. Bemiparin thromboprophylaxis in elderly medical patients: the ANCIANOS study. J. Thromb. Haemost. 5(Suppl. 2), P-T-671 (2007).
    • Rodríguez-Mañas L, Gómez-Huelgas R, Monteagudo G, Maeso R, Gómez-Outes A, Martínez-González J. Bemiparin thromboprophylaxis in elderly medical patients: the "ANCIANOS" study. J. Thromb. Haemost. 5(Suppl. 2), P-T-671 (2007).
  • 34
    • 0037393819 scopus 로고    scopus 로고
    • Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis
    • Kakkar W, Gebska M, Kadziola Z et al. Low-molecular-weight heparin in the acute and long-term treatment of deep vein thrombosis. Thromb. Haemost. 89(4), 674-680 (2003).
    • (2003) Thromb. Haemost , vol.89 , Issue.4 , pp. 674-680
    • Kakkar, W.1    Gebska, M.2    Kadziola, Z.3
  • 35
    • 32044448965 scopus 로고    scopus 로고
    • Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis
    • Gómez-Outes A. Rocha E, Martínez-González J, Kakkar VV. Cost effectiveness of bemiparin sodium versus unfractionated heparin and oral anticoagulants in the acute and long-term treatment of deep vein thrombosis. Pharmacoeconomics 24(1), 81-92 (2006).
    • (2006) Pharmacoeconomics , vol.24 , Issue.1 , pp. 81-92
    • Gómez-Outes, A.1    Rocha, E.2    Martínez-González, J.3    Kakkar, V.V.4
  • 36
    • 33646229797 scopus 로고    scopus 로고
    • Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: The ESFERA Study
    • Santamaría A, Juárez S, Reche A et. al. Low-molecular-weight heparin, bemiparin, in the outpatient treatment and secondary prophylaxis of venous thromboembolism in standard clinical practice: the ESFERA Study. Int. J. Clin. Pract. 60(5), 518-525 (2006).
    • (2006) Int. J. Clin. Pract , vol.60 , Issue.5 , pp. 518-525
    • Santamaría, A.1    Juárez, S.2    Reche, A.3    et., al.4
  • 37
    • 33750049003 scopus 로고    scopus 로고
    • FLEBUS Investigators. Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: The FLEBUS study
    • Lecumberri R, Rosario E, Pacho J, Rocha E; FLEBUS Investigators. Fixed-dose low-molecular-weight heparin, bemiparin, in the long-term treatment of venous thromboembolism in patients with transient risk factors in standard clinical practice: the FLEBUS study. J. Thromb. Haemost. 4(11), 2504-2508 (2006).
    • (2006) J. Thromb. Haemost , vol.4 , Issue.11 , pp. 2504-2508
    • Lecumberri, R.1    Rosario, E.2    Pacho, J.3    Rocha, E.4
  • 39
    • 28844462321 scopus 로고    scopus 로고
    • Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients
    • Siragusa S, Arcara C, Malato A et al. Home therapy for deep vein thrombosis and pulmonary embolism in cancer patients. Ann. Oncol. 16(Suppl. 4), iv136-iv139 (2005).
    • (2005) Ann. Oncol , vol.16 , Issue.SUPPL. 4
    • Siragusa, S.1    Arcara, C.2    Malato, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.