Tyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 9, 2010, Pages 5368-5373

  Zheng, Zong Ping ^a   Cheng, Ka Wing ^a   Zhu, Qin ^a   Wang, Xia Chang ^b   Lin, Zhi Xiu ^c   Wang, Mingfu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Hainan Provincial Institute for Drug Control   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Morus nigra; Phenolic compounds; Tyrosinase inhibition

Indexed keywords

ENZYME INHIBITOR; MONOPHENOL MONOOXYGENASE; PLANT EXTRACT;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; MULBERRY; PLANT ROOT; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; MONOPHENOL MONOOXYGENASE; MORUS; PLANT EXTRACTS; PLANT ROOTS; STRUCTURE-ACTIVITY RELATIONSHIP;

MORUS (ANGIOSPERM); MORUS ALBA; MORUS NIGRA;

EID: 77952224236     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf1003607     Document Type: Article

References (24)

1. Mayer, A. M. Polyphenol oxidases in plants: recent progress Phytochemistry 1987, 26, 11-20
2. Slominski, A.; Tobin, D. J.; Shibahara, S.; Wortsman, J. Melanin pigmentation in mammalian skin and its hormonal regulation Phys. Rev. 2004, 84, 1155-1228
3. Rigal, D.; Cerny, M.; Richard-Forget, F.; Varoquaux, P. Polyphenoloxidase by a Carica papaya latex preparation Int. J. Food Sci. Technol. 2001, 36, 677-684
4. Son, S. M.; Moon, K. D.; Lee, C. Y. Inhibitory effects of various anti-browning agents on apple slices Food Chem. 2001, 73, 23-30
5. Shimizu, K.; Kondo, R.; Sakai, K. Inhibition of tyrosinase by flavonoids, stilbenes and related 4-substituted resorcinols: structureactivity investgations Planta Med. 2000, 66, 11-15
6. Kim, H. J.; Seo, S. H.; Lee, B. G.; Lee, Y. S. Identification of tyrosinase inhibitors from Glycyrrhiza uralensis Planta Med. 2005, 71, 785-787
7. Funyama, M.; Arakawa, H.; Yamamoto, R.; Nishino, T.; Shin, T.; Murao, S. Effects of α and β arbutin on the activity of tyrosinase from mushroom and mouse melanoma Biosci. Biotechnol. Biochem. 1995, 59, 143-144
8. Blaut, M.; Braune, A.; Wunderlich, S.; Sauer, P.; Schneider, H.; Glatt, H. Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria Food Chem. Toxicol. 2006, 44, 1940-1947
9. Williams, G. M.; Iatropoulos, M. J.; Jeffrey, A. M.; Duan, J. D. Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis Food Chem. Toxicol. 2007, 45, 1620-1625
10. Parvez, S.; Kang, M.; Chung, H. S.; Cheo, C.; Hong, M. C.; Shin, M. K.; Bae, H. Survery and mechanism of skin depigmenting and lightening agents Phytother. Res. 2006, 20, 921-934
11. Nakagawa, M.; Kawai, K.; Kawai, K. Contact allergy to kojic acid in skin care products Contact Dermatitis 1995, 32, 9-13
12. Nerya, O.; Vaya, J.; Musa, R.; Izrael, S.; Ben-Arie, R.; Tamir, S. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots J. Agric. Food Chem. 2003, 51, 1201-1207
13. Shanker, K.; Fatima, A.; Negi, A. S.; Gupta, V. K.; Darokar, M. P.; Gupta, M. M.; Khanuja, S. P. S. RP-HPLC method for the quantitation of glabridin in Yashti-madhu (Glycyrrhiza glabra) Chromatographia 2007, 65, 771-774
14. Hoang, D. M.; Ngoc, T. M.; Dat, N. T.; Ha, D. T.; Kim, Y. H.; Luong, H. V.; Ahn, J. S.; Bae, K. H. Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis Bioorg. Med. Chem. Lett. 2009, 19, 6759-6761
15. Zhang, M.; Chen, M.; Zhang, H. Q.; Sun, S.; Xia, B.; Wu, F. H. In vivo hypoglycemic effects of phenolics from the root bark of Morus alba Fitoterapia 2009, 80, 475-477
16. Liu, L. K.; Chou, F. P.; Chen, Y. C.; Chyau, C. C.; Ho, H. H.; Wang, C. J. Effects of mulberry (Morus alba L.) extracts on lipid homeostasis in vitro and in vivo J. Agric. Food Chem. 2009, 57, 7605-7611
17. Zhang, Q. J.; Ni, G.; Wang, Y. H.; Chen, R. Y.; Yu, D. Q. Three new Diels-Alder type adducts from the stem bark of Morus cathayana J. Asian Nat. Prod. Res. 2009, 11, 267-273
18. Piao, S. J.; Qiu, F.; Chen, L. X.; Pan, Y.; Dou, D. Q. New stilbene, benzofuran, and coumarin glycosides from Morus alba Helv. Chim. Acta 2009, 92, 579-587
19. Pawlowska, A. M.; Oleszek, W.; Braca, A. Quali-quantitative analyses of flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits J. Agric. Food Chem. 2008, 56, 3377-3380
20. Ercisli, S.; Orhan, E. Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits Food Chem. 2007, 103, 1380-1384
21. Wang, L.; Wang, H. Q.; Chen, R. Y. Studies on chemical constituents from bark of Morus nigra Zhongguo Zhongyao Zazhi 2007, 32, 2497-2499
22. Zheng, Z. P.; Chen, S.; Wang, S.; Wang, X. C.; Cheng, K. W.; Wu, J. J.; Yang, D. J.; Wang, M. Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus J. Agric. Food Chem. 2009, 57, 6649-6655
23. Zheng, Z. P.; Cheng, K. W.; To, J. T. K.; Li, H.; Wang, M. Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as anti-browning agent Mol. Nutr. Food Res. 2008, 12, 1530-1538
24. Zhang, X.; Hu, X.; Hou, A.; Wang, H. Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis Biol. Pharm. Bull. 2009, 32, 86-90